吸入用乙酰半胱氨酸溶液联合普米克令舒在先天性心脏病患儿体外循环术后气道管理中的应用(1)
【摘要】 目的：探討吸入用乙酰半胱氨酸溶液联合普米克令舒在先天性心脏病患儿体外循环术后气道管理中的应用。方法：选取2018年5月-2019年2月于本院进行房间隔缺损或室间隔缺损修补术的80例先天性心脏病患儿为研究对象，按照随机数字表法分为观察组和对照组，每组各40例。对照组采用常规治疗，观察组在对照组基础上联合吸入用乙酰半胱氨酸溶液和普米克令舒进行治疗，两组患儿均连续治疗1周。比较两组患儿症状体征持续时间、血气指标、临床疗效以及不良反应发生情况。结果：观察组临床症状及体征(面唇发绀、气促、喘憋及肺部喘鸣音)持续时间均低于对照组(P<0.05);观察组治疗后的氧分压(PaO2)和氧合指数(OI)均高于对照组，并且二氧化碳分压(PaCO2)低于对照组(P<0.05);观察组总有效率高于对照组，并且不良反应发生率低于对照组(P<0.05)。结论：吸入用乙酰半胱氨酸溶液联合普米克令舒可快速的缓解先天性心脏病患儿体外循环术后的临床症状，改善患儿的呼吸功能，同时该治疗方案不良反应少，保证了治疗的安全性，值得在临床上推广应用。
【关键词】 吸入用乙酰半胱氨酸溶液 普米克令舒 先天性心脏病患儿体外循环术后 气道管理
[Abstract] Objective： To investigate the application of Acetylcysteine Solution for Inhalation combined with Pulmicort Respules in airway management after cardiopulmonary bypass in children with congenital heart disease. Method： A total of 80 children with congenital heart disease who underwent repair of atrial septal defect or ventricular septal defect in our hospital from May 2018 to February 2019 were selected as the study objects. They were divided into observation group and control group by the random number table method， 40 cases in each group. The control group was treated with conventional treatment， the observation group was treated with Acetylcysteine Solution for Inhalation and Pulmicort Respules on the basis of the control group. All the children in the two groups were treated continuously for 1 week. The duration of symptoms and signs， blood gas index， clinical efficacy and adverse reactions occurred were compared in the two groups. Result： The duration of clinical symptoms and signs (face lip cyanosis， shortness of breath， wheezing and lung wheezing) in the observation group were lower than those of the control group (P<0.05). The oxygen partial pressure (PaO2) of the observation group after treatment and the oxygenation index (OI) were higher than those of the control group， and the partial pressure of carbon dioxide (PaCO2) was lower than that of the control group (P<0.05). The total effective rate of the observation group was higher than that of the control group， and the incidence of adverse reactions was lower than that of the control group (P<0.05). Conclusion： Acetylcysteine Solution for Inhalation combined with Pulmicort Respules can quickly alleviate the clinical symptoms of children with congenital heart disease after cardiopulmonary bypass， improve the respiratory function of children， and the treatment program has fewer adverse reactions， which guarantees the safety of treatment and is worthy of clinical application., http://www.100md.com(郭晨 艾凌云 丁琰)
【关键词】 吸入用乙酰半胱氨酸溶液 普米克令舒 先天性心脏病患儿体外循环术后 气道管理
[Abstract] Objective： To investigate the application of Acetylcysteine Solution for Inhalation combined with Pulmicort Respules in airway management after cardiopulmonary bypass in children with congenital heart disease. Method： A total of 80 children with congenital heart disease who underwent repair of atrial septal defect or ventricular septal defect in our hospital from May 2018 to February 2019 were selected as the study objects. They were divided into observation group and control group by the random number table method， 40 cases in each group. The control group was treated with conventional treatment， the observation group was treated with Acetylcysteine Solution for Inhalation and Pulmicort Respules on the basis of the control group. All the children in the two groups were treated continuously for 1 week. The duration of symptoms and signs， blood gas index， clinical efficacy and adverse reactions occurred were compared in the two groups. Result： The duration of clinical symptoms and signs (face lip cyanosis， shortness of breath， wheezing and lung wheezing) in the observation group were lower than those of the control group (P<0.05). The oxygen partial pressure (PaO2) of the observation group after treatment and the oxygenation index (OI) were higher than those of the control group， and the partial pressure of carbon dioxide (PaCO2) was lower than that of the control group (P<0.05). The total effective rate of the observation group was higher than that of the control group， and the incidence of adverse reactions was lower than that of the control group (P<0.05). Conclusion： Acetylcysteine Solution for Inhalation combined with Pulmicort Respules can quickly alleviate the clinical symptoms of children with congenital heart disease after cardiopulmonary bypass， improve the respiratory function of children， and the treatment program has fewer adverse reactions， which guarantees the safety of treatment and is worthy of clinical application., http://www.100md.com(郭晨 艾凌云 丁琰)