中国医学创新目次小剂量丙戊酸钠防治小儿复杂性热性惊厥的效果研究(1)
【摘要】 目的：研究与分析小剂量丙戊酸钠防治小儿复杂性热性惊厥的效果。方法：选取本院2014年1月-2017年12月收治的小儿复杂性热性惊厥患儿200例为对象进行研究，将其随机分为对照组和观察组，每组各100例。对照组采用小剂量安定治疗，观察组采用小剂量丙戊酸钠治疗。比较分析两组退热时间、止惊时间、治疗效果、不良反应、情况等。结果：观察组退热时间、止惊时间等与对照组相比显著较短，比较差异均有统计学意义(P<0.05)。观察组治疗有效率为94.0%与对照组74.0%相比显著较高，比较差异有统计学意义(P<0.05)。观察组不良反应发生率6.0%、复发率4.0%与对照组22.0%、18.0%相比均显著较低，比较差异均有统计学意义(P<0.05)。结论：小剂量丙戊酸钠防治小儿复杂性热性惊厥的效果非常显著，既能快速改善患儿各种症状，又能减少各种不良反应，还能降低其复发率，因而安全性较高，值得应用推广。
【关键词】 小儿复杂性热性惊厥； 小剂量丙戊酸钠； 防治效果
【Abstract】 Objective：To study and analyze the effect of small doses of sodium valproate in the prevention and treatment of complex febrile seizures in children.Method：A total of 200 children with febrile complex febrile convulsions admitted to our hospital from January 2014 to December 2017 were selected for study.They were randomly divided into control group and observation group，100 cases in each group.A small dose of valproate was used to treat children in the control group.Small doses of sodium valproate was used to treat in the observation group.The two groups were compared and analyzed for the time of fever，the time of scare，the effect of treatment， adverse reactions，and conditions.Result：The duration of fever and the time of start-up in the observation group were significantly shorter than those in the control group(P<0.05).The therapeutically effective rate in the observation group was 94.0% compared with 74.0% in the control group， which was significantly higher(P<0.05).The incidence of adverse reactions in the observation group was 6.0%， and the recurrence rate was 4.0%， which were significantly lower than those in the control group of 22.0% and 18.0%(P<0.05).Conclusion：The effect of low-dose sodium valproate on prevention of complex febrile convulsions in children is very significant.It can not only rapidly improve various symptoms of children， but also reduce various adverse reactions， and can also reduce the recurrence rate.Therefore， it is safer and worthy of application promotion.
【Key words】 Pediatric complexity febrile convulsions； Low dose sodium valproate； Control effect
First-author’s address：Dongguan People’s Hospital，Dongguan 523000，China
doi：10.3969/j.issn.1674-4985.2018.22.015
在臨床儿科中，比较常见的神经性疾病即为小儿复杂性热性惊厥，其一般在6个月～3岁儿童群体中具有较高发病率，由于儿童年龄的增长，其发病率逐渐下降[1-2]。该病症主要特点为发病急、病情进展迅速，如果患儿治疗不及时，则其大脑会出现永久性损伤，且会造成一系列严重后遗症，从而严重威胁患儿的生命健康[3]。以往临床治疗此类患儿时，主要采用的药物为安定，其可对患儿症状有效控制，但由于其要求较高的血药浓度，一旦剂量不合适，则患儿易发生一系列不良反应[4]。而作为一种广谱抗惊厥药物，丙戊酸钠可显著改善患儿症状，且可降低患儿不良反应，还能有效减少其病情复发[5]。因此本文即对小剂量丙戊酸钠防治小儿复杂性热性惊厥的效果进行了研究与分析，现具体报道如下。, http://www.100md.com(王宁 袁慧珍 邸晓华 徐小娟 伍少霞 何妙莎)
【关键词】 小儿复杂性热性惊厥； 小剂量丙戊酸钠； 防治效果
【Abstract】 Objective：To study and analyze the effect of small doses of sodium valproate in the prevention and treatment of complex febrile seizures in children.Method：A total of 200 children with febrile complex febrile convulsions admitted to our hospital from January 2014 to December 2017 were selected for study.They were randomly divided into control group and observation group，100 cases in each group.A small dose of valproate was used to treat children in the control group.Small doses of sodium valproate was used to treat in the observation group.The two groups were compared and analyzed for the time of fever，the time of scare，the effect of treatment， adverse reactions，and conditions.Result：The duration of fever and the time of start-up in the observation group were significantly shorter than those in the control group(P<0.05).The therapeutically effective rate in the observation group was 94.0% compared with 74.0% in the control group， which was significantly higher(P<0.05).The incidence of adverse reactions in the observation group was 6.0%， and the recurrence rate was 4.0%， which were significantly lower than those in the control group of 22.0% and 18.0%(P<0.05).Conclusion：The effect of low-dose sodium valproate on prevention of complex febrile convulsions in children is very significant.It can not only rapidly improve various symptoms of children， but also reduce various adverse reactions， and can also reduce the recurrence rate.Therefore， it is safer and worthy of application promotion.
【Key words】 Pediatric complexity febrile convulsions； Low dose sodium valproate； Control effect
First-author’s address：Dongguan People’s Hospital，Dongguan 523000，China
doi：10.3969/j.issn.1674-4985.2018.22.015
在臨床儿科中，比较常见的神经性疾病即为小儿复杂性热性惊厥，其一般在6个月～3岁儿童群体中具有较高发病率，由于儿童年龄的增长，其发病率逐渐下降[1-2]。该病症主要特点为发病急、病情进展迅速，如果患儿治疗不及时，则其大脑会出现永久性损伤，且会造成一系列严重后遗症，从而严重威胁患儿的生命健康[3]。以往临床治疗此类患儿时，主要采用的药物为安定，其可对患儿症状有效控制，但由于其要求较高的血药浓度，一旦剂量不合适，则患儿易发生一系列不良反应[4]。而作为一种广谱抗惊厥药物，丙戊酸钠可显著改善患儿症状，且可降低患儿不良反应，还能有效减少其病情复发[5]。因此本文即对小剂量丙戊酸钠防治小儿复杂性热性惊厥的效果进行了研究与分析，现具体报道如下。, http://www.100md.com(王宁 袁慧珍 邸晓华 徐小娟 伍少霞 何妙莎)
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