探讨出生体重≤2 500 g的早产儿口服益生菌对其胃肠功能与生长发育的影响(1)
【摘要】 目的：探討口服益生菌对≤2 500 g的极低出生体重早产儿生长发育和胃肠功能的影响。方法：选取本院2015年2月-2017年3月期间收治的112例极低出生体重早产儿，根据随机数字法分为试验组和对照组，每组各56例。试验组早产儿采用益生菌治疗，对照组采用常规治疗，对比两组胃肠功能、喂养结果与生长发育情况。结果：试验组极低出生体重早产儿体重最大下降率、呼吸暂停、喂养不耐受、坏死性小肠结肠炎、恢复出生体重时间、黄疸持续时间、住院时间和出院时体重等喂养结果与对照组比较均改善，差异均有统计学意义(P<0.05)；试验组胎便排尽时间、留置胃管时间与达全肠喂养时间分别为(5.04±1.75)、(10.26±3.68)、(15.46±2.01)d，明显优于对照组，比较差异均有统计学意义(P<0.05)；试验组生理性体质量下降幅度、恢复出生体质量速度分别为(8.53±3.02)%、(10.86±1.22)g/d，明显优于对照组，比较差异均有统计学意义(P<0.05)。结论：极低出生体重早产儿的喂养结果可通过口服益生菌显著改善，胃肠功能和生长发育情况也能够得到明显改善，值得推广。
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【关键词】 极低出生体重早产儿； 益生菌； 胃肠功能； 影响
【Abstract】 Objective：To investigate the effect of oral probiotics on gastrointestinal function and growth development of premature infants with birth weight ≤2 500 g.Method：According to the random number method，112 patients who were admitted to the hospital between February 2015 and March 2017 were extremely low birth weight preterm infants.They were divided into experimental group and control group，56 cases in each group.The experimental group was treated with probiotics，the control group was treated with conventional treatment.The gastrointestinal function，feeding results and the growth and development of two groups were compared.Result：Experimental group very low birth weight of premature infants weight of the maximum rate of decline，apnea，feeding intolerance，necrotizing enterocolitis，recovery of birth weight time，jaundice duration，the length of stay and body weight at discharge were better than those in the control group.The difference was statistically significant(P<0.05).The time of fecal excretion，gastric tube retention and total enteral feeding in the experimental group were (5.04±1.75)days and (10.26±3.68)days，(15.46±2.01)days，obviously better than the control group，the differences were statistically significant(P<0.05).The decrease of physiologic body mass in the experimental group was(8.53±3.02)%，and the recovery rate was(10.86±1.22) g/d，which was significantly better than those in the control group.The differences were statistically significant(P<0.05).Conclusion：The feeding results of premature infants with very low birth weight can be significantly improved by oral probiotics，and the gastrointestinal function and growth and development can also be significantly improved，which is worthy spreading.
【Key words】 Extremely low birth weight preterm； Probiotics； Gastrointestinal function； Influence
First-author’s address：Wuhan Xinhua Hospital of Hubei，Wuhan 430015，China
doi：10.3969/j.issn.1674-4985.2018.04.014, 百拇医药(周辉)
, http://www.100md.com
【关键词】 极低出生体重早产儿； 益生菌； 胃肠功能； 影响
【Abstract】 Objective：To investigate the effect of oral probiotics on gastrointestinal function and growth development of premature infants with birth weight ≤2 500 g.Method：According to the random number method，112 patients who were admitted to the hospital between February 2015 and March 2017 were extremely low birth weight preterm infants.They were divided into experimental group and control group，56 cases in each group.The experimental group was treated with probiotics，the control group was treated with conventional treatment.The gastrointestinal function，feeding results and the growth and development of two groups were compared.Result：Experimental group very low birth weight of premature infants weight of the maximum rate of decline，apnea，feeding intolerance，necrotizing enterocolitis，recovery of birth weight time，jaundice duration，the length of stay and body weight at discharge were better than those in the control group.The difference was statistically significant(P<0.05).The time of fecal excretion，gastric tube retention and total enteral feeding in the experimental group were (5.04±1.75)days and (10.26±3.68)days，(15.46±2.01)days，obviously better than the control group，the differences were statistically significant(P<0.05).The decrease of physiologic body mass in the experimental group was(8.53±3.02)%，and the recovery rate was(10.86±1.22) g/d，which was significantly better than those in the control group.The differences were statistically significant(P<0.05).Conclusion：The feeding results of premature infants with very low birth weight can be significantly improved by oral probiotics，and the gastrointestinal function and growth and development can also be significantly improved，which is worthy spreading.
【Key words】 Extremely low birth weight preterm； Probiotics； Gastrointestinal function； Influence
First-author’s address：Wuhan Xinhua Hospital of Hubei，Wuhan 430015，China
doi：10.3969/j.issn.1674-4985.2018.04.014, 百拇医药(周辉)
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