[摘要] 目的 阿托伐他汀钙联合硝笨地平缓释片治疗轻中度高血压合并心脏病的临床疗效及其对肝肾功能的影响。 方法 随机将150例轻中度高血压合并左室肥厚患者分为两组，对照组给予硝苯地平缓释片治疗，治疗组在此基础上加用阿托伐他汀钙治疗。治疗18个月后，比较两组血压、左室后壁厚度(LVPW)和室间隔厚度(IVS)及肝肾功能。 结果 两组治疗后血压均达标，治疗组收缩压、舒张压下降较对照组明显。两组LVPW和IVS均有所改善，治疗组改善更加明显。治疗组有2例患者出现转氨酶升高而停用阿托伐他汀钙，对照组无1例发生肝肾功能损害。 结论 阿托伐他汀钙联合硝苯地平缓释片联合治疗轻中度高血压合并左室肥厚患者疗效更优，且无明显肝肾损害。

    [关键词] 轻中度高血压；左室肥厚；阿托伐他汀钙；硝笨地平缓释片

    [中图分类号] R544.1；R589.2 [文献标识码] B [文章编号] 2095-0616(2015)11-66-03

    [Abstract] Objective To ivvestigate the clinical effect of Atorvastatin calcium combined with Extended Release Nifedipine Tablets in the treatment of mild to moderate hypertension complicated with heart disease its effect on liver and renal function. Methods 150 patients with mild to moderate hypertension and left ventricular hypertrophy were divided into two groups ......