赵忠梅 焦晓路

    【摘要】 卵巢癌是女性最致命的恶性肿瘤，有多种信号通路参与其的形成。PI3K/AKT通路可调控细胞内一系列重要的生物学活动，包括细胞的生长，增殖，转录等，该信号通路异常往往导致细胞异常增殖、肿瘤转移以及产生耐药性等重要生物过程的改变。miR-22通过靶向NLRP3抑制PI3K/AKT信号通路。本文将miR-22、NLRP3在卵巢癌中影响PI3K/AKT信号通路的研究进展做一综述，为卵巢癌的靶向治疗提供新的方向和思路。

    【关键词】 miR-22 NLRP3 PI3K/AKT 卵巢癌 信号通路

    [Abstract] Ovarian cancer is the most deadly malignant tumor in women， and multiple signaling pathways are involved in its formation. PI3K/AKT pathway can regulate a series of important biological activities in cells， including cell growth， proliferation， transcription， etc. Abnormal signaling pathway often leads to changes in important biological processes such as abnormal cell proliferation， tumor metastasis and drug resistance. miR-22 inhibits the PI3K/AKT signaling pathway by targeting NLRP3. This paper reviews the research progress of miR-22 and NLRP3 affecting PI3K / Akt signaling pathway in ovarian cancer， so as to provide new directions and ideas for targeted therapy of ovarian cancer.

    [Key words] miR-22 NLRP3 PI3K/AKT Ovarian cancer Signaling pathways

    First-author’s address： Juancheng People’s Hospital ......