左西孟旦联合多巴酚丁胺对脓毒血症患者心功能及脑钠肽、超敏C反应蛋白的影响(1)
【摘要】 目的：探讨左西孟旦联合多巴酚丁治疗脓毒血症的效果，观察其对患者心功能及脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)的影响。方法：将2016年1月-2017年10月因脓毒血症并发心功能不全于本院就诊的80例患者纳入研究，按照随机数字表法分为对照组与观察组，每组40例。对照组采用多巴酚丁胺治疗，观察组联合左西孟旦，治疗7 d后，比较两组hs-CRP、BNP等指标改善情况，比较两组左室射血分数(LVEF)、每搏输出量(SV)等心功能指标改善，比较两组临床疗效情况。结果：治疗后，观察组hs-CRP、BNP均低于对照组，观察组LVEF、SV均高于对照组，观察组总有效率95.00%(38/40)高于对照组的77.50%(31/40)，差异均有统计学意义(P<0.05)。结论：左西孟旦联合多巴酚丁胺治疗脓毒血症效果显著，可改善患者心功能，降低炎症反应，促进疾病康复，值得推广。
【关键词】 多巴酚丁胺； 左西孟旦； 脓毒血症； 脑钠肽； 心功能； 超敏C反应蛋白
, 百拇医药 Effect of Levosimendan Combined with Dobutamine on Cardiac Function，Brain Natriuretic Peptide and High-sensitivity C-reactive Protein in Patients with Sepsis/XU Aiping，HE Xianli.//Medical Innovation of China，2018，15(12)：031-034
【Abstract】 Objective：To investigate the effect of Levosimendan combined with Dobutamine in the treatment of sepsis and its effect on the cardiac function，brain natriuretic peptide(BNP) and high-sensitivity C-reactive protein(hs-CRP).Method：A total of 80 patients with sepsis and cardiac insufficiency in our hospital from January 2016 to October 2017 were divided into control group and observation group，40 cases in each group.The control group was treated with Dobutamine，the observation group was treated combined with Levosimendan.BNP and hs-CRP and were compared between two groups after treatment for 7 days.The left ventricular ejection fraction(LVEF)，stroke volume Output(SV) and other cardiac function，the clinical efficacy of two groups were compared.Result：After treatment，hs-CRP and BNP levels in the observation group were lower than those in the control group，LVEF and SV in the observation group were higher than those in the control group，the total effective rate in the observation group(95.00%，38/40)was higher than that in the control group(77.50%，31/40)，the differences were statistically significant(P<0.05).Conclusion：Levosimendan combined with Dobutamine is effective in treating sepsis，which can improve the cardiac function，reduce the inflammatory reaction and promote the recovery of the disease，it is worthy of promotion.
, 百拇医药
【Key words】 Dobutamine； Levosimendan； Sepsis； Brain natriuretic peptide； Cardiac function；
High-sensitivity C-reactive protein
First-author’s address：Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine，Wuhan 430015，China
doi：10.3969/j.issn.1674-4985.2018.12.009
膿毒血症是感染、严重创伤等的常见并发症，可累及机体各器官，引起感染性休克而危及生命[1]。感染是形成脓毒血症的基础，研究表明一旦发生脓毒血症，预后较差，可使心肌收缩力降低，心排血量降低而诱发急性左心衰，其比例约占所有脓毒血症患者的50%[2-3]。治疗方面，抗感染、利尿剂、正性肌力药、扩血管药等药物联合应用具有重要意义，但可增大心肌耗氧量，不利于心功能恢复[4]。左西孟旦是新型钙离子增敏剂，较传统正性肌力药物而言可使更多患者临床获益，从而改善预后，但目前相关研究报道尚少。本文将2016年1月-2017年10月因脓毒血症并发心功能不全于本院就诊的80例患者纳入研究，对左西孟旦联合多巴酚丁胺的疗效进行观察，现报道如下。, 百拇医药(徐爱平 贺贤丽)
【关键词】 多巴酚丁胺； 左西孟旦； 脓毒血症； 脑钠肽； 心功能； 超敏C反应蛋白
, 百拇医药 Effect of Levosimendan Combined with Dobutamine on Cardiac Function，Brain Natriuretic Peptide and High-sensitivity C-reactive Protein in Patients with Sepsis/XU Aiping，HE Xianli.//Medical Innovation of China，2018，15(12)：031-034
【Abstract】 Objective：To investigate the effect of Levosimendan combined with Dobutamine in the treatment of sepsis and its effect on the cardiac function，brain natriuretic peptide(BNP) and high-sensitivity C-reactive protein(hs-CRP).Method：A total of 80 patients with sepsis and cardiac insufficiency in our hospital from January 2016 to October 2017 were divided into control group and observation group，40 cases in each group.The control group was treated with Dobutamine，the observation group was treated combined with Levosimendan.BNP and hs-CRP and were compared between two groups after treatment for 7 days.The left ventricular ejection fraction(LVEF)，stroke volume Output(SV) and other cardiac function，the clinical efficacy of two groups were compared.Result：After treatment，hs-CRP and BNP levels in the observation group were lower than those in the control group，LVEF and SV in the observation group were higher than those in the control group，the total effective rate in the observation group(95.00%，38/40)was higher than that in the control group(77.50%，31/40)，the differences were statistically significant(P<0.05).Conclusion：Levosimendan combined with Dobutamine is effective in treating sepsis，which can improve the cardiac function，reduce the inflammatory reaction and promote the recovery of the disease，it is worthy of promotion.
, 百拇医药
【Key words】 Dobutamine； Levosimendan； Sepsis； Brain natriuretic peptide； Cardiac function；
High-sensitivity C-reactive protein
First-author’s address：Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine，Wuhan 430015，China
doi：10.3969/j.issn.1674-4985.2018.12.009
膿毒血症是感染、严重创伤等的常见并发症，可累及机体各器官，引起感染性休克而危及生命[1]。感染是形成脓毒血症的基础，研究表明一旦发生脓毒血症，预后较差，可使心肌收缩力降低，心排血量降低而诱发急性左心衰，其比例约占所有脓毒血症患者的50%[2-3]。治疗方面，抗感染、利尿剂、正性肌力药、扩血管药等药物联合应用具有重要意义，但可增大心肌耗氧量，不利于心功能恢复[4]。左西孟旦是新型钙离子增敏剂，较传统正性肌力药物而言可使更多患者临床获益，从而改善预后，但目前相关研究报道尚少。本文将2016年1月-2017年10月因脓毒血症并发心功能不全于本院就诊的80例患者纳入研究，对左西孟旦联合多巴酚丁胺的疗效进行观察，现报道如下。, 百拇医药(徐爱平 贺贤丽)