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76例结肠癌临床治疗近期疗效分析(1)
http://www.100md.com 2012年4月15日 张军 帕尔哈提 丁海涛 韩智君
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    参见附件。

     【摘要】目的:探讨结肠癌的优势治疗方案,评价近期疗效。方法:选择本院收治的76例结肠癌患者,按患者意愿分为对照组和观察组各38例,对照组采用单一治疗,即单一手术或单一化疗的方法,观察组采用综合治疗方案,即化疗加手术联合方案,追踪观察6个月,比较两组患者临床症状、卡氏评分和肿瘤标志物情况。结果:观察组患者临床症状改善率、卡氏评分优于对照组,差异有统计学意义(P<0.05),两组患者治疗后肿瘤标志物CEA、CA199较治疗前均明显下降,差异有统计学意义(P<0.01或P<0.05),治疗后观察组肿瘤标志物血清值低于对照组,差异有统计学意义(P<0.05)。结论:综合治疗是治疗结肠癌的有效方法之一,能够提高患者生活质量。

    【关键词】结肠癌;化疗;手术;单一治疗;综合治疗

    Short-term Effect of 76 Patients with Colon cancer/ZHANG Jun,Paerhati,DING Hai-tao,et al.//Medical Innovation of China,2012,9(11):026-027

    【Abstract】Objective :To discuss therapy method of colon cancer and evaluate short-term effect.Methods: 76 patients with colon cancer were divided into two groups,38 patients in the control group were treated with single treatment and 38 patients in the observation group were treated with combined treatment.6 months after treatment, the improvement of symptoms, Kamofsky score and tumor markers were compared between two groups.Results :Improvement of clinical symptoms and Kamofsky score in observation group were better than that in control group(P<0.05).The tumor markers of CEA, CA199 in the two groups were significantly decreased after treatment,the difference was statistically significant(P<0.05). After treatment,serum levels of the tumor marker in observation group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:Comprehensive treatment is an effective method for colon cancer,which can improve the quality of life.

    【Key words】Colon cancer;Chemotherapy;Surgical treatment; Single treatment;Comprehensive treatment

    First-author’s address:The Sixth Affiliated Hospital Xinjiang Medical University,Urumqi 830002,China

    doi:10.3969/j.issn.1674-4985.2012.11.014

    结肠癌是胃肠道常见的恶性肿瘤,其5年生存率仅为45%左右[1],并且在我国发病率呈上升趋势,结肠癌常起病隐匿,尤其在高龄患者,很多患者直到产生较严重的并发症如肠梗阻时才去就诊,这给临床治疗造成极大困难,故结肠癌的早期诊断和及时、正确、高效的治疗尤为重要,本科对结肠癌患者进行了综合治疗,取得了较好疗效,现报告如下。

    1资料与方法

    1.1一般资料本院2009年6月-2011年12月收治的76例结肠癌患者,全部病例均经影像学检查和组织病理检查,依据结肠癌诊断标准[2]确诊。按患者意愿分为对照组和观察组各38例,观察组男25例,女13例,年龄39~71岁,平均(49.5±8.5)岁;病理检查分类为腺癌28例,黏液癌8例,其他2例;临床分期Ⅱ期11例、Ⅲ期15例、Ⅳ期12例。对照组男24例,女14例,年龄41~75岁,平均(52 ......

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