受胆固醇调节的变异剪接体及其意义(3)
[2] Paulina B，Billadeau D D，Robert F，et al.CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL[J].Nature Communications，2016，7：10961.
[3] Matsui M，Sakurai F，Elbashir S，et al.Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter[J].Chemistry & Biology，2010，17(12)：1344-1355.
[4] Sonawane P J，Sahu B S，Sasi B K，et al.Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension[J].PLoS One，2011，6(1)：e16661.
, 百拇医药
[5] Hwang S，Hartman I Z，Calhoun L N，et al.Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver[J].Journal of Biological Chemistry，2016，291(26)：13479.
[6] Medina M W，Gao F，Ruan W，et al.Alternative Splicing of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Is Associated With Plasma Low-Density Lipoprotein Cholesterol Response to Simvastatin[J].Circulation，2008，118(4)：355.
, 百拇医药
[7] DeBose-Boyd R A.Feedback regulation of cholesterol synthesis：sterol-accelerated ubiquitination and degradation of HMG CoA reductase[J].Cell Res，2008，18(6)：609-621.
[8] Loregger A，Raaben M，Tan J，et al.Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis[J].Arterioscler Thromb Vasc Biol，2017，37(11)：2064-2074.
[9] Vannice J C，Skaff D A，Wyckoff G J，et al.Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea[J].Journal of Bacteriology，2013，195(17)：3854-3862.
, 百拇医药
[10] Mathews E S，Mawdsley D J，Walker M，et al.Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest， Axon Wrapping， and Myelin Gene Expression[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience，2014，34(9)：3402.
[11] Lee Y，Rio D C.Mechanisms and Regulation of Alternative Pre-mRNA Splicing[J].Annual Review of Biochemistry，2015，84(84)：291.
, 百拇医药
[12] Tveten K，Ranheim T，Berge K E，et al. Analysis of alternatively spliced isoforms of human LDL receptor mRNA[J].Clin Chim Acta，2006，373(1-2)：151-157.
[13] Gil G，Smith J R，Goldstein J L，et al.Optional exon in the 5’-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene：conserved sequence and splicing pattern in humans and hamsters[J].Proceedings of the National Academy of Sciences of the United States of America，1987，84(7)：1863., 百拇医药(庞亚娜 赵晋枫 董元坤)
[3] Matsui M，Sakurai F，Elbashir S，et al.Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter[J].Chemistry & Biology，2010，17(12)：1344-1355.
[4] Sonawane P J，Sahu B S，Sasi B K，et al.Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension[J].PLoS One，2011，6(1)：e16661.
, 百拇医药
[5] Hwang S，Hartman I Z，Calhoun L N，et al.Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver[J].Journal of Biological Chemistry，2016，291(26)：13479.
[6] Medina M W，Gao F，Ruan W，et al.Alternative Splicing of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Is Associated With Plasma Low-Density Lipoprotein Cholesterol Response to Simvastatin[J].Circulation，2008，118(4)：355.
, 百拇医药
[7] DeBose-Boyd R A.Feedback regulation of cholesterol synthesis：sterol-accelerated ubiquitination and degradation of HMG CoA reductase[J].Cell Res，2008，18(6)：609-621.
[8] Loregger A，Raaben M，Tan J，et al.Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis[J].Arterioscler Thromb Vasc Biol，2017，37(11)：2064-2074.
[9] Vannice J C，Skaff D A，Wyckoff G J，et al.Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea[J].Journal of Bacteriology，2013，195(17)：3854-3862.
, 百拇医药
[10] Mathews E S，Mawdsley D J，Walker M，et al.Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest， Axon Wrapping， and Myelin Gene Expression[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience，2014，34(9)：3402.
[11] Lee Y，Rio D C.Mechanisms and Regulation of Alternative Pre-mRNA Splicing[J].Annual Review of Biochemistry，2015，84(84)：291.
, 百拇医药
[12] Tveten K，Ranheim T，Berge K E，et al. Analysis of alternatively spliced isoforms of human LDL receptor mRNA[J].Clin Chim Acta，2006，373(1-2)：151-157.
[13] Gil G，Smith J R，Goldstein J L，et al.Optional exon in the 5’-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene：conserved sequence and splicing pattern in humans and hamsters[J].Proceedings of the National Academy of Sciences of the United States of America，1987，84(7)：1863., 百拇医药(庞亚娜 赵晋枫 董元坤)
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