乌司他丁治疗小儿重症急性胰腺炎的疗效观察(1)
【摘要】 目的：探讨分析乌司他丁治疗小儿重症急性胰腺炎的疗效。方法：选取本院2011年1月-2015年
1月收治的70例重症急性胰腺炎儿童作为研究对象，按照治疗方式的不同将其分为观察组和对照组，每组各35例。对照组给予单纯常规治疗，观察组在常规治疗的基础上加用乌司他丁，比较两组的治疗效果以及IL-6、IL-10含量。结果：经治疗后，观察组总有效率为97.14%，对照组总有效率为57.14%，两组比较差异有统计学意义(P<0.05)；观察组的IL-6下降速度明显快于对照组，IL-10升高速度也显著快于对照组，两组比较差异均有统计学意义(P<0.05)。结论：乌司他丁治疗小儿重症急性胰腺炎效果显著，能明显的抑制炎性反应蛋白CRP，通过调节IL-6、IL-10等细胞因子含量促使病情好转，值得临床推广和应用。
【关键词】 小儿； 重症急性胰腺炎； 乌司他丁； 疗效
【Abstract】 Objective： To investigate the effect of Ulinastatin in the treatment of severe acute pancreatitis in children.Method：70 children with severe acute pancreatitis were selected as the research objects from January 2011 to January 2015，according to the different treatment modalities，they were divided into the observation group and the control group ，35 cases in each group. The control group was given routine treatment，the observation group on the basis of conventional therapy was given Ulinastatin.The therapeutic effect， the content of IL-10 and IL-6 of the two groups were compared. Result： After treatment， the total effective rate of the observation group was 97.14%， the control group was 57.14%，the difference between two groups was statistically significant(P< 0.05)；the dropping speed of IL-6 in the observation group was significantly faster than that in the control group and the increasing speed of IL-10 was significantly faster than the control group， the differences were statistically significant(P<0.05).Conclusion：The effect of Ulinastatin in the treatment of children with severe acute pancreatitis is significant，can significantly inhibit inflammatory reaction protein (CRP)， through the regulation of IL-6 and IL-10 cytokine content prompting condition improved，it is worthy of the clinical promotion and application.
, 百拇医药
【Key words】 Children； Severe acute pancreatitis； Ulinastatin； Curative effect
First-author’s address：The People’s Hospital of Yichun，Yichun 336000，China
doi：10.3969/j.issn.1674-4985.2015.35.040
目前，临床上使用乌司他丁对症治疗SPA取得显著成效，乌司他丁是从人体尿液中提取的广谱蛋白酶抑制剂，抑制全身炎症反应，保护内皮细胞，进而促进特异性免疫细胞功能恢复[1-3]。为了探讨分析乌司他丁治疗小儿重症急性胰腺炎的疗效，本院特选取符合临床诊断标准的SPA儿童患者作为为研究对象应用乌司他丁，现报告如下。
1 资料与方法
, 百拇医药
1.1 一般资料 选取本院2011年1月-2015年1月收治的70例重症急性胰腺炎儿童，按照治疗方式的不同将其分为观察组和对照组，每组各35例。观察组中，男18例，女17例，年龄4个月～5岁，平均(2.50±1.21)岁；对照组中，男16例，女19例，年龄4个月～5岁，平均(2.10±1.12)岁，所有患儿均符合2003年《中国急性胰腺炎诊治指南》诊断标准[4]。通过查体得知，BP：117/66 mm Hg，RR：26次/min，HR：115次/min，患儿面色苍灰，较烦躁，神志欠清，心音律齐、有力，全腹有压痛。经腹部CT检查得知，胰腺体积边缘模糊不清，增大明显，周围肝周、脾周均见液性密度影。经胸片检查得知，胸腔积液，患儿血淀粉酶高，剧烈腹痛，血性腹水。两组患儿的年龄、性别等一般资料比较差异均无统计学意义(P>0.05)，具有可比性。, 百拇医药(李欣)
1月收治的70例重症急性胰腺炎儿童作为研究对象，按照治疗方式的不同将其分为观察组和对照组，每组各35例。对照组给予单纯常规治疗，观察组在常规治疗的基础上加用乌司他丁，比较两组的治疗效果以及IL-6、IL-10含量。结果：经治疗后，观察组总有效率为97.14%，对照组总有效率为57.14%，两组比较差异有统计学意义(P<0.05)；观察组的IL-6下降速度明显快于对照组，IL-10升高速度也显著快于对照组，两组比较差异均有统计学意义(P<0.05)。结论：乌司他丁治疗小儿重症急性胰腺炎效果显著，能明显的抑制炎性反应蛋白CRP，通过调节IL-6、IL-10等细胞因子含量促使病情好转，值得临床推广和应用。
【关键词】 小儿； 重症急性胰腺炎； 乌司他丁； 疗效
【Abstract】 Objective： To investigate the effect of Ulinastatin in the treatment of severe acute pancreatitis in children.Method：70 children with severe acute pancreatitis were selected as the research objects from January 2011 to January 2015，according to the different treatment modalities，they were divided into the observation group and the control group ，35 cases in each group. The control group was given routine treatment，the observation group on the basis of conventional therapy was given Ulinastatin.The therapeutic effect， the content of IL-10 and IL-6 of the two groups were compared. Result： After treatment， the total effective rate of the observation group was 97.14%， the control group was 57.14%，the difference between two groups was statistically significant(P< 0.05)；the dropping speed of IL-6 in the observation group was significantly faster than that in the control group and the increasing speed of IL-10 was significantly faster than the control group， the differences were statistically significant(P<0.05).Conclusion：The effect of Ulinastatin in the treatment of children with severe acute pancreatitis is significant，can significantly inhibit inflammatory reaction protein (CRP)， through the regulation of IL-6 and IL-10 cytokine content prompting condition improved，it is worthy of the clinical promotion and application.
, 百拇医药
【Key words】 Children； Severe acute pancreatitis； Ulinastatin； Curative effect
First-author’s address：The People’s Hospital of Yichun，Yichun 336000，China
doi：10.3969/j.issn.1674-4985.2015.35.040
目前，临床上使用乌司他丁对症治疗SPA取得显著成效，乌司他丁是从人体尿液中提取的广谱蛋白酶抑制剂，抑制全身炎症反应，保护内皮细胞，进而促进特异性免疫细胞功能恢复[1-3]。为了探讨分析乌司他丁治疗小儿重症急性胰腺炎的疗效，本院特选取符合临床诊断标准的SPA儿童患者作为为研究对象应用乌司他丁，现报告如下。
1 资料与方法
, 百拇医药
1.1 一般资料 选取本院2011年1月-2015年1月收治的70例重症急性胰腺炎儿童，按照治疗方式的不同将其分为观察组和对照组，每组各35例。观察组中，男18例，女17例，年龄4个月～5岁，平均(2.50±1.21)岁；对照组中，男16例，女19例，年龄4个月～5岁，平均(2.10±1.12)岁，所有患儿均符合2003年《中国急性胰腺炎诊治指南》诊断标准[4]。通过查体得知，BP：117/66 mm Hg，RR：26次/min，HR：115次/min，患儿面色苍灰，较烦躁，神志欠清，心音律齐、有力，全腹有压痛。经腹部CT检查得知，胰腺体积边缘模糊不清，增大明显，周围肝周、脾周均见液性密度影。经胸片检查得知，胸腔积液，患儿血淀粉酶高，剧烈腹痛，血性腹水。两组患儿的年龄、性别等一般资料比较差异均无统计学意义(P>0.05)，具有可比性。, 百拇医药(李欣)