曲美他嗪治疗老年冠心病78例疗效观察(1)
【摘要】 目的：探讨盐酸曲美他嗪治疗老年冠心病患者的疗效，并与单硝酸异山梨酯片的治疗效果进行对比，以期为临床治疗老年冠心病提供依据。方法：选取笔者所在医院2009年1月-2011年1月收治的符合慢性稳定型心绞痛诊断标准的90例患者，按照随机数字表法将其分为曲美他嗪组和硝酸异山梨酯片组各45例。在常规治疗的基础上，曲美他嗪组加用盐酸曲美他嗪片治疗，硝酸异山梨酯片组加用单硝酸异山梨酯片治疗，3个月为一疗程。治疗3个月后，分别统计两组患者的心绞痛发作时间、发作的频率及心电图改变资料，并对所得数据进行统计学分析，观察比较两组患者的临床疗效和心电图疗效。结果：经治疗后，曲美他嗪组的治疗总有效率82.22%明显高于硝酸异山梨酯片组的57.78%，心电图总有效率77.78%明显高于硝酸异山梨酯片组的51.11%，差异均有统计学意义(P<0.05)。两组治疗期间均未发生不良反应。结论：曲美他嗪是一种新型的治疗老年冠心病的药物，其治疗效果明显优于传统的治疗药物，是临床治疗老年冠心病用药的一个新选择，值得临床广泛推广。
【关键词】 曲美他嗪； 单硝酸异山梨酯片； 冠心病； 心绞痛
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中图分类号 R514.4 文献标识码 B 文章编号 1674-6805(2014)35-0029-03
【Abstract】 Objective：To investigate the clinical efficacy of Trimetazidine in the treatment of elderly patients with coronary heart disease，and compare with the clinical efficacy of Isosorbide Mononitrate Tablets，in order to provide basis for clinical treatment of senile coronary heart disease.Method：90 patients who consistent with the diagnosis of chronic stable angina standard admitted to our hospital from January 2009 to January 2011 were selected，they were divided into the Trimetazidine group and the Isosorbide Dinitrate Tablet group according to the random number table method，45 cases in each group.On the basis of conventional therapy，the Trimetazidine group was given Trimetazidine Dihydrochloride Tablets for treatment，the Isosorbide Dinitrate Tablet group was given Isosorbide Mononitrate Tablets for treatment，a treatment course was 3 month.After 3 months of treatment，the data of angina pectoris attack time，frequency and ECG changes in the two groups were statistically analyzed，the clinical effect and electrocardiogram efficacy between the two groups were observed and compared.Result：After treatment，the total effective rate of Trimetazidine group was 82.22%，it was significantly higher than 57.78% of Isosorbide Dinitrate Tablet group，and the total effective rate of electrocardiogram in Trimetazidine group was 77.78%，it was significantly higher than 51.11% of Isosorbide Dinitrate Tablet group，the differences were statistically significant(P<0.05).The two groups were no adverse reaction during the treatment period.Conclusion：Trimetazidine is a new type of treatment of senile coronary heart disease，its curative effect is obviously superior to the traditional drug treatment，is a new choice for clinical treatment of senile coronary heart disease medication，is worthy of clinical widely promotion.
【Key words】 Trimetazidine； Isosorbide Mononitrate Tablets； Coronary heart disease； Angina
冠心病的发病率正随着生活水平的提高及社会老龄化水平的加重而逐渐升高。冠心病主要病因是冠状动脉供血不足与需求指间不平衡，从而导致心肌缺血性损害的疾病[1]。它严重威胁着中老年患者的身体健康，而目前临床治疗老年冠心病主要是使用减轻心肌耗氧量的药物[2]。而本文通过对曲美他嗪和传统药物疗效的对比，突出曲美他嗪的疗效，为临床用药提供依据和借鉴，现具体报告如下。, 百拇医药(王海军 樊秀花)
【关键词】 曲美他嗪； 单硝酸异山梨酯片； 冠心病； 心绞痛
, http://www.100md.com
中图分类号 R514.4 文献标识码 B 文章编号 1674-6805(2014)35-0029-03
【Abstract】 Objective：To investigate the clinical efficacy of Trimetazidine in the treatment of elderly patients with coronary heart disease，and compare with the clinical efficacy of Isosorbide Mononitrate Tablets，in order to provide basis for clinical treatment of senile coronary heart disease.Method：90 patients who consistent with the diagnosis of chronic stable angina standard admitted to our hospital from January 2009 to January 2011 were selected，they were divided into the Trimetazidine group and the Isosorbide Dinitrate Tablet group according to the random number table method，45 cases in each group.On the basis of conventional therapy，the Trimetazidine group was given Trimetazidine Dihydrochloride Tablets for treatment，the Isosorbide Dinitrate Tablet group was given Isosorbide Mononitrate Tablets for treatment，a treatment course was 3 month.After 3 months of treatment，the data of angina pectoris attack time，frequency and ECG changes in the two groups were statistically analyzed，the clinical effect and electrocardiogram efficacy between the two groups were observed and compared.Result：After treatment，the total effective rate of Trimetazidine group was 82.22%，it was significantly higher than 57.78% of Isosorbide Dinitrate Tablet group，and the total effective rate of electrocardiogram in Trimetazidine group was 77.78%，it was significantly higher than 51.11% of Isosorbide Dinitrate Tablet group，the differences were statistically significant(P<0.05).The two groups were no adverse reaction during the treatment period.Conclusion：Trimetazidine is a new type of treatment of senile coronary heart disease，its curative effect is obviously superior to the traditional drug treatment，is a new choice for clinical treatment of senile coronary heart disease medication，is worthy of clinical widely promotion.
【Key words】 Trimetazidine； Isosorbide Mononitrate Tablets； Coronary heart disease； Angina
冠心病的发病率正随着生活水平的提高及社会老龄化水平的加重而逐渐升高。冠心病主要病因是冠状动脉供血不足与需求指间不平衡，从而导致心肌缺血性损害的疾病[1]。它严重威胁着中老年患者的身体健康，而目前临床治疗老年冠心病主要是使用减轻心肌耗氧量的药物[2]。而本文通过对曲美他嗪和传统药物疗效的对比，突出曲美他嗪的疗效，为临床用药提供依据和借鉴，现具体报告如下。, 百拇医药(王海军 樊秀花)