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微小RNA与心脏电重构的研究进展(3)
http://www.100md.com 2015年6月25日 《中国医学创新》 2015年第18期
     综上所述,miRNA与电重构关系密切,与心律失常的发病机制紧密相关。电重构是心肌电生理特性重塑的过程,心房电重构与房性心律失常(房速、房颤等)关系密切,心室电重构可产生潜在致命室性心律失常(多形性室速、室颤)。认识电重构的细胞与分子机制对于探明潜在治疗靶标十分重要,miRNA介导的离子通道的变化在心肌电重构过程中发挥重要作用,人类中miRNA数量可能高达20 000种,参与30%的人类基因调控,维持心肌细胞正常的电生理网络需要这些miRNA处于动态平衡,一旦平衡被打破,离子通道蛋白表达改变,就会诱发心律失常的发生。因此,miRNA的分子靶向治疗将成为心律失常领域新的研究方向。

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    (收稿日期:2015-01-15) (本文编辑:陈丹云), 百拇医药(刘长召 王玲 陈文江 陈灿)
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