无创正压通气联合噻托溴铵对AECOPD合并呼吸衰竭患者预后的影响(1)
【摘要】 目的：探討无创正压通气联合噻托溴铵对慢性阻塞性肺病急性发作(AECOPD)合并呼吸衰竭患者预后的影响。方法：将80例AECOPD合并呼吸衰竭患者，随机分成对照组和观察组，各40例。对照组行呼吸内科常规治疗+无创正压通气治疗，观察组行呼吸内科常规治疗+无创正压通气治疗+噻托溴铵治疗。比较两组患者的有效率、插管率、病死率、住院时长、住院费用，以及治疗前和治疗72 h后呼吸困难量表评分(mMRC)和动脉血气分析指标。结果：观察组治疗有效率、插管率、病死率、住院时长、住院费用均明显优于对照组，差异有统计学意义(P<0.05)；观察组治疗72 h后mMRC评分和动脉血气分析指标：pH值、动脉血氧分压值(PaO2)及二氧化碳分压值(PaCO2)均优于对照组，差异有统计学意义(P<0.05)。结论：无创正压通气联合噻托溴铵可显著改善AECOPD合并呼吸衰竭患者血气分析指标，并减少插管率、病死率、住院时长及住院费用，改善预后。
【关键词】 慢性阻塞性肺病； 呼吸衰竭； 无创正压通气； 噻托溴铵
doi：10.14033/j.cnki.cfmr.2017.27.008 文献标识码 B 文章编号 1674-6805(2017)27-0016-03
Prognostic Value of Noninvasive Positive Pressure Ventilation Combined with Tiotropium Bromide in Patients with AECOPD Complicated with Respiratory Failure/SUN Cheng-ai，CHEN Kai-xiang， ZHOU Xin-hua.//Chinese and Foreign Medical Research，2017，15(27)：16-18
【Abstract】 Objective：To investigate the effect of noninvasive positive pressure ventilation combined with Tiotropium Bromide on the prognosis of patients with chronic obstructive pulmonary disease with acute exacerbation(AECOPD) complicated with respiratory failure.Method：80 cases of AECOPD patients with respiratory failure were randomly divided into control group and observation group，each of 40 cases.40 cases of the control group received routine respiratory therapy plus noninvasive positive pressure ventilation.Noninvasive positive pressure ventilation therapy plus Tiotropium Bromide was in the treatment of the observation group on the basis of routine therapy.The effective rate，intubation rate，fatality rate，length of stay，hospitalization expenses，and dyspnea score scale(mMRC) and arterial blood gas analysis index before and after treatment of 72 h were compared between the two groups.Result：The effective rate，intubation rate，mortality，length of stay，cost of hospitalization of the observation group were significantly better than the those of the control group(P<0.05)；the observation group after the treatment of 72 h mMRC score and arterial blood gas analysis index：pH，arterial oxygen partial pressure(PaO2) and carbon dioxide partial pressure(PaCO2) were also better than those of the control group(P<0.05).Conclusion：Noninvasive positive pressure ventilation combined with Tiotropium Bromide can significantly improve the blood gas analysis index of AECOPD patients with respiratory failure，and reduce the intubation rate，mortality，length of stay and hospitalization expenses，and improve prognosis.
【Key words】 Chronic obstructive pulmonary disease(COPD)； Respiratory failure； Noninvasive positive pressure ventilation； Tiotropium Bromide, 百拇医药(孙成爱 陈开祥 周新华)
【关键词】 慢性阻塞性肺病； 呼吸衰竭； 无创正压通气； 噻托溴铵
doi：10.14033/j.cnki.cfmr.2017.27.008 文献标识码 B 文章编号 1674-6805(2017)27-0016-03
Prognostic Value of Noninvasive Positive Pressure Ventilation Combined with Tiotropium Bromide in Patients with AECOPD Complicated with Respiratory Failure/SUN Cheng-ai，CHEN Kai-xiang， ZHOU Xin-hua.//Chinese and Foreign Medical Research，2017，15(27)：16-18
【Abstract】 Objective：To investigate the effect of noninvasive positive pressure ventilation combined with Tiotropium Bromide on the prognosis of patients with chronic obstructive pulmonary disease with acute exacerbation(AECOPD) complicated with respiratory failure.Method：80 cases of AECOPD patients with respiratory failure were randomly divided into control group and observation group，each of 40 cases.40 cases of the control group received routine respiratory therapy plus noninvasive positive pressure ventilation.Noninvasive positive pressure ventilation therapy plus Tiotropium Bromide was in the treatment of the observation group on the basis of routine therapy.The effective rate，intubation rate，fatality rate，length of stay，hospitalization expenses，and dyspnea score scale(mMRC) and arterial blood gas analysis index before and after treatment of 72 h were compared between the two groups.Result：The effective rate，intubation rate，mortality，length of stay，cost of hospitalization of the observation group were significantly better than the those of the control group(P<0.05)；the observation group after the treatment of 72 h mMRC score and arterial blood gas analysis index：pH，arterial oxygen partial pressure(PaO2) and carbon dioxide partial pressure(PaCO2) were also better than those of the control group(P<0.05).Conclusion：Noninvasive positive pressure ventilation combined with Tiotropium Bromide can significantly improve the blood gas analysis index of AECOPD patients with respiratory failure，and reduce the intubation rate，mortality，length of stay and hospitalization expenses，and improve prognosis.
【Key words】 Chronic obstructive pulmonary disease(COPD)； Respiratory failure； Noninvasive positive pressure ventilation； Tiotropium Bromide, 百拇医药(孙成爱 陈开祥 周新华)