右美托咪定预防气管插管全身麻醉拟行腹部手术患者术后咽喉疼痛的研究(1)
[摘要]目的 研究右美托咪定对气管插管全身麻醉拟行腹部手术患者术后咽喉疼痛的预防作用。 方法 选取我院2010年12月～2016年3月收治的气管插管全身麻醉拟行腹部手术患者100例，将其随机分为两组(观察组和对照组)，两组患者均采用同种药物进行麻醉，观察组50例患者在手术结束前30 min采用右美托咪定静脉泵入，对照组50例患者采用氯化钠注射液静脉泵入，对比两组患者的咽喉疼痛发生率、拔除气管插管时间、恢复自主呼吸时间。 结果 观察组患者的咽喉疼痛发生率(10.00%)显著低于对照组(40.00%)(P<0.05)，观察组患者的拔除气管插管时间[(12.06±1.54)min]，恢复自主呼吸时间[(5.67±2.85)min]与对照组[(12.12±1.29)，min，(5.69±2.81)min]差异无统计学意义(P>0.05)。 结论 右美托咪定预防咽喉疼痛的效果显著。
[关键词]右美托咪定；腹部手术；咽喉疼痛
[中图分类号] R614.2 [文献标识码] A [文章编号] 1674-4721(2016)10(b)-0104-03
[Abstract]Objective To study the prevention role of Dexmedetomidine on sore throat after operation in patients scheduled for abdominal surgery and given endotracheal intubation and general anesthesia.Methods 100 patients with endotracheal intubation and general anesthesia undergoing abdominal surgery were admitted into the hospital from December 2010 to March 2016 were selected and randomly divided into two groups (observation group and control group)，there were 50 cases in each group.Two groups of patients were treated with the same drug anesthesia.Observation group was administered with constant intravenous infusion of Dexmedetomidine 30 minutes before the completion of the surgery.Control Group was treated with intravenous infusion of sodium chloride injection.The incidence rate of sore throat，extubation time and spontaneous breathing recovery time between two groups was compared respectively.Results The incidence rate of sore throat in observation group (10.00%) was significantly lower than that of control group(40.00%) (P<0.05).the extubation time and spontaneous breathing recovery time of observation group was (12.06±1.54) min and (5.67±2.85) min without significant difference in comparison with control group[(12.12±1.29) min，(5.69±2.81)min] (P>0.05).Conclusion Dexmedetomidine demonstrates its great effectiveness in prevention of sore throat.
[Key words]Dexmedetomidine；Abdominal surgery；Sore throat
全身麻醉是通过静脉应用麻醉药物或者吸入麻醉药物使手术患者全身痛觉消失、意识消失从而配合手术进行的麻醉方式，全身麻醉具有安全性高、稳定性良好等特点，目前在临床上被广泛应用，在全身麻醉发挥其应用价值的过程中，由于术后拔管和气管插管时易损伤患者的气管黏膜，增加其手术治疗后的痛苦，从而严重影响腹部手术效果。目前，我院在气管插管全身麻醉拟行腹部手术患者麻醉中采用两种药物，探讨哪种药物对术后咽喉疼痛具有良好的镇痛效果[1-3]，因此，本院选取100例气管插管全身麻醉拟行腹部手术患者分别采用右美托咪定和氯化钠注射液静脉泵入，为临床全身麻醉用药提供有利依据。
1资料与方法
1.1一般资料
选取我院2010年12月～2016年3月收治的气管插管全身麻醉拟行腹部手术患者100例，将患者采用抽签随机分组方式进行分组，其中50例患者为观察组，50例患者为对照组。纳入标准；①100例患者均接受全身麻醉手术；②排除具有长期精神病史、疼痛病史患者；③排除具有全身麻醉手术禁忌证、严重器质性病变、药物过敏患者；④排除心肺功能不全患者；⑤排除麻醉诱导时插管困难患者。观察组；25例男性，25例女性，年龄30～50岁，平均(40.01±0.34)岁。对照组；26例男性，24例女性，年龄31～50岁，平均(41.24±0.28)岁。两组的性别、年龄等一般资料差异无统计学意义(P>0.05)，具有可比性。 (谢国强 陈银连 张阳连)
[关键词]右美托咪定；腹部手术；咽喉疼痛
[中图分类号] R614.2 [文献标识码] A [文章编号] 1674-4721(2016)10(b)-0104-03
[Abstract]Objective To study the prevention role of Dexmedetomidine on sore throat after operation in patients scheduled for abdominal surgery and given endotracheal intubation and general anesthesia.Methods 100 patients with endotracheal intubation and general anesthesia undergoing abdominal surgery were admitted into the hospital from December 2010 to March 2016 were selected and randomly divided into two groups (observation group and control group)，there were 50 cases in each group.Two groups of patients were treated with the same drug anesthesia.Observation group was administered with constant intravenous infusion of Dexmedetomidine 30 minutes before the completion of the surgery.Control Group was treated with intravenous infusion of sodium chloride injection.The incidence rate of sore throat，extubation time and spontaneous breathing recovery time between two groups was compared respectively.Results The incidence rate of sore throat in observation group (10.00%) was significantly lower than that of control group(40.00%) (P<0.05).the extubation time and spontaneous breathing recovery time of observation group was (12.06±1.54) min and (5.67±2.85) min without significant difference in comparison with control group[(12.12±1.29) min，(5.69±2.81)min] (P>0.05).Conclusion Dexmedetomidine demonstrates its great effectiveness in prevention of sore throat.
[Key words]Dexmedetomidine；Abdominal surgery；Sore throat
全身麻醉是通过静脉应用麻醉药物或者吸入麻醉药物使手术患者全身痛觉消失、意识消失从而配合手术进行的麻醉方式，全身麻醉具有安全性高、稳定性良好等特点，目前在临床上被广泛应用，在全身麻醉发挥其应用价值的过程中，由于术后拔管和气管插管时易损伤患者的气管黏膜，增加其手术治疗后的痛苦，从而严重影响腹部手术效果。目前，我院在气管插管全身麻醉拟行腹部手术患者麻醉中采用两种药物，探讨哪种药物对术后咽喉疼痛具有良好的镇痛效果[1-3]，因此，本院选取100例气管插管全身麻醉拟行腹部手术患者分别采用右美托咪定和氯化钠注射液静脉泵入，为临床全身麻醉用药提供有利依据。
1资料与方法
1.1一般资料
选取我院2010年12月～2016年3月收治的气管插管全身麻醉拟行腹部手术患者100例，将患者采用抽签随机分组方式进行分组，其中50例患者为观察组，50例患者为对照组。纳入标准；①100例患者均接受全身麻醉手术；②排除具有长期精神病史、疼痛病史患者；③排除具有全身麻醉手术禁忌证、严重器质性病变、药物过敏患者；④排除心肺功能不全患者；⑤排除麻醉诱导时插管困难患者。观察组；25例男性，25例女性，年龄30～50岁，平均(40.01±0.34)岁。对照组；26例男性，24例女性，年龄31～50岁，平均(41.24±0.28)岁。两组的性别、年龄等一般资料差异无统计学意义(P>0.05)，具有可比性。 (谢国强 陈银连 张阳连)