激光术联合聚甲酚磺醛溶液治疗中重度宫颈糜烂疗效观察
[摘要] 目的 探讨激光术联合应用聚甲酚磺醛溶液治疗中重度宫颈糜烂的临床疗效。 方法 选取中重度宫颈糜烂患者100例，随机分为两组：激光联合聚甲酚磺醛溶液组(治疗组)50例，激光组(对照组)50例，观察两组的治疗效果与不良反应。 结果 治疗组的宫颈创面愈合情况以及术后阴道流液、流血、感染等不良反应方面明显优于对照组，两组差异有统计学意义(P < 0.05)。 结论 激光术联合应用聚甲酚磺醛溶液治疗中重度宫颈糜烂治愈率高，疗效显著，并能有效控制术后不良反应，值得临床推广。
[关键词] 宫颈糜烂；聚甲酚磺醛溶液；宫颈激光术；疗效
[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721(2012)07(c)-0069-02
The effects observation of laser surgery combined with policresulen solution in treatment of moderate and severe cervical erosion
, 百拇医药
ZHENG Huipin
Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Sihui City in Guangdong Province, Sihui 526200, China
[Abstract] Objective To explore the effects of laser surgery combined with policresulen solution in treatment of moderate and severe cervical erosion. Methods One hundred cases of moderate and severe cervical erosion were randomly divided into two groups: laser surgery combined with policresulen solution (treatment group) with 50 cases, and the laser group (control group) with 50 cases, The therapeutic effects and adverse reactions in two groups were observed. Results The adverse reactions of the cervical wound healing, postoperative vaginal fluid, bleeding and infection in the treatment group were better than those in the control group. The differences were statistically significant (P < 0.05). Conclusion The cure rate of laser surgery combined with policresulen solution in treatment of moderate and severe cervical erosion is high, with a significant effect. It can also effectively control postoperative adverse reactions, so it is worthy of being popularized.
, http://www.100md.com
[Key words] Cervical erosion; Policresulen solution; Cervical laser surgery; Effects
宫颈糜烂是慢性宫颈炎最常见的一种病理改变，是已婚、育龄妇女的常见病、多发病，也是宫颈癌发病的高危因素之一。目前治疗宫颈糜烂的方法有很多，药物治疗仅适合糜烂面积较小和炎症浸润较表浅的患者[1]。对于中重度宫颈糜烂，物理治疗仍是最常用的有效治疗方法。但术后不良反应也相应出现，如阴道排液、异味、阴道出血，甚至合并感染、宫颈粘连等。本院采用宫颈激光术联合应用聚甲酚磺醛溶液能提高治愈率，缩短治愈时间，有效避免其并发症的发生，降低复发率。现将近一年多来开展激光术联合应用聚甲酚磺醛溶液治疗中重度宫颈糜烂的临床效果观察情况报道如下：
1 资料与方法
1.1 一般资料
, http://www.100md.com 2010年6月～2012年2月，本院门诊检查初步诊断为宫颈中重度糜烂患者100例，年龄22～55岁，均为非孕期、哺乳期、已生育妇女。随机分为两组：激光联合聚甲酚磺醛溶液组(治疗组)、激光组(对照组)。术前经盆腔检查及白带常规排除急性生殖道感染、阴道炎，TCT检查排除癌细胞或癌前病变。两组中度宫颈糜烂患者各29例，重度各21例，年龄、病变类型和病变程度等差异无统计学意义(P > 0.05)，具有可比性。
1.2 诊断标准
根据糜烂面积分为3度，Ⅰ度(轻度)：糜烂面少于整个宫颈面积1/3；Ⅱ度(中度)：糜烂面积占整个宫颈面积1/3～2/3；Ⅲ度(重度)：糜烂面积占整个宫颈面积2/3以上[2]。
1.3 治疗方法
治疗时间在月经干净后3～7 d内。对照组：CO2激光治疗仪，治疗时患者取膀胱截石位，常规消毒外阴和阴道，放置窥器后，擦净宫颈及阴道分泌物，再次碘伏消毒宫颈及阴道，选择输出功率为3～5 W，电压为 220 V/50 Hz，治疗范围超过糜烂面3 mm，直至病变组织凝固变焦黄为止。治疗组：用激光治疗后将浸有甲酚磺醛溶液(华北制药股份有限公司生产25 mL/瓶)的棉签插入宫颈管，然后再将浸有聚甲酚磺醛溶液的消毒棉块敷贴于宫颈术后创面，保留15 min后取出棉签及棉块。每周上药2次，共6次。两组患者术后均要保持外阴清洁，禁性生活及盆浴2个月。随访3个月，记录宫颈创面愈合程度及愈合时间、阴道排液及出血时间。, 百拇医药(郑慧频)
