普罗布考治疗非增生性糖尿病视网膜病变的效果评价(2)
综上所述，普罗布考的不良反应较少，治疗过程安全，其机制可能与增强糖尿病视网膜病变患者的抗氧化应激状态有关，需进一步进行分子机制研究及临床应用推广。
[参考文献]
[1] Brownlee M.Biochemistry and molecular cell biology of diabetic complications[J].Nature，2001，414(6865)：813-820.
[2] Virag L，Szabó C.The therapeutic potential of poly(ADP-ribose)polymerase inhibitors[J].Pharmacol Rev，2002，54(3)：375-429.
[3] Obrosova IG，Pacher P，Szabo C，et al.Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose)polymerase activation in tissue sites for diabetes complications[J].Diabetes，2005，54(1)：234-242.
[4] Yokoi M，Yamagishi S，Takeuchi M，et al.Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy[J].Br J Ophthalmol，2005，89(6)：673-675.
[5] Du Y，Miller CM，KemTS.Hyperglycemia increases mi-tochondrial superoxide in retina and retinal cells[J].Free RadicBiol Med，2003，35(11)：1491-1499.
[6] Kowaltowski AJ，Castilho RF，Vercesi AE.Mitochondrial permeabilitytransition and oxidative stress[J].FEBS Lett，2001， 495(1/2)：12-15.
[7] Kern TS，Tang J，Mizutani M，et al.Response of capillary cell death to aminoguanidine predicts the development of retinopathy：comparison of diabetes and galactosemia[J].Invest Ophthalmol Vis Sci，2000，41(12)：3972-3978.
[8] Podesta F，Romeo G，Liu WH，et al.Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro[J].Am J Pathol，2000，156(3)：1025-1032.
[9] Mohr S，Tang J，Kern TS，et al.Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients[J].Diabetes，2002，51(4)：1172-1179.
[10] Romeo G，Liu WH，Asnaghi V，et al.Activation of nuclear factor-Kappa B induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes[J].Diabetes，2002，51(7)：2241-2248.
[11] 陈永东，许讯.氧化应激在糖尿病视网膜病变中的作用研究进展[J].中华眼底病杂志，2007，23(4)：298-300.
[12] O′Leary VJ，TillingL，FleetwoodG，et al.The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy[J].Atherosclerosis，1996，119(2)：169-179.
[13] Bamhart RL，Busch SJ，Jackson RL.Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro：probucol degradation Precedes lipoprotein oxidation[J].J Lipid Res，1989，30(11)：1703-1710.
[14] Baumstark MW，Aristegui R，Zoller T，et al.Probucol，incorporated into LDL particles in vivo，inhibits generation of lipid peroxides more effectively than endogenous antioxidants alone[J].Clin Biochem，1992，25(5)：395-397.
[15] Masana L，Bargallo MT，Plana N，et al.Effeetiveness of pro-bucolinreducing plasma low-density lipoprotein cholesterol oxidation in hypercholesterolemia[J].Am J Cardiol，1991，68(9)：863-867.
[16] 刘庆淮，谢平，戈应滨，等.一氧化氮及其合成酶在糖尿病视网膜损伤中的作用[J].中华眼科杂志，2005，41(9)：837-841.
(收稿日期：2014-09-12 本文编辑：李亚聪) (蒋苏平)
[参考文献]
[1] Brownlee M.Biochemistry and molecular cell biology of diabetic complications[J].Nature，2001，414(6865)：813-820.
[2] Virag L，Szabó C.The therapeutic potential of poly(ADP-ribose)polymerase inhibitors[J].Pharmacol Rev，2002，54(3)：375-429.
[3] Obrosova IG，Pacher P，Szabo C，et al.Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose)polymerase activation in tissue sites for diabetes complications[J].Diabetes，2005，54(1)：234-242.
[4] Yokoi M，Yamagishi S，Takeuchi M，et al.Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy[J].Br J Ophthalmol，2005，89(6)：673-675.
[5] Du Y，Miller CM，KemTS.Hyperglycemia increases mi-tochondrial superoxide in retina and retinal cells[J].Free RadicBiol Med，2003，35(11)：1491-1499.
[6] Kowaltowski AJ，Castilho RF，Vercesi AE.Mitochondrial permeabilitytransition and oxidative stress[J].FEBS Lett，2001， 495(1/2)：12-15.
[7] Kern TS，Tang J，Mizutani M，et al.Response of capillary cell death to aminoguanidine predicts the development of retinopathy：comparison of diabetes and galactosemia[J].Invest Ophthalmol Vis Sci，2000，41(12)：3972-3978.
[8] Podesta F，Romeo G，Liu WH，et al.Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro[J].Am J Pathol，2000，156(3)：1025-1032.
[9] Mohr S，Tang J，Kern TS，et al.Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients[J].Diabetes，2002，51(4)：1172-1179.
[10] Romeo G，Liu WH，Asnaghi V，et al.Activation of nuclear factor-Kappa B induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes[J].Diabetes，2002，51(7)：2241-2248.
[11] 陈永东，许讯.氧化应激在糖尿病视网膜病变中的作用研究进展[J].中华眼底病杂志，2007，23(4)：298-300.
[12] O′Leary VJ，TillingL，FleetwoodG，et al.The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy[J].Atherosclerosis，1996，119(2)：169-179.
[13] Bamhart RL，Busch SJ，Jackson RL.Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro：probucol degradation Precedes lipoprotein oxidation[J].J Lipid Res，1989，30(11)：1703-1710.
[14] Baumstark MW，Aristegui R，Zoller T，et al.Probucol，incorporated into LDL particles in vivo，inhibits generation of lipid peroxides more effectively than endogenous antioxidants alone[J].Clin Biochem，1992，25(5)：395-397.
[15] Masana L，Bargallo MT，Plana N，et al.Effeetiveness of pro-bucolinreducing plasma low-density lipoprotein cholesterol oxidation in hypercholesterolemia[J].Am J Cardiol，1991，68(9)：863-867.
[16] 刘庆淮，谢平，戈应滨，等.一氧化氮及其合成酶在糖尿病视网膜损伤中的作用[J].中华眼科杂志，2005，41(9)：837-841.
(收稿日期：2014-09-12 本文编辑：李亚聪) (蒋苏平)