摘 要目的：探讨早期应用高容量血液滤过(HVHF)对家猪多器官功能障碍综合征(MODS)急性心功能不全的防治效果。方法：19头雄性家猪随机分为实验组(M组，n=9)和治疗组(HF组，n=10)，两组均给予二次打击建立猪MODS模型；治疗组在复制模型后进行高容量血液滤过。以多道生物信号分析系统监测治疗前后心血管功能。结果：实验组动物死亡率为77.8%(7/9)， MODS发生率为88.9%(8/9)，治疗组动物死亡率为20%(2/10)。治疗组外周血管阻力指数、心博指数、左室每博功指数等指标均明显好转， 与实验组相比有显著性差异(P<0.05)。结论：早期应用高容量血液滤过能改善血流动力学指标，降低死亡率，对防治多器官功能障碍综合征急性心功能不全有较好的治疗效果。

    关键词高容量血液滤过；多器官功能障碍综合征；急性心功能不全；动物模型

    AbstractOBJECTIVE: To investigate the prevention and treatment of acute cardiac insufficiency in multiple organ dysfunction syndrome (MODS) with high volume hemofiltration (HVHF). METHODS: We duplicated the two-hit porcine model of MODS. Nighteen male pigs were randomly assigned into experimental group (group M, n=9) and therapeutic group(group HF,n=10) . The two groups were given two-hit factors to duplicate procine model of MODS. When the MODS model has been established, the group HF accepted the treatment of high volume hemofiltration. The Cardiovascular function was monitored by multichannel bio-signal detector. RESULTS: The mortality of group M was 77.8%(7/9) , and the incidence rate of MODS was 88.9%(8/9). The mortality of group HF was 20%(2/10), and the index of group HF were significantly better than that of the group M, such as systemic vascular resistance index, stroke index, left ventricle stroke work index,et al. CONCOLUTION: It was effective about the therapeutic results for acute cardiac insufficiency in MODS with HVHF. ......