[关键词] 宫颈糜烂；聚甲酚磺醛溶液；宫颈激光术；疗效
[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721(2012)07(c)-0069-02
The effects observation of laser surgery combined with policresulen solution in treatment of moderate and severe cervical erosion
, 百拇医药
ZHENG Huipin
Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Sihui City in Guangdong Province, Sihui 526200, China
[Abstract] Objective To explore the effects of laser surgery combined with policresulen solution in treatment of moderate and severe cervical erosion. Methods One hundred cases of moderate and severe cervical erosion were randomly divided into two groups: laser surgery combined with policresulen solution (treatment group) with 50 cases, and the laser group (control group) with 50 cases, The therapeutic effects and adverse reactions in two groups were observed. Results The adverse reactions of the cervical wound healing, postoperative vaginal fluid, bleeding and infection in the treatment group were better than those in the control group. The differences were statistically significant (P < 0.05). Conclusion The cure rate of laser surgery combined with policresulen solution in treatment of moderate and severe cervical erosion is high, with a significant effect. It can also effectively control postoperative adverse reactions, so it is worthy of being popularized.
, http://www.100md.com
[Key words] Cervical erosion; Policresulen solution; Cervical laser surgery; Effects
宫颈糜烂是慢性宫颈炎最常见的一种病理改变，是已婚、育龄妇女的常见病、多发病，也是宫颈癌发病的高危因素之一。目前治疗宫颈糜烂的方法有很多，药物治疗仅适合糜烂面积较小和炎症浸润较表浅的患者[1]。对于中重度宫颈糜烂，物理治疗仍是最常用的有效治疗方法。但术后不良反应也相应出现，如阴道排液、异味、阴道出血，甚至合并感染、宫颈粘连等。本院采用宫颈激光术联合应用聚甲酚磺醛溶液能提高治愈率，缩短治愈时间，有效避免其并发症的发生，降低复发率。现将近一年多来开展激光术联合应用聚甲酚磺醛溶液治疗中重度宫颈糜烂的临床效果观察情况报道如下：
1 资料与方法
1.1 一般资料
, http://www.100md.com 2010年6月～2012年2月，本院门诊检查初步诊断为宫颈中重度糜烂患者100例，年龄22～55岁，均为非孕期、哺乳期、已生育妇女。随机分为两组：激光联合聚甲酚磺醛溶液组(治疗组)、激光组(对照组)。术前经盆腔检查及白带常规排除急性生殖道感染、阴道炎，TCT检查排除癌细胞或癌前病变。两组中度宫颈糜烂患者各29例，重度各21例，年龄、病变类型和病变程度等差异无统计学意义(P > 0.05)，具有可比性。
1.2 诊断标准
根据糜烂面积分为3度，Ⅰ度(轻度)：糜烂面少于整个宫颈面积1/3；Ⅱ度(中度)：糜烂面积占整个宫颈面积1/3～2/3；Ⅲ度(重度)：糜烂面积占整个宫颈面积2/3以上[2]。
1.3 治疗方法
治疗时间在月经干净后3～7 d内。对照组：CO2激光治疗仪，治疗时患者取膀胱截石位，常规消毒外阴和阴道，放置窥器后，擦净宫颈及阴道分泌物，再次碘伏消毒宫颈及阴道，选择输出功率为3～5 W，电压为 220 V/50 Hz，治疗范围超过糜烂面3 mm，直至病变组织凝固变焦黄为止。治疗组：用激光治疗后将浸有甲酚磺醛溶液(华北制药股份有限公司生产25 mL/瓶)的棉签插入宫颈管，然后再将浸有聚甲酚磺醛溶液的消毒棉块敷贴于宫颈术后创面，保留15 min后取出棉签及棉块。每周上药2次，共6次。两组患者术后均要保持外阴清洁，禁性生活及盆浴2个月。随访3个月，记录宫颈创面愈合程度及愈合时间、阴道排液及出血时间。, 百拇医药(郑慧频)