厄贝沙坦联合辛伐他汀对高血压微量清蛋白尿的影响(1)
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[摘要] 目的 观察厄贝沙坦联合辛伐他汀对高血压患者微量清蛋白尿的影响。 方法 将72例高血压伴微量清蛋白尿患者随机分为观察组和对照组,每组各36例。对照组给予厄贝沙坦进行治疗,观察组在此基础上加用辛伐他汀,疗程均为24周。分别于治疗前后测定两组患者的血压、24 h尿微量清蛋白量(24h U-Alb)、血清肌酐(SCr)、尿素氮(BUN)等指标。 结果 治疗结束后,两组患者血压均显著下降(P < 0.05),观察组24h U-Alb、BUN、SCr等指标值均较治疗前及对照组同期显著降低(P < 0.05)。 结论 厄贝沙坦联合辛伐他汀对高血压伴微量清蛋白尿患者的临床疗效显著,值得推广使用。
[关键词] 厄贝沙坦;辛伐他汀;高血压;微量清蛋白尿
[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-4721(2012)07(a)-0086-02
Effects of irbesartan and simvastatin on hypretension microalbuminuria
Aizemujiang·tuersun
The People's Hospital of Shache County in Kashi City, Xinjing Uygur Autonomous Region, Shache 844700, China
[Abstract] Objective To observe the effects of irbesartan and simvastatin in patients with hypretension and microalbuminuria. Methods Seventy-two patients with hypertension and microalbuminuria were randomly divided into observation group (n = 36) and control group (n = 36). The control group was treated with irbesartan, and on the basis of this, the observation group was treated with simvastatin for 24 weeks. The changes of blood pressure, 24h U-Alb, SCr and BUN were observed before and after treatment. Results The antihypertensive efficacy were similar in patients of the two groups, but the levels of 24h U-Alb, SCr and BUN in the observation were significantly lower than those before treatment and in the control group (P < 0.05). Conclusion The combination of irbesartan and simvastatin has definite clinical effect in treating patients with essential hypretension and microalbuminuria.
[Key words] Irbesartan; Simvastati; Hypretension; Microalbuminuria
原发性高血压是常见的心血管疾病,肾脏受损是其最常见并发症之一,高血压伴早期肾脏损害患者除具有体循环动脉血压值持续升高的临床表现外,尿中可检出微量清蛋白[1]。因此,对高血压伴早期肾损害患者,除考虑平稳降低患者血压值外,尚需针对肾损害情况采取积极有效的治疗措施 ......
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