穴位注射联合中药颗料外洗治疗手部湿疹疗效观察(1)
[摘要] 目的 探讨观察穴位注射联合中药颗料外洗治疗手部湿疹的疗效。 方法 手部湿疹患者80例根据随机抽签方法分为治疗组与对照组各40例，对照组给予传统穴位注射治疗，治疗组在对照组治疗的基础上给予自拟中药颗粒洗剂治疗。 结果 治疗后治疗组的显效率分别为97.5%和85.0%，治疗组的显效率明显高于对照组(P<0.05)。两组治疗后的皮损与自觉症状评分明显低于治疗前(P<0.05)，同时治疗后治疗组的皮损与自觉症状评分明显低于对照组(P<0.05)。经过观察，两组治疗后血清IL-15和IL-21值明显低于治疗前(P<0.05)，同时治疗后治疗组的血清IL-15和IL-21值明显低于对照组(P<0.05)。 结论 穴位注射联合中药颗料外洗治疗手部湿疹能通过保护、润肤、收敛、抗过敏、止痒等综合作用改善临床症状，促进临床疗效的提高。
[关键词] 穴位注射；中药颗料外洗；手部湿疹；疗效
[中图分类号] R275 [文献标识码] B [文章编号] 2095-0616(2015)13-49-03
[Abstract] Objective To investigate the efficacy of point injection combined Chinese medicine granule washing treatment of hand eczema. Methods 80 patients with hand eczema accorded a random draw method were equally divided into the treatment group and control group， the control group were received traditional acupuncture point injection therapy， the treatment group were added given self-made medicine particles lotion treatment on the basis of the control group. Results The effective rates of the treatment group and the control group were 97.5% and 85.0% respectively which the treatment group had significantly higher efficiency (P<0.05). After treatment， the skin lesions and symptoms scores were significantly lower than before treatment (P<0.05)， while the lesions and symptoms scores in the treatment group were significantly lower than the control group (P<0.05). After treatment， the serum IL-15 and IL-21 were significantly lower than before treatment (P<0.05)， while serum IL-15 and IL-21 value of the treatment group were significantly lower than the control group (P<0.05). Conclusion Point injection combined Chinese medicine granule washing treatment of hand eczema can improve clinical symptoms by the protection， soothing， astringent， anti-allergy that promote the improvement of clinical efficacy.
[Key words] Point injection； Medicine granule washing； Hand eczema； Efficacy
手部湿疹是由于接触外界各种刺激物质引起的手部皮肤炎症反应，一般较难确定病因。多数起病缓慢，发病率高，临床表现为手部干燥，出现暗红斑，局部浸润肥厚，冬季常开裂[1-2]。多见于家庭主妇，因此也称为“主妇手”。 手部湿疹在临床上具有发病率高，病程长，易反复发作，严重影响患者的身心健康。目前西医对手部湿疹多采用皮质类固醇激素外用治疗，但是疗效不稳定，容易出现药物依赖性问题，长期应用还可能引起不良反应[3-4]。中医学认为手部湿疹为“湿疮”、“鹅掌风”等。其病因病机多由于风湿热邪客于肌肤，或多食肥甘、辛辣、酒类，致脾胃运化失常，生湿积热，外蕴肌肤而成，治以清热解毒、燥湿止痒为主[5]。合谷穴为阳明大肠经之原穴，均为皮肤瘙痒性疾病治疗之穴，通过对双侧合谷穴的注射可清热疏风，行气活血，以取“血行风自灭”之意，达到祛风、凉血和止痒之功效[6-7]。本研究具体观察了穴位注射联合中药颗料外洗治疗手部湿疹的疗效，现报道如下。
1 资料与方法
1.1 一般资料
