氟比洛芬酯注射液1mg/kg静脉推注用于腹腔镜阑尾切除术术后疼痛的效果及对血小板聚集功能的影响(1)
[摘要]目的 探討氟比洛芬酯注射液1 mg/kg静脉推注用于腹腔镜阑尾切除术术后疼痛的效果及对血小板聚集功能的影响。方法 将我院2014年2月～2016年12月收治的60例行腔镜阑尾切除术患者按照随机数字法平均分为两组，30例术后清醒后予以生理盐水5 ml静脉推注(对照组)，30例术后清醒后予以氟比洛芬酯注射液1 mg/kg静脉推注(研究组)。比较两组患者用药前(T1)、用药15 min(T2)、用药30 min(T3)、用药1 h(T4)、用药2 h(T5)、用药4 h(T6)、用药6 h(T7)时的静息视觉模拟评分(VAS)、活动VAS评分、小板聚集功能(PAG)，并统计两组的不良反应发生情况。结果 两组患者T1、T2时的静息及活动时VAS评分比较差异无统计学意义(P>0.05)，T3、T4、T5、T6、T7时，研究组静息及活动时的VAS评分较T1时显著降低，且显著低于对照组(P<0.05)。两组患者T1、T2、T3、T4、T5、T6、T7时的PAG水平比较差异无统计学意义(P>0.05)。两组的不良反应发生率比较差异无统计学意义(P>0.05)。结论 给予行腔镜阑尾切除术患者氟比洛芬酯注射液1 mg/kg静脉推注可有效抑制术后疼痛，不会影响患者血小板聚集功能，且无明显不良反应，值得临床推广应用。
[关键词]氟比洛芬酯；腹腔镜阑尾切除术；术后疼痛；血小板聚集功能
[中图分类号] R614.2+4 [文献标识码] A [文章编号] 1674-4721(2017)10(b)-0100-03
[Abstract]Objective To investigate the effect of Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection on postoperative pain after laparoscopic appendectomy and its influence on platelet aggregation function.Methods 60 patients undergoing endoscopic appendectomy admitted into our hospital from February 2014 to December 2016 were evenly divided into two groups according to the random number method.30 patients were given normal saline 5 ml for intravenous injection after postoperative sober (the control group)，and 30 patients were given Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection after postoperative sober (the study group).Resting visual analogue scale (VAS)，active VAS score，and platelet aggregation function (PAG) were compared between the two groups before medication (T1)，after 15 min medication (T2)，after 30 min medication (T3)，after 1 h medication (T4)，after 2 h medication (T5)，after 4 h medication (T6) and after 6 h medication (T7).The incidence of adverse reactions was statistically analyzed in both groups.Results There was no significant difference in VAS score at T1 and T2 during resting and activity in both groups (P>0.05).At T3，T4，T5，T6，T7，VAS score in the study group during resting and activity was significantly decreased，which was significantly lower than that in the control group (P<0.05).There was no significant difference in PAG level at T1，T2，T3，T4，T5，T6 and T7 between the two groups (P>0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).Conclusion Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection in patients receiving laparoscopic appendectomy can effectively inhibit postoperative pain，and will not affect platelet aggregation function，with no significant adverse reactions，which is worthy of promotion and application in clinic., 百拇医药(何光范 马俭发 沈逸飞 徐珊 罗慧君 )
[关键词]氟比洛芬酯；腹腔镜阑尾切除术；术后疼痛；血小板聚集功能
[中图分类号] R614.2+4 [文献标识码] A [文章编号] 1674-4721(2017)10(b)-0100-03
[Abstract]Objective To investigate the effect of Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection on postoperative pain after laparoscopic appendectomy and its influence on platelet aggregation function.Methods 60 patients undergoing endoscopic appendectomy admitted into our hospital from February 2014 to December 2016 were evenly divided into two groups according to the random number method.30 patients were given normal saline 5 ml for intravenous injection after postoperative sober (the control group)，and 30 patients were given Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection after postoperative sober (the study group).Resting visual analogue scale (VAS)，active VAS score，and platelet aggregation function (PAG) were compared between the two groups before medication (T1)，after 15 min medication (T2)，after 30 min medication (T3)，after 1 h medication (T4)，after 2 h medication (T5)，after 4 h medication (T6) and after 6 h medication (T7).The incidence of adverse reactions was statistically analyzed in both groups.Results There was no significant difference in VAS score at T1 and T2 during resting and activity in both groups (P>0.05).At T3，T4，T5，T6，T7，VAS score in the study group during resting and activity was significantly decreased，which was significantly lower than that in the control group (P<0.05).There was no significant difference in PAG level at T1，T2，T3，T4，T5，T6 and T7 between the two groups (P>0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).Conclusion Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection in patients receiving laparoscopic appendectomy can effectively inhibit postoperative pain，and will not affect platelet aggregation function，with no significant adverse reactions，which is worthy of promotion and application in clinic., 百拇医药(何光范 马俭发 沈逸飞 徐珊 罗慧君 )