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阿托伐他汀对急性冠脉综合征患者血清CD40L和MMP-9水平的影响(1)
http://www.100md.com 2012年4月15日 王阿兰 丁效华 黄慧燕
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     【摘要】目的:观察阿托伐他汀对急性冠脉综合征(acute coronary syndrome,ACS)患者血清白细胞分化抗原配体40(CD40L)和基质金属蛋白酶-9(MMP-9)水平的影响。方法:将67例ACS患者随机分为他汀治疗组35例(阿托伐他汀20 mg/d)和非他汀治疗组32例。分别于发病24 h内和治疗7 d后测定血清CD40L和MMP-9水平;选取同期健康查体者35例为对照组。结果:治疗前ACS患者血清CD40L和MMP-9水平均较对照组高(P<0.01);ACS患者治疗7 d后CD40L和MMP-9水平均较治疗前降低,且他汀治疗组两者降低程度明显高于非他汀治疗组,差异均有统计学意义(P<0.05);ACS患者血浆CD40L和MMP-9之间成正相关(r=0.52,P<0.001)。结论:ACS患者血清CD40L和MMP-9水平增高,血清CD40L与MMP-9之间成正相关;阿托伐他汀可以降低ACS患者血清CD40L和MMP-9表达,减少冠状动脉粥样斑块炎症反应和基质成分降解,具有稳定斑块作用;ACS患者早期应用他汀类强化治疗可能对患者的治疗效果更好,对进一步预防ACS患者的心脏缺血事件有积极作用。

    【关键词】急性冠脉综合征;白细胞分化抗原配体40;基质金属蛋白酶-9;阿托伐他汀

    The Impact of Atorvastatin on Serum CD40L and MMP-9 Levels of Patients with Acute Coronary Syndrome/WANG A-lan,DING Xiao-hua,HUANG Hui-yan.//Medical Innovation of China,2012,9(11):010-012

    【Abstract】Objective:To observe impact of atorvastatin on leukocyte differentiation antigen ligand 40(CD40L) and matrix metalloproteinase-9(MMP-9) levels of patients with acute coronary syndrome.Methods:67 patients with ACS were randomly divided into statin treatment group(35 cases,atorvastatin,20 mg/d) and non-statin treatment group(32 cases).Serum CD40L and MMP-9 levels were measured within 48 hours after onset and in 7 days after treatment,respectively.Control group were 35 healthy people over the same period.Results:Before treatment,serum CD40L and MMP-9 levels of patients with ACS were higher than those of control group(P<0.01). 7 days after treatment,CD40L and MMP-9 levels of ACS patients decreased,and statin treatment group reduced significantly higher than non-statin treatment group,the differences were statistically significant (p<0.05).CD40L and MMP-9 were positive correlation in ACS patients (r=0.52,P<0.001).Conclusion:Levels of CD40L and MMP-9 in ACS patients increase, CD40L and MMP-9 are positive correlation.Atorvastatin can reduce the expression of serum CD40L and MMP-9 in patients with ACS,and reduced coronary plaque inflammation and matrix component degradation,it can stable plaque.Early statin therapy may enhance outcomes and have a positive effect on prevention of further cardiac ischemic events of ACS patients ......

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