胞二磷胆碱与脑蛋白水解物治疗急性颅脑外伤的疗效比较(1)
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【摘要】目的：在相同常规药物治疗基础上，观察胞二磷胆碱与脑蛋白对急性颅脑外伤患者的疗效。方法：将100例急性颅脑外伤患者随机分为两组，A组加用胞二磷胆碱0.5~1.0 g入250 ml 10%葡萄糖注射液中，1次/d，B组加用脑蛋白水解物10~20 ml入250 ml 10%葡萄糖中，1次/d，14 d为1个疗程。结果：两组GCS评分及临床疗效差异均有统计学意义(P<0.05)。结论：急性颅脑外伤发生后，脑蛋白水解物与胞二磷胆碱相比，运用脑蛋白水解物可更好的保护脑组织，降低颅脑损伤程度，减少并发症，收到更好的疗效。
【关键词】颅脑外伤；脑蛋白水解物；胞二磷胆碱；GCS评分
The Curative Effect Comparision of Cytidine Diphosphate Choline and Cerebroprotein Hydrolysate in the Therapy of Acute brain Injury/ZHANG Xin-zhong，YANG Xiao-ming//Medical Innovation of China，2012，9(10)：011-012
【Abstract】Objective：To investigate the curative effect comparision of cytidine diphosphate choline and Cerebroprotein Hydrolysate in the therapy of brain injury.Methods：Cytidine diphosphate choline and Cerebroprotein Hydrolysate was used in different groups with 100 cases of traumatic brain injury. The 100 patients were divided into tow groups randomly.A group was given 0.5~1.0 g cytidine diphosphate choline which was dissolved in 250 ml 10%GS，qd.The B group was given 10~20 ml Cerebroprotein Hydrolysate which was dissolved in 250 ml 10%GS，qd.The two groups had a 14-day course.Results：The analysis showed that GCS in B group was significantly better than the A group (P<0.05).Conclusion：Cerebroprotein Hydrolysate has better effect than cytidine diphosphate choline in protecting nerve，declining the level of brain injury and decreasing the complications.
【Key words】Brain injury;Cerebroprotein Hydrolysate;Cytidine diphosphate choline;GCS
First-author’s address：Shanxi Medical University，Taiyuan 03001，China
doi：10.3969/j.issn.1674-4985.2012.10.005
随着社会的发展，交通事故、工业意外等事件不断发生，急性颅脑外伤已成为事故发生后最严重的损害，越来越受到大家的关注。其病情变化快，致残率高，若能及早的选取有效的药物，可有效的减轻颅脑损伤引起的严重后遗症，有效提高生活质量。现将胞二磷胆碱和脑蛋白水解物两种药物对急性颅脑外伤患者的疗效进行比较。
1资料与方法
1.1一般资料选取山西医科大学第一医院2010年9月-2011年10月因急性颅脑外伤收入院，并符合单纯颅脑外伤伤后6 h入院标准的患者100例，随机分为两组，A组50例，男38例，女12例，年龄17~66岁，平均(39±4)岁；B组50例，男35例，女15例，年龄16~68岁，平均(41±3)岁。两组治疗前各项指标，如性别比、年龄、受伤时间、格拉斯哥昏迷评分(GCS)等差异均无统计学意义(P>0.05)，具有可比性。详见表1。
表1两组治疗前性别、年龄、GCS评分比较
组别男/女平均年龄(岁)GCS评分(分)
A组(n=50)38/1239±47.74±1.5
B组(n=50)35/1541±37.96±1 ......
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