阿奇霉素给药途径对小儿肺炎患者用药依从性及用药疗效的影响(1)
[摘要] 目的 探讨阿奇霉素给药途径对小儿肺炎患儿用药依从性及效果的影响。 方法 2014年2月～2016年2月我院接收的小儿肺炎患儿84例，根据阿奇霉素用药途径随机分为口服组、静脉组，各42例，对比两组患儿疗效、症状改善时间、治疗依从性及不良用药反应。 结果 两组患儿临床疗效、症状消失时间及住院时间差异无统计学意义(P>0.05)；口服组治疗依从性为85.71%显著高于静脉组59.52%，不良用药反应为7.14%显著低于静脉组23.81%，差异有统计学意义(P<0.05)。 结论 口服阿奇霉素疗效与静脉给药大致相同，但与后者相比，前者具有不良反应少、用药便利的优势，能提高患儿治疗依从性。
[关键词] 小儿肺炎；阿奇霉素；用药途径；依从性
[中图分类号] R725.6 [文献标识码] A [文章编号] 2095-0616(2017)09-62-03
Effect of administration route of azithromycin on medication compliance and curative effect in children with pneumonia
LIU Xiaoyan1 QIU Liuping2 WANG Li2 LING Yi1
1.Department of Pharmacy，Liuzhou Municipal Liutie Central Hospital，Liuzhou 545007，China；2.Department of Pediatrics，Liuzhou Municipal Liutie Central Hospital，Liuzhou 545007，China
[Abstract] Objective To explore the effect of administration route of azithromycin on medication compliance and curative effect in children with pneumonia. Methods 84 children with pneumonia who were admitted to the hospital from February 2014 to February 2016 were included in the study.According to the administration routes of azithromycin，they were divided into the oral group and the intravenous group，with 42 in each.Curative effects，time for symptoms improvement，treatment compliance and adverse drug reactions between the two groups were compared. Results Clinical curative effect，disappearing time for symptoms and hospitalization stay between 2 groups has no difference(P>0.05).Treatment compliance of the oral group was 85.71%，significantly higher than that of intravenous group 59.52%.While the rate of adverse drug reaction of the oral group was 7.14%，significantly lower than that of intravenous group 23.81%(P<0.05). Conclusion The curative effects of oral azithromycin and intravenous administration are similar.But compared with the latter，the former has fewer adverse reactions and convenient medication，which can improve treatment compliance of children.
[Key words] Children with pneumonia in；Azithromycin；Administration route；Compliance
小兒肺炎是儿科常见疾病，主要由细菌或病毒感染引起，临床常表现为发热、咳嗽、喘息、呼吸困难等，是住院小儿死亡的重要原因之一[1]。阿奇霉素属于新一代大环内酯类抗生素，具有抗菌谱广、半衰周期长，是临床治疗小儿肺炎的常见药物[2-3]。受医生、患儿家长对滥用注射剂危害认识不足的影响，习惯性将静脉滴注作为抗生素首选给药方式，会增加不良用药反应的发生率[4]。对此，本研究分析了阿奇霉素口服和静脉给药治疗小儿肺炎对临床疗效、用药安全性及患儿依从性等的影响，为临床合理用药方案提供资料，现报道如下。
1 资料与方法
1.1 一般资料
选取我院2014年2月～2016年2月收治的小儿肺炎患儿84例，均符合《诸福棠实用儿科学(第7版)》[5]中拟定的小儿肺炎诊断标准，根据阿奇霉素用药途径随机分为口服组、静脉组，各42例，所有患者均自愿参与作为研究对象。口服组中，男27例，女15例，年龄为7个月～5岁，平均(2.1±0.8)岁；其中33例发热，38例咳嗽，33例肺部湿性啰音。静脉组，男28例，女14例，年龄为10个月～4岁，平均(2.0±0.8)岁；其中36例发热，38例咳嗽，35例肺部湿性啰音。两组患儿性别、年龄、临床症状等一般资料比较差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(刘晓雁?邱柳萍?王励?凌义)
[关键词] 小儿肺炎；阿奇霉素；用药途径；依从性
[中图分类号] R725.6 [文献标识码] A [文章编号] 2095-0616(2017)09-62-03
Effect of administration route of azithromycin on medication compliance and curative effect in children with pneumonia
LIU Xiaoyan1 QIU Liuping2 WANG Li2 LING Yi1
1.Department of Pharmacy，Liuzhou Municipal Liutie Central Hospital，Liuzhou 545007，China；2.Department of Pediatrics，Liuzhou Municipal Liutie Central Hospital，Liuzhou 545007，China
[Abstract] Objective To explore the effect of administration route of azithromycin on medication compliance and curative effect in children with pneumonia. Methods 84 children with pneumonia who were admitted to the hospital from February 2014 to February 2016 were included in the study.According to the administration routes of azithromycin，they were divided into the oral group and the intravenous group，with 42 in each.Curative effects，time for symptoms improvement，treatment compliance and adverse drug reactions between the two groups were compared. Results Clinical curative effect，disappearing time for symptoms and hospitalization stay between 2 groups has no difference(P>0.05).Treatment compliance of the oral group was 85.71%，significantly higher than that of intravenous group 59.52%.While the rate of adverse drug reaction of the oral group was 7.14%，significantly lower than that of intravenous group 23.81%(P<0.05). Conclusion The curative effects of oral azithromycin and intravenous administration are similar.But compared with the latter，the former has fewer adverse reactions and convenient medication，which can improve treatment compliance of children.
[Key words] Children with pneumonia in；Azithromycin；Administration route；Compliance
小兒肺炎是儿科常见疾病，主要由细菌或病毒感染引起，临床常表现为发热、咳嗽、喘息、呼吸困难等，是住院小儿死亡的重要原因之一[1]。阿奇霉素属于新一代大环内酯类抗生素，具有抗菌谱广、半衰周期长，是临床治疗小儿肺炎的常见药物[2-3]。受医生、患儿家长对滥用注射剂危害认识不足的影响，习惯性将静脉滴注作为抗生素首选给药方式，会增加不良用药反应的发生率[4]。对此，本研究分析了阿奇霉素口服和静脉给药治疗小儿肺炎对临床疗效、用药安全性及患儿依从性等的影响，为临床合理用药方案提供资料，现报道如下。
1 资料与方法
1.1 一般资料
选取我院2014年2月～2016年2月收治的小儿肺炎患儿84例，均符合《诸福棠实用儿科学(第7版)》[5]中拟定的小儿肺炎诊断标准，根据阿奇霉素用药途径随机分为口服组、静脉组，各42例，所有患者均自愿参与作为研究对象。口服组中，男27例，女15例，年龄为7个月～5岁，平均(2.1±0.8)岁；其中33例发热，38例咳嗽，33例肺部湿性啰音。静脉组，男28例，女14例，年龄为10个月～4岁，平均(2.0±0.8)岁；其中36例发热，38例咳嗽，35例肺部湿性啰音。两组患儿性别、年龄、临床症状等一般资料比较差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(刘晓雁?邱柳萍?王励?凌义)