右美托咪啶对维库溴铵靶控输注的起效时间和临床作用时间的影响分析(1)
【摘要】 目的：探讨分析右美托咪啶对维库溴铵靶控输注的起效时间和临床作用时间的影响，以便采取合适的临床方案。方法：选取本院2013年3月-2014年6月结肠癌行气管插管全麻患者60例，将其随机分为对照组和研究组，每组30例。对照组患者给予常规维库溴铵靶控输注，研究组在此基础上加用右美托咪啶。对比两组麻醉前(T0)、持续输注Dex后30 min(T1)、60 min(T2)、手术结束时(T3)的心率(HR)、收缩压(SBP)、舒张压(DBP)，比较两组患者维库溴铵的起效时间、临床作用时间和靶控浓度，以及拔管后肌松残余和呼吸抑制。结果：研究组T1时段及之后各时段的HR、SBP、DBP显著低于对照组(P<0.01)。研究组起效时间与对照组无显著差异(P>0.05)，但临床时效时间和维库溴铵靶控浓度显著降低(P<0.01)，研究组肌松残余发生率明显低于对照组(P<0.01)，而拔管后呼吸抑制未见差异(P>0.05)。结论：右美托咪啶不会影响维库溴铵的起效时间，但会显著延长临床作用时间，并在一定程度上减少维库溴铵用药量。
【关键词】 右美托咪啶； 维库溴铵； 靶控输注
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The Effect of Dexmedetomidine on Onset Time and Reaction Time of Vecuronium Target Controlled Infusion/SUN An-ling，WANG Xin，LIANG Qian，et al.//Medical Innovation of China，2015，12(18)：026-028
【Abstract】 Objective：To explore the effect of Dexmedetomidine on onset time and reaction time of Vecuronium target controlled infusion.Method：60 cases of colon cancer patients undergoing general anesthesia were selected in our hospital from March 2013 to June 2014，they were randomly divided into the control group and the study group，each group had 30 cases.Heart rate(HR)，systolic blood pressure(SBP)，diastolic blood pressure(DBP) were compared between the two groups before anesthesia(T0)，after continuous infusion Dex 30 min (T1)，60 min(T2)，at the end of surgery(T3).Vecuronium onset time，clinical reaction time，target concentration，residual NMB after extubation，and respiratory depression were compared between the two groups.Result：In HR，SBP，DBP，the study group were significantly lower than the control group(P<0.01) at T1 period and after each period.In the onset time，the study group had no significant difference with the control group(P>0.05)，but in the clinical aging time and vecuronium target concentration，the study group was lower than the control group (P<0.01)，in the incidence of residual NMB，the study group was significantly lower than the control group(P<0.01)，but in respiratory depression after extubation，the two groups had no significant difference(P>0.05).Conclusion：Dexmedetomidine does not affect vecuronium onset time but will significantly extend the clinical reaction time and reduce the dosage of vecuronium in a certain extent.
, 百拇医药
【Key words】 Dexmedetomidine； Vecuronium； Target-controlled infusion
First-author’s address：Huizhou Central People’s Hospital，Huizhou 516001，China
doi：10.3969/j.issn.1674-4985.2015.18.009
右美托咪啶是一种高选择性α2肾上腺素受体激动剂，Dex激动α2∶α1受体比例为1620∶1，约是可乐定(α2∶α1=220∶1)的8倍。研究发现，右美托咪啶不影响维库溴铵的起效时间，但可以显著增加其神经肌松阻滞作用。当前，右美托咪啶复合其他药物已经广泛应用于全身麻醉[1-2]。但是，关于右美托咪啶对肌松药的药效影响研究较少，本研究观察右美托咪啶对维库溴铵靶控输注药效学的影响，并对其作用机理进行探讨，为临床推广应用提供理论依据。现报道如下。, 百拇医药(孙岸灵 王鑫 梁倩 罗德兴)
【关键词】 右美托咪啶； 维库溴铵； 靶控输注
, http://www.100md.com
The Effect of Dexmedetomidine on Onset Time and Reaction Time of Vecuronium Target Controlled Infusion/SUN An-ling，WANG Xin，LIANG Qian，et al.//Medical Innovation of China，2015，12(18)：026-028
【Abstract】 Objective：To explore the effect of Dexmedetomidine on onset time and reaction time of Vecuronium target controlled infusion.Method：60 cases of colon cancer patients undergoing general anesthesia were selected in our hospital from March 2013 to June 2014，they were randomly divided into the control group and the study group，each group had 30 cases.Heart rate(HR)，systolic blood pressure(SBP)，diastolic blood pressure(DBP) were compared between the two groups before anesthesia(T0)，after continuous infusion Dex 30 min (T1)，60 min(T2)，at the end of surgery(T3).Vecuronium onset time，clinical reaction time，target concentration，residual NMB after extubation，and respiratory depression were compared between the two groups.Result：In HR，SBP，DBP，the study group were significantly lower than the control group(P<0.01) at T1 period and after each period.In the onset time，the study group had no significant difference with the control group(P>0.05)，but in the clinical aging time and vecuronium target concentration，the study group was lower than the control group (P<0.01)，in the incidence of residual NMB，the study group was significantly lower than the control group(P<0.01)，but in respiratory depression after extubation，the two groups had no significant difference(P>0.05).Conclusion：Dexmedetomidine does not affect vecuronium onset time but will significantly extend the clinical reaction time and reduce the dosage of vecuronium in a certain extent.
, 百拇医药
【Key words】 Dexmedetomidine； Vecuronium； Target-controlled infusion
First-author’s address：Huizhou Central People’s Hospital，Huizhou 516001，China
doi：10.3969/j.issn.1674-4985.2015.18.009
右美托咪啶是一种高选择性α2肾上腺素受体激动剂，Dex激动α2∶α1受体比例为1620∶1，约是可乐定(α2∶α1=220∶1)的8倍。研究发现，右美托咪啶不影响维库溴铵的起效时间，但可以显著增加其神经肌松阻滞作用。当前，右美托咪啶复合其他药物已经广泛应用于全身麻醉[1-2]。但是，关于右美托咪啶对肌松药的药效影响研究较少，本研究观察右美托咪啶对维库溴铵靶控输注药效学的影响，并对其作用机理进行探讨，为临床推广应用提供理论依据。现报道如下。, 百拇医药(孙岸灵 王鑫 梁倩 罗德兴)