布地奈德福莫特罗粉吸入剂治疗急性发作期支气管哮喘的效果(1)
[摘要]目的 探讨布地奈德福莫特罗粉吸入剂治疗急性发作期支气管哮喘(BA)的效果。方法 选取2017年4月～2018年10月我院收治的60例急性发作期BA患者作为研究对象，依据随机数字表法将其分为对照组和观察组，每组各30例。对照组给予常规治疗，观察组则采取布地奈德福莫特罗吸入剂的治疗。比较两组的临床治疗效果、治疗期不良反应发生情况与肺功能改善情况。结果 观察组治疗总有效率为93.33%，高于对照组的73.33%(P<0.05)。观察组有咳嗽、胸闷不良反应各1例，不良反应发生率为6.66%(2/30)，低于对照组的30.00%(9/30)(P<0.05)。观察组治疗后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及呼吸气流量峰值(PEF)]高于对照组，差异均有统计学意义(P<0.05)。结论 布地奈德福莫特罗吸入剂对急性发作期BA患者，可显著提升患者的肺功能，不良反应发生率低，效果可靠安全，值得临床借鉴实施。
[关键词]布地奈德福莫特罗粉吸入剂;哮喘;肺功能;临床价值
[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721(2019)10(c)-0088-03
[Abstract] Objective To investigate the effect of Budesonide Formoterol Powder Inhalation on acute attack bronchial asthma(BA). Methods From April 2017 to October 2018， 60 patients with acute attack BA who treated in our hospital were selected as the study subjects. According to random number table method， all patients were divided into control group and observation group， 30 cases in each group. The control group was given routine treatment， while the observation group was treated with Budesonide Formoterol Inhalation. The clinical effect， adverse reactions during treatment and improvement of pulmonary function were compared between the two groups. Results The total effective rate of the observation group was 93.33%， which was higher than that of the control group (73.33%) (P<0.05). The incidence of adverse reactions in the observation group was only 6.66% (2/30)， which was lower than that in the control group (30.00% [9/30]) (P<0.05). The forced expiratory volume in the first second (FEV1)， forced vital capacity (FVC) and peak respiratory flow (PEF) were higher in the lung function index after treatment in the observation group than that in the control group， the differences were statistically significant (P<0.05). Conclusion Budesonide Formoterol Inhalation for patients with acute attack BA can significantly improve the lung function of patients， the incidence of adverse reaction rate is low， the effect is reliable and safe， worthy of clinical reference and implementation.
[Key words] Budesonide Formoterol Powder Inhaler; Asthma; Lung function; Clinical value
哮喘為临床常见的一种呼吸道感染性疾病，其中呼吸困难、反复性气急、咳嗽、气促与喘息等均为临床的主要表现，患者长期反复发作会造成慢性阻塞性肺疾病等严重并发症出现[1-2]。当患者确诊为哮喘时，如未得到及时、有效的治疗，则会严重影响其生命安全[3]。现阶段，临床已将吸入型药物作为治疗哮喘的首要方式，而临床常见的治疗药物包括吸入型糖皮质激素[4]。布地奈德福莫特罗吸入剂属于一种复合型制剂，在治疗效果和安全方面与传统的单纯制剂比较研究仍有待进一步开展。本研究为探究布地奈德福莫特罗吸入剂在治疗哮喘中的应用价值，将我院收治的60例急性发作期支气管哮喘(BA)患者分组后，比较常规治疗与布地奈德福莫特罗吸入剂治疗效果、肺功能和不良反应，以期进一步明确布地奈德福莫特罗吸入剂的应用价值，现报道如下。, http://www.100md.com(付云杰)
[关键词]布地奈德福莫特罗粉吸入剂;哮喘;肺功能;临床价值
[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721(2019)10(c)-0088-03
[Abstract] Objective To investigate the effect of Budesonide Formoterol Powder Inhalation on acute attack bronchial asthma(BA). Methods From April 2017 to October 2018， 60 patients with acute attack BA who treated in our hospital were selected as the study subjects. According to random number table method， all patients were divided into control group and observation group， 30 cases in each group. The control group was given routine treatment， while the observation group was treated with Budesonide Formoterol Inhalation. The clinical effect， adverse reactions during treatment and improvement of pulmonary function were compared between the two groups. Results The total effective rate of the observation group was 93.33%， which was higher than that of the control group (73.33%) (P<0.05). The incidence of adverse reactions in the observation group was only 6.66% (2/30)， which was lower than that in the control group (30.00% [9/30]) (P<0.05). The forced expiratory volume in the first second (FEV1)， forced vital capacity (FVC) and peak respiratory flow (PEF) were higher in the lung function index after treatment in the observation group than that in the control group， the differences were statistically significant (P<0.05). Conclusion Budesonide Formoterol Inhalation for patients with acute attack BA can significantly improve the lung function of patients， the incidence of adverse reaction rate is low， the effect is reliable and safe， worthy of clinical reference and implementation.
[Key words] Budesonide Formoterol Powder Inhaler; Asthma; Lung function; Clinical value
哮喘為临床常见的一种呼吸道感染性疾病，其中呼吸困难、反复性气急、咳嗽、气促与喘息等均为临床的主要表现，患者长期反复发作会造成慢性阻塞性肺疾病等严重并发症出现[1-2]。当患者确诊为哮喘时，如未得到及时、有效的治疗，则会严重影响其生命安全[3]。现阶段，临床已将吸入型药物作为治疗哮喘的首要方式，而临床常见的治疗药物包括吸入型糖皮质激素[4]。布地奈德福莫特罗吸入剂属于一种复合型制剂，在治疗效果和安全方面与传统的单纯制剂比较研究仍有待进一步开展。本研究为探究布地奈德福莫特罗吸入剂在治疗哮喘中的应用价值，将我院收治的60例急性发作期支气管哮喘(BA)患者分组后，比较常规治疗与布地奈德福莫特罗吸入剂治疗效果、肺功能和不良反应，以期进一步明确布地奈德福莫特罗吸入剂的应用价值，现报道如下。, http://www.100md.com(付云杰)