替米沙坦联合螺内酯预防阵发性心房颤动射频消融术后早期复发的疗效(1)
【摘要】 目的:探讨替米沙坦联合螺内酯预防阵发性心房颤动射频消融术后早期复发的临床疗效。方法:选择本院96例行射频消融术的阵发性心房颤动患者,随机分为观察组和对照组,每组各48例。观察组给予替米沙坦联合螺内酯治疗,对照组给予华法林及胺碘酮治疗。结果:观察组复发率为6.25%,对照组为22.92%,两组比较差异有统计学意义(P<0.05)。观察组术后1个月hsCRP高于对照组,术后3个月观察组NT-proBNP低于对照组,两组比较差异均有统计学意义(P<0.05)。结论:替米沙坦联合螺内酯预防阵发性心房颤动射频消融术后,可减少房颤早期复发。
【关键词】 替米沙坦; 螺内酯; 阵发性心房颤动; 射频消融术; 早期复发
The Effect of Telmisartan Combined Therapy with Spironolactone Prevents Early Recurrence after Catheter Ablation for Paroxysmal Atrial Fibrillation/HU Wei,WANG Li-li.//Medical Innovation of China,2015,12(18):152-153
, 百拇医药
【Abstract】 Objective:To clarify the effects of Telmisartan combined with Spironolactone on early recurrence after catheter ablation for paroxysmal atrial fibrillation in patients.Method:96 patients with PAF treated by catheter ablation were randomly divided into control group and observational group,48 cases in each group,the control group was treated with Warfarin and Amiodarone,the observational group was treated with Telmisartan and Spironolactone.Result:The rate of PAF early recurrence in observational group was 6.25%,which was significantly lower than 22.92% of the control group,the difference was statistically significant (P<0.05).After surgery 1 month,HsCRP in observational group was higher than the control group;after surgery 3 month,NT-proBNP in observational group was lower than the control group,the differences were statistically significant (P<0.05).Conclusion:Telmisartan combined with Spironolactone reduce early recurrence after catheter ablation of PAF.
, 百拇医药
【Key words】 Telmisartan; Spironolactone; Paroxysmal atrial fibrillation; Catheter ablation; Early recurrence
First-author’s address:Sun Yixian Cardiovascular Hospital of Shenzhen,Shenzhen 518000,China
doi:10.3969/j.issn.1674-4985.2015.18.058
心房颤动(房颤)是最常见的心律失常,可增加心血管事件的发生率和死亡率[1]。药物和导管射频消融手术是治疗阵发性房颤的常用方法。近年来,临床选择射频消融手术的患者增加,但术后容易早期复发,据报道,术后3个月内有35%~45%的患者复发[2]。如何减少房颤复发是临床医生面临的问题。本院2012年2月-2014年2月对48例行射频消融术的阵发性心房颤动患者采用替米沙坦联合螺内酯预防心房颤动,效果满意。
, 百拇医药
1 资料与方法
1.1 一般资料 选择本院2012年2月-2014年2月收治的96例行射频消融术的阵发性心房颤动患者,随机分为观察组和对照组,每组各48例。观察组48例中,男29例,女19例,年龄37~73岁,平均(62.76±4.19)岁;对照组48例中,男30例,女18例,年龄39~71岁,平均(63.34±4.21)岁。两组患者性别、年龄等一般资料比较差异无统计学意义(P>0.05)。排除先天性心脏疾病、严重肝肾功能不全、免疫性疾病、有精神病史。
1.2 方法 对照组术后给予华法林及胺碘酮治疗,观察组给予替米沙坦20~80 mg/d,螺内酯20 mg/d。
1.3 统计学处理 使用SPSS 17.0软件进行处理,计量资料用(x±s)表示,比较采用t检验,计数资料用 字2检验,以P<0.05为差异有统计学意义。
2 结果
2.1 两组复发情况比较 观察组术后3个月内房颤复发3例,复发率为6.25%,平均复发时间(83.31±6.18)d;对照组48例中,复发11例,复发率为22.92%,平均复发时间(71.42±6.32)d,对照组复发率高于观察组、复发时间短于观察组,两组比较差异有统计学意义( 字2=5.35,t=9.32,P<0.05)。, 百拇医药(胡伟 王丽丽)
【关键词】 替米沙坦; 螺内酯; 阵发性心房颤动; 射频消融术; 早期复发
The Effect of Telmisartan Combined Therapy with Spironolactone Prevents Early Recurrence after Catheter Ablation for Paroxysmal Atrial Fibrillation/HU Wei,WANG Li-li.//Medical Innovation of China,2015,12(18):152-153
, 百拇医药
【Abstract】 Objective:To clarify the effects of Telmisartan combined with Spironolactone on early recurrence after catheter ablation for paroxysmal atrial fibrillation in patients.Method:96 patients with PAF treated by catheter ablation were randomly divided into control group and observational group,48 cases in each group,the control group was treated with Warfarin and Amiodarone,the observational group was treated with Telmisartan and Spironolactone.Result:The rate of PAF early recurrence in observational group was 6.25%,which was significantly lower than 22.92% of the control group,the difference was statistically significant (P<0.05).After surgery 1 month,HsCRP in observational group was higher than the control group;after surgery 3 month,NT-proBNP in observational group was lower than the control group,the differences were statistically significant (P<0.05).Conclusion:Telmisartan combined with Spironolactone reduce early recurrence after catheter ablation of PAF.
, 百拇医药
【Key words】 Telmisartan; Spironolactone; Paroxysmal atrial fibrillation; Catheter ablation; Early recurrence
First-author’s address:Sun Yixian Cardiovascular Hospital of Shenzhen,Shenzhen 518000,China
doi:10.3969/j.issn.1674-4985.2015.18.058
心房颤动(房颤)是最常见的心律失常,可增加心血管事件的发生率和死亡率[1]。药物和导管射频消融手术是治疗阵发性房颤的常用方法。近年来,临床选择射频消融手术的患者增加,但术后容易早期复发,据报道,术后3个月内有35%~45%的患者复发[2]。如何减少房颤复发是临床医生面临的问题。本院2012年2月-2014年2月对48例行射频消融术的阵发性心房颤动患者采用替米沙坦联合螺内酯预防心房颤动,效果满意。
, 百拇医药
1 资料与方法
1.1 一般资料 选择本院2012年2月-2014年2月收治的96例行射频消融术的阵发性心房颤动患者,随机分为观察组和对照组,每组各48例。观察组48例中,男29例,女19例,年龄37~73岁,平均(62.76±4.19)岁;对照组48例中,男30例,女18例,年龄39~71岁,平均(63.34±4.21)岁。两组患者性别、年龄等一般资料比较差异无统计学意义(P>0.05)。排除先天性心脏疾病、严重肝肾功能不全、免疫性疾病、有精神病史。
1.2 方法 对照组术后给予华法林及胺碘酮治疗,观察组给予替米沙坦20~80 mg/d,螺内酯20 mg/d。
1.3 统计学处理 使用SPSS 17.0软件进行处理,计量资料用(x±s)表示,比较采用t检验,计数资料用 字2检验,以P<0.05为差异有统计学意义。
2 结果
2.1 两组复发情况比较 观察组术后3个月内房颤复发3例,复发率为6.25%,平均复发时间(83.31±6.18)d;对照组48例中,复发11例,复发率为22.92%,平均复发时间(71.42±6.32)d,对照组复发率高于观察组、复发时间短于观察组,两组比较差异有统计学意义( 字2=5.35,t=9.32,P<0.05)。, 百拇医药(胡伟 王丽丽)