消化内镜联合四联疗法治疗胃溃疡出血的临床效果(1)
[摘要]目的 探讨消化内镜联合四联疗法治疗胃溃疡出血的临床效果。方法 选取2014年3月～2018年2月我院收治的80例胃潰疡出血患者作为研究对象，按照随机数字表法将其分为对照组(40例)与观察组(40例)。对照组患者采用四联疗法，观察组患者采用消化内镜联合四联疗法。比较两组患者的疾病症状消失时间、用药时间、细胞因子水平[上表皮生长因素(EGF)、血管内皮生长因子(VEGF)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)]、治疗效果以及再出血情况。结果 观察组患者的疾病症状消失时间为(2.26±0.30)d，用药时间为(5.29±0.51)d，均分别短于对照组[(4.84±1.01)、(8.23±1.24)d]，差异有统计学意义(P<0.05)。两组患者治疗前的EGF、VEGF、SOD、TNF-α水平比较，差异无统计学意义(P>0.05)；两组患者治疗后的EGF、VEGF、SOD水平均高于治疗前，TNF-α水平低于治疗前，差异有统计学意义(P<0.05)；观察组患者治疗后的EGF水平为(315.20±12.34)IU，VEGF水平为(98.56±5.52)IU，SOD水平为(37.45±2.23)IU/L，均分别高于对照组[(223.15±11.10)IU、(81.52±4.26)IU、(30.63±2.01)IU/L]，TNF-α水平为(19.52±2.01)ng/L，低于对照组[(27.45±3.24)ng/L]，差异有统计学意义(P<0.05)。观察组患者的治疗总有效率为95.00%，高于对照组的72.50%，差异有统计学意义(P<0.05)。观察组患者的再出血率为5.00%，低于对照组的35.00%，差异有统计学意义(P<0.05)。结论 胃溃疡出血在四联疗法的基础上，增加消化内镜止血治疗，可以获得更好的止血效果。
[关键词]胃溃疡出血；四联疗法；消化内镜
[中图分类号] R656.6+2 [文献标识码] A [文章编号] 1674-4721(2018)11(a)-0022-03
Clinical effect of digestive endoscopy combined with quadruple therapy on gastric ulcer bleeding
FU Xin YI Jian ZHANG Shan-jin WU Yu-wen
Department of Gastroenterology， People′s Hospital of Yichun City， Jiangxi Province， Yichun 336000， China
[Abstract] Objective To analyze the effect of digestive endoscopy combined with quadruple therapy on gastric ulcer bleeding. Methods Eighty patients with gastric ulcer bleeding admitted to our hospital from March 2014 to February 2018 were selected as the study subjects. They were divided into control group (40 cases) and observation group (40 cases) according to the random number table method. The control group was treated with quadruple therapy， and the observation group was treated with digestive endoscopy combined with quadruple therapy. The disappearance time of the disease symptoms， the time of administration， the levels of cytokines (epidermal growth factor [EGF]， vascular endothelial growth factor [VEGF]， superoxide dismutase [SOD]， tumor necrosis factor-α [TNF-α])， the therapeutic effect， and the rebleeding were compared between the two groups. Results The disappearance time of the disease symptoms in the observation group was (2.26±0.30) d， the medication time was (5.29±0.51) d， which were respectively shorter than those in the control group ([4.84±1.01]， [8.23±1.24] d)， and the differences were statistically significant (P<0.05). There were no significant differences in the levels of EGF， VEGF， SOD and TNF-α before treatment between the two groups (P>0.05). The levels of EGF， VEGF and SOD after treatment were higher than those before treatment， the level of TNF-α was lower than that before treatment， and the differences were statistically significant (P<0.05). The level of EGF in the observation group was (315.20±12.34) IU， the level of VEGF was (98.56±5.52) IU， and the level of SOD was (37.45±2.23) IU/L， which were respectively higher those in the control group ([223.15±11.10] IU， [81.52±4.26] IU， [30.63±2.01] IU/L)， the level of TNF-α in the observation group was (19.52±2.01) ng/L， which was lower than that in the control group ([27.45±3.24] ng/L)， and the differences were statistically significant (P<0.05). The total effective rate of the treatment in the observation group was 95.00%， which was higher than that in the control group (72.50%)， and the difference was statistically significant (P<0.05). The rebleeding rate of the observation group was 5.00%， which was lower than that of the control group (35.00%)， and the difference was statistically significant (P<0.05). Conclusion In the treatment of gastric ulcer bleeding， quadruple therapy combined with endoscopic hemostasis can achieve better hemostatic effect., http://www.100md.com(傅鑫 易健 张善金 吴裕文)
[关键词]胃溃疡出血；四联疗法；消化内镜
[中图分类号] R656.6+2 [文献标识码] A [文章编号] 1674-4721(2018)11(a)-0022-03
Clinical effect of digestive endoscopy combined with quadruple therapy on gastric ulcer bleeding
FU Xin YI Jian ZHANG Shan-jin WU Yu-wen
Department of Gastroenterology， People′s Hospital of Yichun City， Jiangxi Province， Yichun 336000， China
[Abstract] Objective To analyze the effect of digestive endoscopy combined with quadruple therapy on gastric ulcer bleeding. Methods Eighty patients with gastric ulcer bleeding admitted to our hospital from March 2014 to February 2018 were selected as the study subjects. They were divided into control group (40 cases) and observation group (40 cases) according to the random number table method. The control group was treated with quadruple therapy， and the observation group was treated with digestive endoscopy combined with quadruple therapy. The disappearance time of the disease symptoms， the time of administration， the levels of cytokines (epidermal growth factor [EGF]， vascular endothelial growth factor [VEGF]， superoxide dismutase [SOD]， tumor necrosis factor-α [TNF-α])， the therapeutic effect， and the rebleeding were compared between the two groups. Results The disappearance time of the disease symptoms in the observation group was (2.26±0.30) d， the medication time was (5.29±0.51) d， which were respectively shorter than those in the control group ([4.84±1.01]， [8.23±1.24] d)， and the differences were statistically significant (P<0.05). There were no significant differences in the levels of EGF， VEGF， SOD and TNF-α before treatment between the two groups (P>0.05). The levels of EGF， VEGF and SOD after treatment were higher than those before treatment， the level of TNF-α was lower than that before treatment， and the differences were statistically significant (P<0.05). The level of EGF in the observation group was (315.20±12.34) IU， the level of VEGF was (98.56±5.52) IU， and the level of SOD was (37.45±2.23) IU/L， which were respectively higher those in the control group ([223.15±11.10] IU， [81.52±4.26] IU， [30.63±2.01] IU/L)， the level of TNF-α in the observation group was (19.52±2.01) ng/L， which was lower than that in the control group ([27.45±3.24] ng/L)， and the differences were statistically significant (P<0.05). The total effective rate of the treatment in the observation group was 95.00%， which was higher than that in the control group (72.50%)， and the difference was statistically significant (P<0.05). The rebleeding rate of the observation group was 5.00%， which was lower than that of the control group (35.00%)， and the difference was statistically significant (P<0.05). Conclusion In the treatment of gastric ulcer bleeding， quadruple therapy combined with endoscopic hemostasis can achieve better hemostatic effect., http://www.100md.com(傅鑫 易健 张善金 吴裕文)