血清肿瘤标志物在肺癌诊断中的应用(1)
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【摘要】 目的 探讨4 种血清肿瘤标志物在肺癌诊断中的应用价值。方法 应用电化学发光免疫测定(ECLI)220例肺癌患者、60例肺部良性疾病患者血清中癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE) 、细胞角蛋白19(Cyfra21-1) 和糖类抗原125(CA125)的水平含量。结果 肺癌患者的4种血清肿瘤标志物水平均明显高于肺部良性疾病组，差异有统计学意义( P < 0.01) 。NSE在小细胞肺癌中的水平明显高于其他类型的肺癌( P < 0.05) ，Cyfra21-1在鳞癌中的水平明显高于其他类型的肺癌( P < 0.05) 。NSE 对小细胞肺癌检测的敏感性明显高于其他肿瘤标志物( P < 0. 05)，CEA 对腺癌检测的敏感性明显高于其他肿瘤标志物( P < 0.05) 。结论 4种血清肿瘤标志物对于肺癌的诊断有一定的临床价值。NSE可作为检测小细胞肺癌的首选标志物，CEA对腺癌的辅助诊断有一定的作用，Cyfra21-1对鳞癌的辅助诊断有一定的作用。
【关键词】 肿瘤标志物；肺癌；癌胚抗原；神经元特异性烯醇化酶；细胞角蛋白19；糖类抗原125。
The value of serum tumor marker in the diagnosis of lung cancer
Lv-hongbo,xu-yi,pang-zuoliang
Department of Thoracic Surgery Affiliated Tumor Hospital,Xinjiang Medical University,Urumqi 830011,China
【Abstract】 Objective：Four kinds of serum tumor markers in lung cancer diagnosis application. Methods:Electrochemical luminescence immunoassay (ECLI) 220 patients with lung cancer, 60 cases of benign lung disease in patients with carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (Cyfra21-1) and carbohydrate antigen 125 (CA125) level of content. Results. patients with lung cancer the four serum tumor markers were significantly higher than those with benign lung disease group, the difference was statistically significant (P <0. 01). NSE in small cell lung cancer was significantly higher than other types of lung cancer (P <0. 05),Cyfra21-1 in squamous cell carcinoma was significantly higher than other types of lung cancer (P <0. 05). NSE in small cell lung cancer detection sensitivity was significantly higher than other tumor markers (P <0. 05), The sensitivity of CEA for adenocarcinoma was significantly higher than other tumor markers (P <0. 05). Conclusions:Four kinds of serum tumor markers for the diagnosis of lung cancer has clinical value. NSE can be used as the first choice for detection of small cell lung cancer marker, CEA diagnosis of adenocarcinoma have a certain effect. Cyfra21-1 diagnosis of squamous cell carcinoma have a certain effect.
【Key words】 Tumor marker; Lung cancer; Carcinoembryonic antigen Neuron-specific enolase;Cytokeratin 19; Carbohydrate antigen 125 ......
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