缬沙坦对高脂血症动脉粥样硬化模型大鼠炎性因子的影响(1)
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[摘要] 目的 观察缬沙坦对炎性因子水平的影响，探讨其对高脂血症模型大鼠动脉粥样硬化的影响。 方法 选取30只雄性健康Wistar大鼠，适应性喂养1周后，随机分为3组：正常对照组10只，高脂模型组10只和缬沙坦干预组10只。通过建立高脂血症动脉粥样硬化大鼠模型，动态、系统地监测TNF-α、IL-6和IL-8的水平。 结果 高脂模型组血清TNF-α、IL-6、IL-8水平均较正常对照组升高，且比较差异具有统计学意义(P < 0.05)。应用缬沙坦治疗10周后，缬沙坦干预组IL-6的水平较高脂模型组降低，比较差异有统计学意义(P < 0.05)；TNF-α和IL-8水平较高脂模型组降低，但比较差异无统计学意义(P > 0.05)。 结论 缬沙坦能够有效地降压的同时，能减少部分炎性因子释放，发挥其抗动脉粥样硬化的作用。
[关键词] 高脂血症；动脉粥样硬化；缬沙坦；炎性因子
[中图分类号] R965.1 [文献标识码] A [文章编号] 1674-4721(2012)02(b)-0015-02
Effects of valsartan on inflammatory factor in rats hyperlipidemia athrosclerosis model
REN Xiaobo
Department of Internal Medicine, the 2nd People′s Hospital of Changsha County in Hunan Province, Changsha 410100, China
[Abstract] Objective To study the effects of valsartan on athrosclerosis in rats hyperlipidemia mode, and explore the influence of the level of inflammatory factor. Methods Thirty male health Wistar rats were selected, and feeded adaptability, and randomly divided into three groups: normal control group, high fat model group, and losartan intervention group after a week. The levels of serum lipids TNF-α, IL-6, IL-8 of the hyperlipidemia and atherosclerosis model rats were monitored dynamically and systematically before and after the intervention of valsartan. Results Serum TNF-α, IL-6 and IL-8 in hyperlipaemia group was significantly higher than that of normal group (P < 0.05). The expression of IL-6 in valsartan group were lower than that of hyperlipaemia group, there was significant difference among valsartan group and hyperlipaemia group (P < 0.05). The expression of TNF-α and IL-8 in valsartan group were lower than that of hyperlipaemia group, but there was no significant difference (P > 0.05). Conclusion While valsartan can effectively lower blood pressure, and can play the anti-atherosclerotic effect by reducing some inflammatory cytokine.
[Key words] Hyperlipidemia; Athrosclerosis; Valsartan; Inflammation factors
动脉粥样硬化(atherosclerosis，AS)以前被认为是一种脂质沉积性疾病，近年来大量研究证实，动脉粥样硬化是炎症参与的慢性疾病[1]。肿瘤坏死因子α(TNF-α)，白介素-6(IL-6)以及白介素-8(IL-8)是重要的促炎症因子，参与了动脉粥样硬化的形成及发展过程[2]。研究发现血管紧张素Ⅱ受体拮抗剂除降压作用外，还具有抗动脉粥样硬化作用[3]，笔者通过建立高脂血症动脉粥样硬化大鼠模型，动态、系统地监测了缬沙坦干预后炎性因子水平的变化，观察缬沙坦的抗动脉粥样硬化效果。现报道如下：
1 材料与方法
1.1 实验材料
于2010年6～10月选用30只雄性健康Wistar大鼠进行实验，所有大鼠体重100～120 g ......
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