收集2013年7月～2014年6月在我中心门诊就诊，符合手部湿疹诊断标准者80例作为研究对象，纳入标准：符合手部湿疹诊断标准；实验前两周内未接受对该病的药物治疗；皮损仅局限于手部而不累及身体其他部位；知情同意。排除标准：辨证不明确或有过多兼夹证；皮肤溃烂易感染者；合并心、脑、肝、肾和造血系统严重原发性疾病、精神病患者；妊娠或准备妊娠妇女，哺乳期妇女。其中男45例，女35例；年龄最小27岁，最大78岁，平均年龄(46.3±2.2)岁；病程最短4d，最长4个月，平均为(1.24±0.32)个月。根据随机抽签方法分为治疗组与对照组各40例，两组的病程、年龄与性别比较差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(陈树钊)
[关键词] 穴位注射；中药颗料外洗；手部湿疹；疗效
[中图分类号] R275 [文献标识码] B [文章编号] 2095-0616(2015)13-49-03
[Abstract] Objective To investigate the efficacy of point injection combined Chinese medicine granule washing treatment of hand eczema. Methods 80 patients with hand eczema accorded a random draw method were equally divided into the treatment group and control group， the control group were received traditional acupuncture point injection therapy， the treatment group were added given self-made medicine particles lotion treatment on the basis of the control group. Results The effective rates of the treatment group and the control group were 97.5% and 85.0% respectively which the treatment group had significantly higher efficiency (P<0.05). After treatment， the skin lesions and symptoms scores were significantly lower than before treatment (P<0.05)， while the lesions and symptoms scores in the treatment group were significantly lower than the control group (P<0.05). After treatment， the serum IL-15 and IL-21 were significantly lower than before treatment (P<0.05)， while serum IL-15 and IL-21 value of the treatment group were significantly lower than the control group (P<0.05). Conclusion Point injection combined Chinese medicine granule washing treatment of hand eczema can improve clinical symptoms by the protection， soothing， astringent， anti-allergy that promote the improvement of clinical efficacy.
[Key words] Point injection； Medicine granule washing； Hand eczema； Efficacy
手部湿疹是由于接触外界各种刺激物质引起的手部皮肤炎症反应，一般较难确定病因。多数起病缓慢，发病率高，临床表现为手部干燥，出现暗红斑，局部浸润肥厚，冬季常开裂[1-2]。多见于家庭主妇，因此也称为“主妇手”。 手部湿疹在临床上具有发病率高，病程长，易反复发作，严重影响患者的身心健康。目前西医对手部湿疹多采用皮质类固醇激素外用治疗，但是疗效不稳定，容易出现药物依赖性问题，长期应用还可能引起不良反应[3-4]。中医学认为手部湿疹为“湿疮”、“鹅掌风”等。其病因病机多由于风湿热邪客于肌肤，或多食肥甘、辛辣、酒类，致脾胃运化失常，生湿积热，外蕴肌肤而成，治以清热解毒、燥湿止痒为主[5]。合谷穴为阳明大肠经之原穴，均为皮肤瘙痒性疾病治疗之穴，通过对双侧合谷穴的注射可清热疏风，行气活血，以取“血行风自灭”之意，达到祛风、凉血和止痒之功效[6-7]。本研究具体观察了穴位注射联合中药颗料外洗治疗手部湿疹的疗效，现报道如下。
1 资料与方法
1.1 一般资料
收集2013年7月～2014年6月在我中心门诊就诊，符合手部湿疹诊断标准者80例作为研究对象，纳入标准：符合手部湿疹诊断标准；实验前两周内未接受对该病的药物治疗；皮损仅局限于手部而不累及身体其他部位；知情同意。排除标准：辨证不明确或有过多兼夹证；皮肤溃烂易感染者；合并心、脑、肝、肾和造血系统严重原发性疾病、精神病患者；妊娠或准备妊娠妇女，哺乳期妇女。其中男45例，女35例；年龄最小27岁，最大78岁，平均年龄(46.3±2.2)岁；病程最短4d，最长4个月，平均为(1.24±0.32)个月。根据随机抽签方法分为治疗组与对照组各40例，两组的病程、年龄与性别比较差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(陈树钊)