姜黄素对大鼠脊髓损伤后神经元GAP—43表达变化的影响(2)
总之，姜黄素通过抑制神经胶质细胞活化、抗炎、抑制钙超载、抑制蛋白质聚积，改善脊髓内环境，有利于神经系统功能恢复。
参考文献
[1] Yang Y，Duan W，Liang Z，et al.Curcumin attenuates endothelia l cell oxidative stress injury through Notch signaling inhibition[J].Cell Signal，2013，25(3)：615-629.
[2] Duan W，Yang Y，Yan J，et al.The effects of curcumin post treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway[J].Archiv Für Kreislaufforschung，2012，107(3)：1-12.
[3] Yang Y，Duan W，Lin Y，et al.SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury[J].Free Radical Biol Med，2013，65(4)：667-679.
[4] Bharat B Aggarwal，Kuzhuvelil B，Harikumar1.Potential therapeutic effects of curcumin，the antiinflammatory agent，against neurodegenerative，cardiovascular，pulmonary，metabolic，autoimmune and neop lastic diseases[J].Int J Biochem Cell Biol，2009，41(1)：401.
[5]张月娥.硫辛酸对大鼠脊髓继发性损伤的保护作用及其机制的探讨[D].石家庄：河北医科大学，2011：14-26.
[6] Basso D M，Beattie M S，Bresnahan J C.A sensitive and reliable locomotor rating scale for open field testing in rats[J].J Neurotrauma，1995，12(1)：1-21.
[7] Tator C H.Biology of neurological recovery and functional restoration after spinal cord injury[J].Neurosurgery，1998，42(4)：696-707.
[8] Allegra Mascaro A L，Cesare P，Sacconi L，et al.In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex[J].Proc Natl Acad Sci USA，2013，110(26)：10824-10829.
[9] Latchney S E，Masiulis I，Zaccaria K J，et al.Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume[J].Dev Neurosci，2014，36(1)：44-63.
[10] Bird C W，Gardiner A S，Bolognani F，et al.KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons[J].PLoS One，2013，8(11)：e79255.
[11]鄒明明，薛兴森，朱海涛，等.姜黄素促进大鼠脊髓损伤恢复的病理及行为学研究[J].第三军医大学学报，2011，33(8)：765-770.
[12] Edware D，Hall J E.Neuro protection and acute spinal cord injury[J].A Reap praisal Neurorx，2004，1(1)：80-100.
(收稿日期：2017-08-03), 百拇医药(王笑音)
参考文献
[1] Yang Y，Duan W，Liang Z，et al.Curcumin attenuates endothelia l cell oxidative stress injury through Notch signaling inhibition[J].Cell Signal，2013，25(3)：615-629.
[2] Duan W，Yang Y，Yan J，et al.The effects of curcumin post treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway[J].Archiv Für Kreislaufforschung，2012，107(3)：1-12.
[3] Yang Y，Duan W，Lin Y，et al.SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury[J].Free Radical Biol Med，2013，65(4)：667-679.
[4] Bharat B Aggarwal，Kuzhuvelil B，Harikumar1.Potential therapeutic effects of curcumin，the antiinflammatory agent，against neurodegenerative，cardiovascular，pulmonary，metabolic，autoimmune and neop lastic diseases[J].Int J Biochem Cell Biol，2009，41(1)：401.
[5]张月娥.硫辛酸对大鼠脊髓继发性损伤的保护作用及其机制的探讨[D].石家庄：河北医科大学，2011：14-26.
[6] Basso D M，Beattie M S，Bresnahan J C.A sensitive and reliable locomotor rating scale for open field testing in rats[J].J Neurotrauma，1995，12(1)：1-21.
[7] Tator C H.Biology of neurological recovery and functional restoration after spinal cord injury[J].Neurosurgery，1998，42(4)：696-707.
[8] Allegra Mascaro A L，Cesare P，Sacconi L，et al.In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex[J].Proc Natl Acad Sci USA，2013，110(26)：10824-10829.
[9] Latchney S E，Masiulis I，Zaccaria K J，et al.Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume[J].Dev Neurosci，2014，36(1)：44-63.
[10] Bird C W，Gardiner A S，Bolognani F，et al.KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons[J].PLoS One，2013，8(11)：e79255.
[11]鄒明明，薛兴森，朱海涛，等.姜黄素促进大鼠脊髓损伤恢复的病理及行为学研究[J].第三军医大学学报，2011，33(8)：765-770.
[12] Edware D，Hall J E.Neuro protection and acute spinal cord injury[J].A Reap praisal Neurorx，2004，1(1)：80-100.
(收稿日期：2017-08-03), 百拇医药(王笑音)