缬沙坦联合氢氯噻嗪治疗高血压临床疗效分析(1)
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[摘要] 目的 比较缬沙坦联合氢氯噻嗪与单独应用缬沙坦治疗原发性高血压的临床疗效，从而指导临床治疗。 方法 将本院收治的86例原发性高血压患者随机分为实验组和对照组，实验组患者与对照组患者均给予80 mg/d剂量的缬沙坦治疗，实验组在此基础上给予12.5 mg/次、2次/d的氢氯噻嗪，治疗8周后，比较两组患者的临床治疗有效率及不良反应的发生率。 结果 实验组治疗后收缩压、舒张压均显著低于对照组(P < 0.05)，实验组患者治疗后总有效率为90.7%，不良反应发生率为4.7%；对照组患者治疗后总有效率为79.1%，不良反应的发生率为4.7%；实验组总有效率显著高于对照组(P < 0.05)，两组患者的脉压、不良反应发生率差异无统计学意义(P > 0.05)。 结论 缬沙坦联合氢氯噻嗪治疗原发性高血压与单独应用缬沙坦相比，能够显著提高治疗的有效率，且不良反应轻微，安全性较好。
[关键词] 缬沙坦；氢氯噻嗪；高血压；临床疗效
[中图分类号] R972+.4 [文献标识码] A [文章编号] 1674-4721(2012)07(a)-0101-02
Clinical efficacy analysis of valsartan combined with hydrochlorothiazide in treatment of hypertension
CAO Kai
Internal Medicine, Midi Hospital of Panzhihua City in Sichuan Province, Panzhihua 617063, China
[Abstract] Objective To compare the clinical efficacy between valsartan combined hydrochlorothiazide and valsartan alone in treating essential hypertension, to guide the clinical treatment. Methods Eighty-six patients with essential hypertension in our hospital were randomly divided into experimental and control group. The experimental group and control group patients were given 80 mg/d dose of valsartan, and the experimental group was given hydrochlorothiazide, 12.5 mg one time, 2 times a day. After 8 weeks of treatment, the clinical effective rate and the incidence of adverse reactions were compared. Results After treatment, SBP and DBP of the experimental group was significantly lower than that of control group (P < 0.05), the clinical total effective rate and the incidence of adverse reactions of the experimental group were 90.7% and 4.7%, while the control group were 79.1% and 4.7%. The clinical total effective rate of experimental group was significantly higher than that of control group (P < 0 ......
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