鸦胆子油乳联合顺铂胸腔内灌注治疗肺癌所致恶性胸腔积液的疗效观察(1)
 |
| 第1页 |
参见附件(1446KB，2页)。
[摘要] 目的 观察鸦胆子油乳联合顺铂胸腔内灌注治疗肺癌所致恶性胸腔积液的疗效。方法 将64例确诊为肺癌所致恶性胸腔积液患者随机分为治疗组和对照组，每组32例，留置导管排尽胸水后，治疗组给予顺铂40 mg/m2，鸦胆子油乳100 mL胸腔灌注。对照组仅给予顺铂40 mg/m2胸腔灌注，5~7 d灌注1次，共4次。结束后观察临床疗效、生活质量及毒副作用。结果 治疗组有效率、生活质量改善率高于对照组，而毒副反应低于对照组。两组比较差异均有统计学意义(P < 0.05)。 结论 鸦胆子油乳联合顺铂胸腔灌注治疗肺癌所致恶性胸腔积液疗效优于单用顺铂，具有临床应用价值。
[关键词] 鸦胆子油乳；肺癌；恶性胸腔积液；顺铂
[中图分类号] R734.2 [文献标识码] A [文章编号] 1674-4721(2012)03(a)-0047-02
Clinical observation of Brucea Javanica oil Emulsion and Cisplatinum on treating lung cancer m alignant pleural effussion
LIU Bao ZHANG Limin
1th Department of Oncology, The Affilicited Tumour Hospital of Harbin Medical University in Heilongjiang Province, Harber 150040, China
[Abstract] Objective To evaluate the curative effects on lung cancer m alignant pleural effusion treated with brucea javanica oil emulsion and cisplatinum. Methods Sixty four cases of patients suffering from lung cancer m alignant pleural effusion were randomized into two groups: 32 patients in the treatment group were treated with brucea javanica oil emulsion(100 mL) and cisplatinum(40 mg/m2) by intrathoracic injection after thoracocentesis. While in control group 32 patients were treated with cisplatinum(40 mg/m2) by intrathoracic injection. Every 5 to 7 days once and total of four times. The target of observation were clinical efficancy, quality of life and side-effects. Results The effectiverate and improvement rate of life quality in treatment group were higher than the control group, and the side-effect of the therapy was lower. The difference was significant (P < 0.05). Conclusion To control the lung cancer m alignant pleural effusion, the curative effects of brucea javanica oil emulsion and cisplatinum together by intrathoracic injection after thoracocentesis is superior to single cisplatinum, and this treatment had the value of clinical application.
[Key words] Brucea javanica oil emulsion；Lung cancer；Pleural effusion；Cisplatinum
目前数据显示肺癌已成为危害我国居民健康的第一位恶性肿瘤，而恶性胸腔积液是晚期肺癌的常见并发症之一，其可由于病情发展在短期内迅速增加压迫肺组织，导致肺不张、纵隔偏移，患者可因胸腔积液量不同出现不同程度呼吸困难等症状，患者生活质量受到不同程度影响，甚至可引起患者死亡。而鸦胆子油乳联合顺铂胸腔灌注，可有效控制胸腔积液，改善患者生活质量，现总结2009年12月~2010年11月本科采用鸦胆子油乳联合顺铂胸腔灌注治疗肺癌所致恶性胸腔积液患者64例 ......
您现在查看是摘要介绍页，详见PDF附件(1446KB，2页)。