Notch信号通路在结直肠肿瘤干细胞中的作用(3)
[5] Arrowsmith J.Trial watch： Phase Ⅱ failures： 2008-2010[J].Nat Rev Drug Discov，2011，10(5)：328-329.
[6] Clevers H.The cancer stem cell： premises， promises and challenges[J].Nat Med，2011，17(3)：313-319.
[7] Vaiopoulos AG，Kostakis ID，Koutsilieris M，et al.Colorectal cancer stem cells[J].Stem Cells，2012，30(3)：363-371.
[8] Reya T，Morrison SJ，Clarke MF，et al.Stem cells，cancer，and cancer stem cells[J].Nature，2001，414(6859)：105-l11.
[9] Takebe N，Harris PJ，Warren RQ，et al.Targeting cancer stem cells by inhibiting Wnt，Notch，and Hedgehog pathways[J].Nat Rev Clin Oncol，2011，8：97-106.
[10] Wang Z，Li Y，Ahmad A，et al.Targeting Notch signaling pathway to overcome drug resistance for cancer therapy[J].Biochim Biophys Acta，2010，1806：258-267.
[11] Boman BM，Wicha MS，Fields JZ，et al.Symmetric division of cancer stem cells—a key mechanism in tumor growth that should be targeted in future therapeutic approaches[J].Clin Pharmacol Ther，2007，81(6)：893-898.
[12] Espinoza I，Miele L.Notch inhibitors for cancer treatment[J].Pharmacol Ther，2013，139(2)：95-110.
[13] Bray SJ.Notch signaling：a simple pathway becomes complex[J].Nat Rev Mol Cell Biol，2006，7(9)：678-689.
[14] Capaccione KM，Pine SR.The Notch signaling pathway as a mediator of tumor survival[J].Carcinogenesis，2013，34(7)：1420-1430.
[15] Mumm JS，Kopan R.Notch signaling：from the outside in[J].Dev Biol，2000，228(2)：151-165.
[16] Takebe N，Nguyen D，Yang SX.Targeting notch signaling pathway in cancer：clinical development advances and challenges[J].Pharmacol Ther，2014，141(2)：140-149.
[17] Han J，Hendzel MJ，Allalunis-Turner J.Notch signaling as a therapeutic target for breast cancer treatment？[J].Breast Cancer Res，2011，13(3)：210.
[18] Ranganathan P，Weaver KL，Capobianco AJ.Notch signalling in solid tumours： a little bit of everything but not all the time[J].Nat Rev Cancer，2011，11(5)：338-351.
[19] Wang Z，Li Y，Sarkar FH.Notch signaling proteins： legitimate targets for cancer therapy[J].Curr Protein Pept Sci，2010，11(6)：398-408.
[20] de Sousa EMF，Colak S，Buikhuisen J，et al.Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients[J].Cell Stem Cell，2011，9(5)：476-485.
[21] Grudzien P，Lo S，Albain KS，et al.Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation[J].Anticancer Res，2010，30(10)：3853-3867. (赵小芳 王红)
[6] Clevers H.The cancer stem cell： premises， promises and challenges[J].Nat Med，2011，17(3)：313-319.
[7] Vaiopoulos AG，Kostakis ID，Koutsilieris M，et al.Colorectal cancer stem cells[J].Stem Cells，2012，30(3)：363-371.
[8] Reya T，Morrison SJ，Clarke MF，et al.Stem cells，cancer，and cancer stem cells[J].Nature，2001，414(6859)：105-l11.
[9] Takebe N，Harris PJ，Warren RQ，et al.Targeting cancer stem cells by inhibiting Wnt，Notch，and Hedgehog pathways[J].Nat Rev Clin Oncol，2011，8：97-106.
[10] Wang Z，Li Y，Ahmad A，et al.Targeting Notch signaling pathway to overcome drug resistance for cancer therapy[J].Biochim Biophys Acta，2010，1806：258-267.
[11] Boman BM，Wicha MS，Fields JZ，et al.Symmetric division of cancer stem cells—a key mechanism in tumor growth that should be targeted in future therapeutic approaches[J].Clin Pharmacol Ther，2007，81(6)：893-898.
[12] Espinoza I，Miele L.Notch inhibitors for cancer treatment[J].Pharmacol Ther，2013，139(2)：95-110.
[13] Bray SJ.Notch signaling：a simple pathway becomes complex[J].Nat Rev Mol Cell Biol，2006，7(9)：678-689.
[14] Capaccione KM，Pine SR.The Notch signaling pathway as a mediator of tumor survival[J].Carcinogenesis，2013，34(7)：1420-1430.
[15] Mumm JS，Kopan R.Notch signaling：from the outside in[J].Dev Biol，2000，228(2)：151-165.
[16] Takebe N，Nguyen D，Yang SX.Targeting notch signaling pathway in cancer：clinical development advances and challenges[J].Pharmacol Ther，2014，141(2)：140-149.
[17] Han J，Hendzel MJ，Allalunis-Turner J.Notch signaling as a therapeutic target for breast cancer treatment？[J].Breast Cancer Res，2011，13(3)：210.
[18] Ranganathan P，Weaver KL，Capobianco AJ.Notch signalling in solid tumours： a little bit of everything but not all the time[J].Nat Rev Cancer，2011，11(5)：338-351.
[19] Wang Z，Li Y，Sarkar FH.Notch signaling proteins： legitimate targets for cancer therapy[J].Curr Protein Pept Sci，2010，11(6)：398-408.
[20] de Sousa EMF，Colak S，Buikhuisen J，et al.Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients[J].Cell Stem Cell，2011，9(5)：476-485.
[21] Grudzien P，Lo S，Albain KS，et al.Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation[J].Anticancer Res，2010，30(10)：3853-3867. (赵小芳 王红)