螺内酯联合甲磺酸氨氯地平片治疗老年高血压心脏病的效果(1)
[摘要]目的 探讨螺内酯联合甲磺酸氨氯地平片治疗老年高血压心脏病的效果。方法 选取2014年1月～2017年1月的我院收治的148例老年高血压心脏病患者，根据随机数字表法将其分为对照组和观察组，每组74例。对照组采取常规治疗和护理，观察组在对照组基础上给予螺内酯联合甲磺酸氨氯地平片治疗。对两组患者治疗前后的血压值(SBP、DBP)、疗效情况以及LVEDVI、LVESVI、LVEDD、IVST和LVPWT指标以及VE/VA、LVEF、Tei指数等指标进行统计分析。结果 治疗前，两组患者的血压差异均无统计学意义(P>0.05)，治疗后，观察组的SBP、DBP水平改善程度显著高于对照组(P<0.05)。观察组的总有效率为86.49%，显著高于对照组的59.46%(P<0.05)。治疗前，两组的LVEDVI、LVESVI、LVEDD、IVST和LVPWT指标以及VE/VA、LVEF、Tei指数等指标差异均无统计学意义(P>0.05)，治疗后，观察组的上述指标均显著改善(P<0.05)，对照组仅LVEDVI、LVESVI和LVEF指标显著改善(P<0.05)，观察组的改善程度均显著高于对照组(P<0.05)。结论 螺内酯联合甲磺酸氨氯地平片可有效改善高血压患者的左心室肥厚和重构，有利于缓解舒张功能障碍，降低血压，保证患者的治疗效果。
[關键词]螺内酯；甲磺酸氨氯地平片；高血压；心室重构
[中图分类号] R541.3 [文献标识码] A [文章编号] 1674-4721(2018)5(a)-0016-04
[Abstract]Objective To investigate the effect of Spironolactone combined with Amlodipine Mesylate Tablets in the treatment of elderly hypertensive heart disease.Methods A total of 148 elderly patients with hypertensive heart disease treated in our hospital from January 2014 to January 2017 were selected and they were divided into the control group (n=74) and the observation group (n=74) according to the random digital table method.The control group was treated with routine treatment and nursing，and the observation group was treated with Spironolactone and Amlodipine Mesylate Tablets on the basis of the control group.The blood pressure (SBP，DBP)，curative effect and LVEDVI，LVESVI，LVEDD，IVST，LVPWT indicators，VE/VA，LVEF，Tei index and other indicators before and after treatment of patients in the two groups were statistically analyzed.Results Before treatment，there is no significant difference in blood pressure between the two groups (P>0.05).After treatment，the improvement of SBP and DBP level of the observation group is significantly higher than that in the control group (P<0.05).The total effective rate of the observation group is 86.49%，which was obviously higher than that of the control group (59.46%) (P<0.05).Before treatment，there are no significant differences in LVEDVI，LVESVI，LVEDD，IVST and VE/VA，LVEF，LVPWT index and Tei index (P>0.05)，after treatment，all parameters in the observation group were significantly improved (P<0.05)，only LVEDVI，LVESVI and LVEF index in the control group were improved significantly (P<0.05)，the degree of improvement in the observation group was higher than that of the control group (P<0.05).Conclusion Spironolactone combined with Amlodipine Mesylate Tablets can effectively improve left ventricular hypertrophy and remodeling in hypertensive patients，is beneficial for relieving diastolic dysfunction，reduce blood pressure，and ensure the treatment effect of patients., 百拇医药(卢丽华 廖通 李焕轮 古振拓)
[關键词]螺内酯；甲磺酸氨氯地平片；高血压；心室重构
[中图分类号] R541.3 [文献标识码] A [文章编号] 1674-4721(2018)5(a)-0016-04
[Abstract]Objective To investigate the effect of Spironolactone combined with Amlodipine Mesylate Tablets in the treatment of elderly hypertensive heart disease.Methods A total of 148 elderly patients with hypertensive heart disease treated in our hospital from January 2014 to January 2017 were selected and they were divided into the control group (n=74) and the observation group (n=74) according to the random digital table method.The control group was treated with routine treatment and nursing，and the observation group was treated with Spironolactone and Amlodipine Mesylate Tablets on the basis of the control group.The blood pressure (SBP，DBP)，curative effect and LVEDVI，LVESVI，LVEDD，IVST，LVPWT indicators，VE/VA，LVEF，Tei index and other indicators before and after treatment of patients in the two groups were statistically analyzed.Results Before treatment，there is no significant difference in blood pressure between the two groups (P>0.05).After treatment，the improvement of SBP and DBP level of the observation group is significantly higher than that in the control group (P<0.05).The total effective rate of the observation group is 86.49%，which was obviously higher than that of the control group (59.46%) (P<0.05).Before treatment，there are no significant differences in LVEDVI，LVESVI，LVEDD，IVST and VE/VA，LVEF，LVPWT index and Tei index (P>0.05)，after treatment，all parameters in the observation group were significantly improved (P<0.05)，only LVEDVI，LVESVI and LVEF index in the control group were improved significantly (P<0.05)，the degree of improvement in the observation group was higher than that of the control group (P<0.05).Conclusion Spironolactone combined with Amlodipine Mesylate Tablets can effectively improve left ventricular hypertrophy and remodeling in hypertensive patients，is beneficial for relieving diastolic dysfunction，reduce blood pressure，and ensure the treatment effect of patients., 百拇医药(卢丽华 廖通 李焕轮 古振拓)
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