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Survivin 蛋白在大肠癌中的表达及临床意义
http://www.100md.com 2011年2月15日 《中国医学创新》2011年第5期
     【摘要】 目的 研究大肠癌组织中Survivin 蛋白的表达及其临床意义。方法 采用免疫组织化学法检测Survivin蛋白在大肠癌组织中的表达,研究它的表达与大肠癌恶性程度的关系。用SPSS 10.0统计软件进行分析。结果 Survivin蛋白阳性表达率随分化程度的降低而呈现出上升趋势( P<0.05) 。结论 Survivin蛋白的高表达在大肠癌的发生发展中有促进作用,可作为评价大肠肿瘤生物学恶性程度的重要依据。

    【关键词】 大肠癌; Survivin蛋白

    The expression of Survivin in colorectal carcinoma and its clincal significance ZHOU Fei,NING Xiao-ting. Chinese Medical Hospital of Qiqihar City, Qiqihar 161000, China

    【Abstract】 Objective To Study the expression of Survivin in colorectal carcinoma and clinical sighificance.Methods The expression of Survivin was examined by immunohistochemistry in specimens.Samples divided into various teams according to gender,age and clinical stage. Using immunohistochemistry to see the rate of staining. The relationship of the Survivin expression with clinicopathological factors was statistically analyzed. If P<0.05, we realize it is reasonable.Results The Survivin expression was upregulated with decrease of differentiation level in colorectal carcinoma ( P<0.05).Conclusion In colorectal carcinoma,Survivin was upregulated with the decrease of clinicopathological levels. It imply that Survivin will improve the formation of colorectal carcinoma. ......

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