瑞舒伐他汀治疗冠心病合并左心功能不全的临床效果(1)
[摘要] 目的 探讨瑞舒伐他汀对冠心病合并左心功能不全患者的临床疗效。 方法 选择2013年1月～2014年6月本院收治的血脂正常冠心病合并左心功能不全[左心室射血分数(LVEF)<40%]的患者100例，随机分为治疗组50例和对照组50例，对照组给予常规治疗，治疗组在常规治疗的基础上加用瑞舒伐他汀10 mg/次，每晚1次，疗程6个月，比较两组治疗前、治疗6个月的血脂、LVEF、心绞痛发作频率。 结果 治疗6个月治疗组总胆固醇、三酰甘油、低密度脂蛋白胆固醇均低于治疗前，高密度脂蛋白胆固醇高于治疗前，差异有统计学意义(P<0.05)；治疗组治疗前、治疗6个月LVEF分别为(36±7)%、(52±9)%，对照组分别为(32±8)%、(42±7)%，治疗组治疗6个月LVEF高于治疗前，且高于对照组(P<0.05)；治疗组治疗6个月心绞痛发作频率低于治疗前及对照组，两组比较，差异有统计学意义(P<0.05)。 结论 对血脂正常冠心病合并心功能不全的患者，在常规治疗的基础上加用瑞舒伐他汀，可提高LVEF，改善心功能，减少心绞痛的发作频率。
[关键词] 瑞舒伐他汀；冠心病；左心功能不全；临床疗效
[中图分类号] R972 [文献标识码] A [文章编号] 1674-4721(2015)07(c)-0076-03
Clinical efficacy observation of rosuvastatin in the treatment of coronary heart disease with left ventricular dysfunction
XIAO Bin1 HE Zuo-yu2
1.Department of Pharmacy，Yishui Central Hospital in Linyi City of Shandong Province，Linyi 276400，China；2.Department of Cardiovascular，Yishui Central Hospital in Linyi City of Shandong Province，Linyi 276400，China
[Abstract] Objective To discuss clinical curative effect of rosuvastatin calcium on patients with normal blood fat of coronary heart disease(CHD)and left cardiac insufficiency. Methods The patients of normal blood fat of CHD with left cardiac insufficiency(LVEF<40%)were randomly divided into treatment group and the control group，with 50 cases in each group.Treatment group was given conventional treatment combined with rosuvastatin calcium(10 mg/d，1 times a night)for six months；Control group was given conventional treatment only.Blood fat，clinical and echocardiographic index changes between two groups was compared respectively. Results After 6 months of treatment，cholesterol，triglycerides，low density lipoprotein cholesterol in treatment group was lower than that before treatment respectively，with statistical difference(P<0.05).6 months after treatment，LVEF in treatment group was (52±9)%，LVEF in control group was (42±7)%.6 months after treatment，LVEF in treatment group was higher than that before treatment，with statistical difference(P<0.05).6 months after treatment，LVEF in treatment group was higher than that of control group，with statistical difference(P<0.05). Conclusion Routine treatment combined with rosuvastatin calcium can improve LVEF，cardiac function，and reduce the onset frequency of angina.
[Key words] Rosuvastatin；Coronary heart disease；Left ventricular dysfunction；Clinical effect
随着经济水平的迅速发展，人民饮食习惯的改变，及人口老龄化，目前我国冠心病的发病率正在逐年升高，血脂异常是导致冠心病的主要危险因素之一[1]。2007年中国心血管病报告显示，我国每年约300万人死于心血管疾病，其中冠心病是主要死亡原因，且呈明显上升的趋势[2]。研究表明，动脉粥样硬化是冠心病发病的主要病理、生理基础[3]。冠状动脉粥样硬化引起血管狭窄，致使心肌缺血、缺氧而形成的心脏病，心肌长期处于缺血、缺氧状态，心肌细胞变性坏死，易出现心功能不全[4-5]。他汀类药物不仅有调脂作用，还具有抗炎、抗氧化、抗血小板集聚、抗血栓形成及稳定斑块的作用，可降低心肌细胞炎性因子过度激活，扩张血管，改善心肌重构，改善心力衰竭患者的心功能等作用[6]。瑞舒伐他汀为新型的他汀类降脂药物，本研究旨在探讨瑞舒伐他汀对冠心病合并左心功能不全患者左心室射血分数(LVEF)、心功能、心绞痛的发作频率的影响。, 百拇医药(肖斌 贺作玉)
[关键词] 瑞舒伐他汀；冠心病；左心功能不全；临床疗效
[中图分类号] R972 [文献标识码] A [文章编号] 1674-4721(2015)07(c)-0076-03
Clinical efficacy observation of rosuvastatin in the treatment of coronary heart disease with left ventricular dysfunction
XIAO Bin1 HE Zuo-yu2
1.Department of Pharmacy，Yishui Central Hospital in Linyi City of Shandong Province，Linyi 276400，China；2.Department of Cardiovascular，Yishui Central Hospital in Linyi City of Shandong Province，Linyi 276400，China
[Abstract] Objective To discuss clinical curative effect of rosuvastatin calcium on patients with normal blood fat of coronary heart disease(CHD)and left cardiac insufficiency. Methods The patients of normal blood fat of CHD with left cardiac insufficiency(LVEF<40%)were randomly divided into treatment group and the control group，with 50 cases in each group.Treatment group was given conventional treatment combined with rosuvastatin calcium(10 mg/d，1 times a night)for six months；Control group was given conventional treatment only.Blood fat，clinical and echocardiographic index changes between two groups was compared respectively. Results After 6 months of treatment，cholesterol，triglycerides，low density lipoprotein cholesterol in treatment group was lower than that before treatment respectively，with statistical difference(P<0.05).6 months after treatment，LVEF in treatment group was (52±9)%，LVEF in control group was (42±7)%.6 months after treatment，LVEF in treatment group was higher than that before treatment，with statistical difference(P<0.05).6 months after treatment，LVEF in treatment group was higher than that of control group，with statistical difference(P<0.05). Conclusion Routine treatment combined with rosuvastatin calcium can improve LVEF，cardiac function，and reduce the onset frequency of angina.
[Key words] Rosuvastatin；Coronary heart disease；Left ventricular dysfunction；Clinical effect
随着经济水平的迅速发展，人民饮食习惯的改变，及人口老龄化，目前我国冠心病的发病率正在逐年升高，血脂异常是导致冠心病的主要危险因素之一[1]。2007年中国心血管病报告显示，我国每年约300万人死于心血管疾病，其中冠心病是主要死亡原因，且呈明显上升的趋势[2]。研究表明，动脉粥样硬化是冠心病发病的主要病理、生理基础[3]。冠状动脉粥样硬化引起血管狭窄，致使心肌缺血、缺氧而形成的心脏病，心肌长期处于缺血、缺氧状态，心肌细胞变性坏死，易出现心功能不全[4-5]。他汀类药物不仅有调脂作用，还具有抗炎、抗氧化、抗血小板集聚、抗血栓形成及稳定斑块的作用，可降低心肌细胞炎性因子过度激活，扩张血管，改善心肌重构，改善心力衰竭患者的心功能等作用[6]。瑞舒伐他汀为新型的他汀类降脂药物，本研究旨在探讨瑞舒伐他汀对冠心病合并左心功能不全患者左心室射血分数(LVEF)、心功能、心绞痛的发作频率的影响。, 百拇医药(肖斌 贺作玉)