【摘要】 危重症疾病往往伴随着全身炎症反应综合征，此期间活性氧及一氧化氮等氧化产物增加，而抗氧化剂浓度降低。失衡的氧化应激反应可导致细胞、组织和器官损伤，增加危重患者的死亡率。维生素D(VD)作为人体新陈代谢所必需的营养物质，在诸多生理过程中发挥着重要作用，而且VD在辅助治疗危重症疾病方面的作用也不容忽视。最近研究表明，补充VD可有效改善危重症患者的预后，是辅助治疗危重症疾病颇具潜力的手段之一。本文现对VD在危重症疾病治疗中的相关文献进行总结，希望能对进一步提高危重症疾病预后提供帮助。

    【关键词】 危重症 维生素D 预后

    Mechanism and Research Progress of Vitamin D Adjuvant Therapy for Critical Illness/SONG Huijie， WANG Yu， WU Fangfang， DU Fanfan. //Medical Innovation of China， 2024， 21(19)： -184

    [Abstract] Critical illness is often accompanied by systemic inflammatory response syndrome. During this period， oxidative products such as reactive oxygen species and nitric oxide increase， while the concentration of protective antioxidants decreases. Imbalanced oxidative stress can lead to cell， tissue and organ damage and increase the mortality of critically ill patients. As an essential nutrient for human metabolism， vitamin D (VD) plays an important role in many physiological processes， and the role of VD in the adjuvant treatment of critically illness cannot be ignored. Recent studies have shown that VD supplementation can effectively improve the prognosis of critically ill patients and is one of the potential means for adjuvant treatment of critically illness. In this paper ......