普罗帕酮与胺碘酮治疗阵发性室上性心动过速的临床对比研究(1)
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[摘要] 目的 比较静脉注射普罗帕酮与胺碘酮治疗阵发性室上性心动过速(PSVT)的临床疗效及安全性。 方法 将本院2009年1月～2012年1月急诊及住院的PSVT患者86例，随机分为普罗帕酮组45例和胺碘酮组41例，分别给予普罗帕酮、胺碘酮静脉注射治疗，比较两组用药前后转复时间、转复有效率及不良反应率。 结果 普罗帕酮组转复时间为(8.14±1.80) min，胺碘酮组为(19.31±2.95) min，两组比较差异有统计学意义(t = 21.58，P < 0.05)；两组转复率分别为84.44%(38/45)、85.37%(35/41)，差异无统计学意义(χ2=0.12，P > 0.05)；两组不良反应发生率差异无统计学意义(22.22% vs 21.95%，χ2=0.01，P > 0.05)。 结论 静脉注射普罗帕酮与胺碘酮治疗阵发性室上性心动过速安全、有效，均可作为治疗PSVT的一线药物。
[关键词] 普罗帕酮；胺碘酮；阵发性室上性心动过速；对比研究
[中图分类号] R541.7+1 [文献标识码] A [文章编号] 1674-4721(2012)03(c)-0067-02
Clinical comparative study of Propafenone and Amiodarone treatment on paroxysmal supraventricular tachycardia
LI Ning XIAN Xinping
Department of Cardiovascular Internal Medicine, Traditional Chinese Hospital of Dujiangyan City in Sichuan Province, Dujiangyan 611830, China
[Abstract] Objective To explore the effect and safety of intravenous Propafenone and Amiodarone treatment on paroxysmal supraventricular tachycardia (PSVT). Methods Eighty-six patients of PSVT who were admitted our hospital from January 2009 to January 2012 were randomly divided into two groups, intravenous Propafenone group (n = 45) and intravenous Amiodarone group(n = 41). Comparition of the termination rate and adverse events rate were observed between the two groups. Results The time of heart beat recovery in Propafenone group were (8.14±1.80) min and Amiodarone group were (19.31±2.95) min, there had difference of statistical significance between the two groups (t = 21.58, P < 0.05). The termination rate of PSVT was 84.44% (38/45)in Propafenone group and 85.37% (35/41) in Amiodarone group, showed no significant difference (χ2=0.12, P > 0.05). The incidence rates of side effect were respectively without significant difference (22.22% vs 21.95%, χ2=0.01, P > 0.05). Conclusion Intravenous Propafenone and Amiodarone treatment on clonic paroxysmal supraventricular tachycardia is safe, effective and can be used as a drug treatment PSVT line.
[Key words] Propafenone; Amiodarone; Tachycardia; Supraventricular; Clinical comparison ......
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