血清MFGE8与CA125\CEA对乳腺癌诊断价值探讨(1)
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【摘要】目的:探讨血清中MFGE8水平及与乳腺癌诊断的关系。方法:收集62例乳腺癌患者(乳腺癌组)、49例乳腺良性肿瘤患者(良性组)及105例女性健康体检者(对照组)血清,用ELISA方法检测MFGE8水平,采用电化学发光法检测CA125和CEA水平,并对结果进行统计学分析。结果:乳腺癌组患者血清中MFGE8、CA125和CEA水平分别为(6638.5±3529.3)pg/ml、(34.58±31.26)U/ml和(4.39±3.25)ng/ml,MFGE8显著高于其他两组;乳腺癌组MFGE8、CA125和CEA的阳性率分别是65.4%、50.9%和30.3%,联合检测MFGE8、CA125和CEA,检出率可提高至85.3%。结论:血清MFGE8水平可以和CA125、CEA一同作为诊断乳腺癌的指标。
【关键词】乳腺肪球因子8;CA125;CEA;乳腺癌
Diagnostic Value of Serum MFGE8,CA125 and CEA on Breast Cancer/LI Jie-bao,ZHANG Jia-heng//Medical Innovation of China,2012,9(10):082-084
【Abstract】Objective:To discuss the serum level of MFGE8 and the relationship between MFGE8 and diagnosis of breast cancer.Methods:Eenzyme-linked immunosorbent assay was introduced to detect serum level of MFGE8 and electrochemiluminescence immunoassay introduced to detect serum level of CA125 and CEA.Results:The serum levels of MFGE8,CA125 and CEA in patients with breast cancer were (6638.5±3529.3)pg/ml,(34.58±31.26)U/ml and (4.39±3.25)ng/ml respectively,which were significantly higher than others.The positive incidence of MFGE8,CA125 and CEA in patients with breast cancer were 65.4%,50.9% and 30.3%.By combined detection of MFGE8,CA125 and CEA,the positive rate of breast cancer could be greatly improved to 85.3%.Conclusion:The serum level of MFGE8 can be reviewed as a kind of valuable biomarker in the diagnosis of breast cancer,together with CA125 and CEA.
【Key words】MFGE8; CA125;CEA;Breast cancer
First-author’s address:Wuhan NO.1 Hospital,Wuhan 430022,China
doi:10.3969/j.issn.1674-4985.2012.10.050
乳腺癌(breast cancer)早期诊断是提高患者治愈率和降低死亡率的关键。乳腺癌相关肿瘤标志物的研究已取得迅速发展,但寻找特异性强、灵敏度高的理想标志物仍是目前临床医学研究的重点。
乳脂肪球因子8(human milk fat globule EGF factor Ⅷ,MFGE8)最早在小鼠乳房上皮细胞内被发现[1],随后该蛋白在不同的物种内独立地被鉴定出来,并给予了不同的命名[2-5],如BA-46(人)、PAS-6/7或lactadherin(牛)、P47(猪),另外,在小鼠的精子细胞上,该蛋白根据其结构功能也被命名为SED1(Secreted protein containing EGF repeats and Discoidin/F5/8 complement domains 1,SED1)[6]。目前,在乳腺癌患者的血清中发现,MFGE8水平明显高于乳腺良性肿瘤患者和正常人群水平。为此,笔者对乳腺癌患者血清MFGE8、CA125和CEA进行联合检测,探讨其在乳腺癌诊断中的价值。
1资料与方法
1.1一般资料乳腺癌患者62例(乳腺癌组),均为女性,平均年龄57 ......
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