丁苯酞软胶囊治疗脑卒中后轻度认知功能障碍的临床效果(1)
[摘要]目的 探讨丁苯酞软胶囊治疗脑卒中后轻度认知功能障碍的临床效果。方法 2016年1～12月，纳入符合研究条件的脑卒中后轻度认知功能障碍患者90例，用双盲法分为观察组和对照组，均给予基础治疗，观察组加丁苯酞软胶囊，对照组加吡拉西坦片，连续治疗14 d。比较两组治疗前后的血浆超氧化物歧化酶(SOD)水平、简易精神状态检查表(MMSE)评分、脑卒中神经功能缺损量表(CSS)评分、日常生活活动能力表(Barthel指数)评分；比较两组的疗效及不良反应。结果 治疗后，观察组的血浆SOD上升且高于对照组，观察组的CSS评分较对照组低，Barthel、MMSE较对照组高；观察组的总有效率(93.33%)较对照组(80.00%)高(均P<0.05)。两组的不良反应发生率差异无统计学意义(P>0.05)。结论 丁苯酞软胶囊能改善脑卒中后轻度认知功能障碍患者认知功能，可减轻神经功能缺损，提高日常生活能力，不良反应少，效果好，值得推广。
[关键词]丁苯酞软胶囊；脑卒中；轻度认知功能障碍
[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721(2017)05(a)-0048-03
[Abstract]Objective To explore the clinical efficacy of Butylphthalide Soft Capsules in the treatment of mild cognitive impairment after stroke.Methods From January to December 2016，90 patients with mild cognitive impairment after stroke meeting the condition were included in the study.The patients were divided into observation group and control group by double-blind method.The patients were treated with basic therapy.The observation group was treated with Butylphthalide Soft Capsules.while the control group was treated by Piracetam and all patients were treated for 14 days.Plasma superoxide dismutase (SOD)，mini mental state examination (MMSE) score，China stroke scale (CSS) score，activities of daily living scale (Barthel index) before and after treatment between two groups were compared.Efficacy and adverse reactions were compared between the two groups.Results After treatment，the level of plasma SOD increased and higher than that of the control group，and CSS score in the observation group was lower than that of control group，and Barthel and MMSE score were higher than those in the control group and the total effective rate (93.33%) in the observation group was higher than that in the control group (80.00%) (P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Butylphthalide Soft Capsules can improve the cognitive function of patients with mild cognitive impairment after stroke，reduce neurological deficits，improve the daily living ability，less adverse reactions，the effect is good，and it is worthy of promotion.
[Key words]Butylphthalide Soft Capsules；Stroke；Mild cognitive dysfunction
腦血管病变是威胁全人类健康的重大疾病，急性脑梗死又被成为缺血性脑卒中，是常见卒中类型之一，具有高病死率、高复发率、高患病率、高致残率等特点。发病后患者语言功能受损，肢体瘫痪，50%～65%的患者伴有不同程度的认知功能障碍，患者有精神行为异常、执行能力降低、失用、失认等症状，使患者日常生活能力集聚下降。及时有效的治疗能促进患者肢体运动功能、神经功能早日康复，预防血管性痴呆，改善患者长期生活质量[1]。丁苯酞是治疗脑卒中的常用药物之一，能通保护细胞线粒体、重构缺血去微循环、改善能量代谢等途径促进神经元及其功能修复。近年来发现该药物用于脑卒中伴认知功能障碍患者中对恢复认知功能有一定帮助[2]。本研究以吡拉西坦片为对照，分析丁苯酞软胶囊治疗脑卒中后轻度认知功能障碍对患者认知功能、神经缺损等的影响，现报道如下。 (沈友进 王丹 万婷玉)
[关键词]丁苯酞软胶囊；脑卒中；轻度认知功能障碍
[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721(2017)05(a)-0048-03
[Abstract]Objective To explore the clinical efficacy of Butylphthalide Soft Capsules in the treatment of mild cognitive impairment after stroke.Methods From January to December 2016，90 patients with mild cognitive impairment after stroke meeting the condition were included in the study.The patients were divided into observation group and control group by double-blind method.The patients were treated with basic therapy.The observation group was treated with Butylphthalide Soft Capsules.while the control group was treated by Piracetam and all patients were treated for 14 days.Plasma superoxide dismutase (SOD)，mini mental state examination (MMSE) score，China stroke scale (CSS) score，activities of daily living scale (Barthel index) before and after treatment between two groups were compared.Efficacy and adverse reactions were compared between the two groups.Results After treatment，the level of plasma SOD increased and higher than that of the control group，and CSS score in the observation group was lower than that of control group，and Barthel and MMSE score were higher than those in the control group and the total effective rate (93.33%) in the observation group was higher than that in the control group (80.00%) (P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Butylphthalide Soft Capsules can improve the cognitive function of patients with mild cognitive impairment after stroke，reduce neurological deficits，improve the daily living ability，less adverse reactions，the effect is good，and it is worthy of promotion.
[Key words]Butylphthalide Soft Capsules；Stroke；Mild cognitive dysfunction
腦血管病变是威胁全人类健康的重大疾病，急性脑梗死又被成为缺血性脑卒中，是常见卒中类型之一，具有高病死率、高复发率、高患病率、高致残率等特点。发病后患者语言功能受损，肢体瘫痪，50%～65%的患者伴有不同程度的认知功能障碍，患者有精神行为异常、执行能力降低、失用、失认等症状，使患者日常生活能力集聚下降。及时有效的治疗能促进患者肢体运动功能、神经功能早日康复，预防血管性痴呆，改善患者长期生活质量[1]。丁苯酞是治疗脑卒中的常用药物之一，能通保护细胞线粒体、重构缺血去微循环、改善能量代谢等途径促进神经元及其功能修复。近年来发现该药物用于脑卒中伴认知功能障碍患者中对恢复认知功能有一定帮助[2]。本研究以吡拉西坦片为对照，分析丁苯酞软胶囊治疗脑卒中后轻度认知功能障碍对患者认知功能、神经缺损等的影响，现报道如下。 (沈友进 王丹 万婷玉)