系统性红斑狼疮合并血小板减少危险因素Logistic回归分析(1)
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[摘要] 目的 分析系统性红斑狼疮(SLE)合并血小板减少危险因素。 方法 采用回顾性研究方法，对85例系统性红斑狼疮合并血小板减少相关因素进行多因素非条件Logistic回归分析，并血小板减少的住院患者进行回顾性分析，以同期住院的无血小板减少的SLE患者作为对照，探讨血小板减少的危险因素。 结果 85例SLE住院患者，出现血小板减少者有24例，占28.24%，其中14例出现轻度血小板减少，6例出现中度血小板减少，4例为重度血小板减少。SLE患者合并浆膜炎、血液系统受累、ACA阳性及脾大者易出现血小板减少。血小板减少组肾脏损害的发生率高于血小板正常患者，但蝶形红斑的发生率低于后者，差异均有统计学意义(P < 0.05)。 结论 SLE患者合并浆膜炎、血液系统受累、ACA阳性及脾大者易出现血小板减少。
[关键词] 系统性红斑狼疮；血小板减少；危险因素；分析
[中图分类号] R593.24+1 [文献标识码] A [文章编号] 1674-4721(2012)07(b)-0039-03
The risk factors Logistic regression analysis of systemic lupus erythematosus combine with thrombocytopenia
ZHONG Ruiqiong LUO Weiyan
Department of Nephrology, Gaozhou People's Hospital in Guangdong Province, Gaozhou 525200, China
[Abstract] Objective To analyze the risk factors of systemic lupus erythematosus combine with thrombocytopenia. Methods The associated factors of 85 cases of systemic lupus erythematosus combined with thrombocytopenia were retrospectively studied by non-conditional Logistic regression analysis. Patients with thrombocytopenia were analyzed retrospectively and compared with SLE patients who had not thrombocytopenia in the same period, risk factors for thrombocytopenia were analyzed. Results In 85 cases of hospitalized patients with SLE, there were 24 cases of thrombocytopenia, accounted for 28.24%, including 14 cases of mild thrombocytopenia, 6 patients of moderate thrombocytopenia, 4 cases of severe thrombocytopenia. SLE patients who supervened with serositis, hematologic involvement, ACA positive and splenomegaly were likely to have thrombocytopenia. Thrombocytopenia kidney damage rate was higher than that of patients with normal platelet, but butterfly erythema occur rate was lower than that of the latter, the difference was statistically significant(P < 0 ......
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