化学发光法定量检测术前四项传染性标志物的结果分析(1)
【摘要】 目的：了解术前患者乙型肝炎病毒、丙型肝炎病毒、梅毒螺旋体和人类免疫缺陷病毒的携带状况，防止医疗机构院内感染与医疗纠纷的出现。方法：选择意大利索灵LIAISON XL化学发光免疫检验系统，针对2016年入院行手术治疗的8496例患者，术前对乙型肝炎病毒表面抗原(HBsAg)、丙型肝炎病毒抗体(抗-HCV)、梅毒螺旋体特异性抗体(抗-TP)、人类免疫缺陷病毒抗体(抗-HIV)这四种传染性标志物展开定量检验。结果：乙型肝炎病毒表面抗原(HBsAg)呈现阳性的数量是1023例，在全部病例中占12.04%；而丙型肝炎病毒抗体(抗-HCV)呈现阳性的病例数量为48例，在所有病例中占0.56%；梅毒螺旋体特异性抗体(抗-TP)呈现阳性病例数量是129例，在所有病例中占1.52%；人类免疫缺陷病毒抗体(抗-HIV)呈现阳性的病例数量是11例，在所有病例中占0.13%。其中男性的抗-HCV、抗-TP感染率均高于女性(P<0.05)；21～40岁的HBsAg阳性率明显高于其他年龄段(P<0.05)；>60岁的抗-TP阳性率明显高于其他年龄段(P<0.05)。结论：检验术前患者血清传染性标志物，能够对其自身的身体情况有一个充分的了解，避免医院感染，对于医务工作者的自我防范意识的提升有所帮助，有效降低了医疗纠纷发生率。
【关键词】 术前； 化学发光法； 乙型肝炎病毒表面抗原； 丙型肝炎病毒抗体； 梅毒螺旋体特异性抗体； 人类免疫缺陷病毒抗体
【Abstract】 Objective：To understand the preoperative patients with hepatitis B virus，hepatitis C virus，treponema pallidum，human immunodeficiency virus carrying conditions，to avoid and prevent hospital infection and medical disputes.Method：The Italian Diasorin LIAISON XL chemiluminescence immunoassay system was adopted to test hepatitis B virus surface antigen(HBsAg)，hepatitis C virus antibody(anti-HCV) and treponema pallidum antibody(anti-TP)，human immunodeficiency virus(HIV) antibody (anti-HIV) four infectious markers of 8496 preoperative patients.Result：The number of Hepatitis B virus surface antigen(HBsAg) positive were 1023 cases(12.04%)；hepatitis c virus antibody(anti-HCV) positive were 48 cases(0.56%)；specificity of treponema pallidum antibody(anti-TP) positive were 129 cases(1.52%)；human immunodeficiency virus(HIV) antibody(anti-HIV) positive were 11 cases(0.13%)；the rate of anti-HCV and anti-TP infection in male was higher than those in female (P<0.05)；the positive rate of HBsAg in 21-40 years was higher than those in other age group (P<0.05)；the positive rate of anti-TP more than 60 years old was higher than those of other age groups(P<0.05).Conclusion：It is possible to detect the current health status of patients and prevent nosocomial infection，which is beneficial to the self-protection of medical staff and reduce medical disputes.
【Key words】 Preoperation； Chemiluminescence； Hepatitis B virus surface antigen； Hepatitis C virus antibody； Treponema pallidum specific antibody； Human immunodeficiency virus antibody
First-author’s address：The Third People’s Hospital of Dongguan City，Dongguan 523326，China
doi：10.3969/j.issn.1674-4985.2017.21.013
眾所周知，患者手术前的抗体必检项目分别是乙型肝炎病毒表面抗原(HBsAg)、丙型肝炎病毒抗体(抗-HCV)、梅毒螺旋体特异性抗体(抗-TP)、人类免疫缺陷病毒抗体(抗-HIV)，俗称“术前四项”[1-3]。进行这一检测的原因主要是为了避免可能的医源性感染、避免不必要的纠纷、加强医护工作者的自身认知。原来这几项传染性标志物的检测所依赖的技术便是常用的酶联免疫吸附试验(ELISA)，现今，化学发光法(CLIA)进行检测的应用越来越多，这是因为与ELISA相比更为精准、灵活，也具备较高的特异性。本研究采用CLIA法对8496例术前患者四项血清传染性标志物进行检测，现报道如下。, 百拇医药(何英爱 姚叶林 刘见欢)
【关键词】 术前； 化学发光法； 乙型肝炎病毒表面抗原； 丙型肝炎病毒抗体； 梅毒螺旋体特异性抗体； 人类免疫缺陷病毒抗体
【Abstract】 Objective：To understand the preoperative patients with hepatitis B virus，hepatitis C virus，treponema pallidum，human immunodeficiency virus carrying conditions，to avoid and prevent hospital infection and medical disputes.Method：The Italian Diasorin LIAISON XL chemiluminescence immunoassay system was adopted to test hepatitis B virus surface antigen(HBsAg)，hepatitis C virus antibody(anti-HCV) and treponema pallidum antibody(anti-TP)，human immunodeficiency virus(HIV) antibody (anti-HIV) four infectious markers of 8496 preoperative patients.Result：The number of Hepatitis B virus surface antigen(HBsAg) positive were 1023 cases(12.04%)；hepatitis c virus antibody(anti-HCV) positive were 48 cases(0.56%)；specificity of treponema pallidum antibody(anti-TP) positive were 129 cases(1.52%)；human immunodeficiency virus(HIV) antibody(anti-HIV) positive were 11 cases(0.13%)；the rate of anti-HCV and anti-TP infection in male was higher than those in female (P<0.05)；the positive rate of HBsAg in 21-40 years was higher than those in other age group (P<0.05)；the positive rate of anti-TP more than 60 years old was higher than those of other age groups(P<0.05).Conclusion：It is possible to detect the current health status of patients and prevent nosocomial infection，which is beneficial to the self-protection of medical staff and reduce medical disputes.
【Key words】 Preoperation； Chemiluminescence； Hepatitis B virus surface antigen； Hepatitis C virus antibody； Treponema pallidum specific antibody； Human immunodeficiency virus antibody
First-author’s address：The Third People’s Hospital of Dongguan City，Dongguan 523326，China
doi：10.3969/j.issn.1674-4985.2017.21.013
眾所周知，患者手术前的抗体必检项目分别是乙型肝炎病毒表面抗原(HBsAg)、丙型肝炎病毒抗体(抗-HCV)、梅毒螺旋体特异性抗体(抗-TP)、人类免疫缺陷病毒抗体(抗-HIV)，俗称“术前四项”[1-3]。进行这一检测的原因主要是为了避免可能的医源性感染、避免不必要的纠纷、加强医护工作者的自身认知。原来这几项传染性标志物的检测所依赖的技术便是常用的酶联免疫吸附试验(ELISA)，现今，化学发光法(CLIA)进行检测的应用越来越多，这是因为与ELISA相比更为精准、灵活，也具备较高的特异性。本研究采用CLIA法对8496例术前患者四项血清传染性标志物进行检测，现报道如下。, 百拇医药(何英爱 姚叶林 刘见欢)