重组表皮生长因子联合莫匹罗星在鼓膜修补术中的临床应用效果(1)
[摘要] 目的 探讨重组表皮生长因子联合莫匹罗星在鼓膜修补术中的临床应用效果。 方法 选择2013年1～12月在本院接受鼓膜修补术治疗的60例患者为研究对象，随机分为2组，各30例，对照组患者行明胶海绵单纯外贴手术，试验组患者行涂有重组表皮生长因子+莫匹罗星混合物的明胶海绵外贴手术，比较两组治疗效果及并发症情况。 结果 试验组治愈率为93.33%，对照组治愈率为86.67%，两组比较，差异无统计学意义(P>0.05)；试验组并发症发生率为3.3%，低于对照组的20%，差异有统计学意义(P<0.05)；两组术后听力改善及鼓膜愈合时间比较，差异有统计学意义(P<0.05)。 结论 鼓膜修补术中应用重组表皮生长因子联合莫匹罗星，能有效促进创面愈合，减少并发症，提高手术成功率。
[关键词] 鼓膜修补术；重组表皮生长因子；莫匹罗星；应用效果
[中图分类号] R764.9+2 [文献标识码] A [文章编号] 1674-4721(2015)05(b)-0100-03
Clinical application effect of recombinant endothelial growth factor combined with mupirocin in myringoplasty
YUAN Zu-jun1 LIU Xiao-fei2
1.Department of Otorhinolaryngology，the First People′s Hospital of Ji′an City in Jiangxi Province，Ji′an 343000，China；2.Department of Otorhinolaryngology，People′s Hospital of Wanan County in Jiangxi Province，Wanan 343800，China
[Abstract] Objective To explore the clinical application effect of recombinant epidermal growth factor (REGF) combined with mupirocin in myringoplasty. Methods 60 patients accepted myringoplasty in our hospital from January to December in 2013 were selected as research objects.They were evenly divided into two groups in random.In control group， patients were treated by external application of gelatin sponge alone，while external application of gelatin sponge covered with REGF combined with mupirocin was adopted to experimental group.The therapeutic effect and complications between two groups was compared respectively. Results The cure rate in experimental group was 93.33%，while in control group，the rate was 86.67%，with no statistical differenc(P>0.05).In experimental group，the incidence of complication was 3.3%，while in control group，the rate was 20%，with statistical difference(P<0.05).In addition，there were statistical differences in postoperative hearing improvement and healing time of tympanic membrane(P<0.05). Conclusion Recombinant endothelial growth factor combined with mupirocin in myringoplasty can effectively promote wound healing and reduce complications and improve the surgical successful rate.
[Key words] Myringoplasty；Recombinant epidermal growth factor (REGF)；Mupirocin；Application effect
传统治疗鼓膜穿孔以早期预防感染、自然愈合为主，易出现中耳化脓性炎症等，造成严重后果[1-2]。为此建议择期行手术治疗，促进创面早期愈合[3-5]。本研究对本院收治的鼓膜穿孔患者行重组表皮生长因子+莫匹罗星外贴法鼓膜修补术，效果明显。
1 资料与方法
1.1 一般资料
选择2013年1～12月在本院行鼓膜修补术治疗的60例鼓膜穿孔患者为研究对象，纳入标准：①中央性穿孔，直径2～4 mm，干耳>半个月；②咽鼓管、鼻咽部检查正常；③听力为混合型或传导性耳聋，气导听阈≤45 dB；④自愿签署知情同意书。排除标准：①颅脑损伤、咽鼓管功能障碍；②感音神经性聋且眩晕；③肝、肾功能严重障碍。其中男性32例，女性28例，年龄20～58岁，平均(40.2±2.5)岁。病因：外伤引起22例，中耳炎引起20例，外界声音刺激引起5例，其他13例。随机将60例患者分为对照组和试验组，各30例，两组患者的性别、年龄、病因等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。 (袁祖均 刘小飞)
[关键词] 鼓膜修补术；重组表皮生长因子；莫匹罗星；应用效果
[中图分类号] R764.9+2 [文献标识码] A [文章编号] 1674-4721(2015)05(b)-0100-03
Clinical application effect of recombinant endothelial growth factor combined with mupirocin in myringoplasty
YUAN Zu-jun1 LIU Xiao-fei2
1.Department of Otorhinolaryngology，the First People′s Hospital of Ji′an City in Jiangxi Province，Ji′an 343000，China；2.Department of Otorhinolaryngology，People′s Hospital of Wanan County in Jiangxi Province，Wanan 343800，China
[Abstract] Objective To explore the clinical application effect of recombinant epidermal growth factor (REGF) combined with mupirocin in myringoplasty. Methods 60 patients accepted myringoplasty in our hospital from January to December in 2013 were selected as research objects.They were evenly divided into two groups in random.In control group， patients were treated by external application of gelatin sponge alone，while external application of gelatin sponge covered with REGF combined with mupirocin was adopted to experimental group.The therapeutic effect and complications between two groups was compared respectively. Results The cure rate in experimental group was 93.33%，while in control group，the rate was 86.67%，with no statistical differenc(P>0.05).In experimental group，the incidence of complication was 3.3%，while in control group，the rate was 20%，with statistical difference(P<0.05).In addition，there were statistical differences in postoperative hearing improvement and healing time of tympanic membrane(P<0.05). Conclusion Recombinant endothelial growth factor combined with mupirocin in myringoplasty can effectively promote wound healing and reduce complications and improve the surgical successful rate.
[Key words] Myringoplasty；Recombinant epidermal growth factor (REGF)；Mupirocin；Application effect
传统治疗鼓膜穿孔以早期预防感染、自然愈合为主，易出现中耳化脓性炎症等，造成严重后果[1-2]。为此建议择期行手术治疗，促进创面早期愈合[3-5]。本研究对本院收治的鼓膜穿孔患者行重组表皮生长因子+莫匹罗星外贴法鼓膜修补术，效果明显。
1 资料与方法
1.1 一般资料
选择2013年1～12月在本院行鼓膜修补术治疗的60例鼓膜穿孔患者为研究对象，纳入标准：①中央性穿孔，直径2～4 mm，干耳>半个月；②咽鼓管、鼻咽部检查正常；③听力为混合型或传导性耳聋，气导听阈≤45 dB；④自愿签署知情同意书。排除标准：①颅脑损伤、咽鼓管功能障碍；②感音神经性聋且眩晕；③肝、肾功能严重障碍。其中男性32例，女性28例，年龄20～58岁，平均(40.2±2.5)岁。病因：外伤引起22例，中耳炎引起20例，外界声音刺激引起5例，其他13例。随机将60例患者分为对照组和试验组，各30例，两组患者的性别、年龄、病因等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。 (袁祖均 刘小飞)