HPLC法测定注射用哌拉西林钠舒巴坦钠有关物质
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[摘要] 目的 建立注射用哌拉西林钠舒巴坦钠有关物质测定方法。氨苄西林回收率均值为(103.8±9.7)%；哌拉西林的定量限为4ng，检测限为1ng。样品溶液不稳定，需要配制后立即进样，耐用性试验显示需要选定专用色谱柱。 结论 本方法简便，专属性、重复性良好，可用于注射用哌拉西林钠舒巴坦钠有关物质的测定。
[关键词] 哌拉西林；舒巴坦；有关物质；高效液相色谱法
[中图分类号] R927.2 [文献标识码] B [文章编号] 2095-0616(2014)10-106-03
[Abstract] Objective To establish a method for the determination of related substances of piperacillin sodium and sulbactam sodium for injection. Methods The C18 column was used； The moving phase included water， acetonitrile and 0.2mol/L monopotassium solution， and the linear gradient elution was used； The detection wavelength was 220nm. Results The linear range was 1.5-36.3μg/mL for sulbactam， 1.7-40.6μg/mL for 1-ethyl-piperazine-2， 3-dione， 1.4-34.5μg/mL for ampicillin ......
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