[摘要] 目的 探讨大鼠脑挫裂伤合并硬膜下血肿模型中TNF-α及IL-1β的表达情况。 方法 将120只大鼠随机分为正常组60只和模型组60只。利用球囊内注水后快速解压制作脑挫裂伤合并硬膜下血肿模型，在6、12、24 h，模型组行开颅取脑组织，SP免疫组织化学检测脑组织TNF-α及IL-1β的表达。 结果 6、12、24 h，模型组大鼠脑组织中TNF-α及IL-1β水平显著升高，而正常组对应的TNF-α、IL-1β表达水平则明显降低，两组比较，差异有统计学意义(P<0.05)。 结论 在脑挫裂伤合并硬膜下血肿模型中，TNF-α及IL-1β表达水平在伤后6、12、24 h明显增高，提示出现脑损伤、脑水肿。

    [关键词] 硬膜下血肿；脑外伤；TNF-α；IL-1β

    [中图分类号] R332 [文献标识码] A [文章编号] 1674-4721(2016)01(c)-0105-04

    [Abstract] Objective To explore the expression of TNF-α and IL-1β in cerebral contusion and laceration complicated with subdural hematoma in rats. Methods One hundred and twenty rats were evenly divided into normal group and model group in random.The cerebral contusion and laceration complicated with subdural hematoma model was established by rapid decompression after injecting water using sacculus.Brain tissue was taken by craniotomy at 6 h ......