幽门螺杆菌感染和p53表达与胃癌及胃癌前病变关系的临床研究(2)
| 第1页 |
参见附件。
综上所述，Hp感染与GC的发生、发展密切相关，与细胞凋亡调控蛋白p53可能存在相互协同关系。Hp和p53检测对GC早期诊断和治疗具有重要价值。
[参考文献]
[1] Guo M，Bruce AH.Cell proliferation and apoptosis[J].Curr Opin Cell Biol，1999，11(6)：745-752.
[2] Zilfou JT，Lowe SW.Tumor suppressive functions of p53[J].Cold Spring Harb Perspect Biol，2009，1(5)：a001883.
[3] Breen L，Heenan M，Amberger-Murphy V，et al.Investigation of the role of p53 in chemotherapy resistance of lung cancer cell lines[J].Anticancer Res，2007，27(3A)：1361-1364.
[4] Yu J，BaronV，Mercola D，et al.A network of p73，p53 and Egr1 is required for efficient apoptosis in tumor cells[J].Cell Death Differ，2007，14(3)：436-446.
[5] Xia HH，Talley NJ.Apoptosis in gastric epithelium induced by Helicobacter pylori infection：implications in gastric carcinogenesis[J].Am J Gastroenterol，2001，96(1)：16-26.
[6] Saxena A，Shukla SK，Prasad KN，et al.Analysis of p53，K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India[J].Indian J Med Res，2012，136(4)：664-670.
[7] Shiao YH，Rugge M，Correa P，et al.p53 alteration in gastric precancerous lesions[J].Am J Pathol，1994，144(3)：511-517.
[8] Shun CT，Wu MS，Lin JT，et al.Relationship of p53 and c-erbB-2 expression to histopathological features，Helicobacter pylori infection and prognosis in gastric cancer[J].Hepatogastroenterology，1997，44(14)：604-609.
[9] Xu AG，Li SG，Liu JH，et al.Function of apoptosis and expression of the proteins Bcl-2，p53 and C-myc in the development of gastric cancer[J].World J Gastroenterol，2001， 7(3)：403-406.
[10] Wei JX，Noto JM，Zaika E，et al.Sa1896 the human gastric pathogen Helicobacter pylori alters intracellular signaling by inducing truncated forms of p53 tumor suppressor[J].Gastroenterology，2013，144(5)：S-329.
(收稿日期：2013-10-10 本文编辑：李亚聪)
您现在查看是摘要介绍页，详见PDF附件。