注射用糜蛋白酶预防鼻肠管堵塞作用的临床研究(1)
[摘要] 目的 分析注射用糜蛋白酶在预防鼻肠管堵塞中的临床作用。 方法 随机选取2015年3月～2016年8月80例普外科腹部手术后留置鼻肠管进行肠内营养的患者作为研究对象，分为治疗组与对照组，每组40例。治疗组采用滴注完营养液后用温热注射用水50mL冲管后，再用注射用糜蛋白酶4000单位加0.9%生理盐水50mL封管，隔日1次；对照组采用营养液滴注完后用温热注射用水50mL冲管。观察两组患者堵管发生率、住院时间、营养不良发生率和血清白蛋白指标的差异。 结果 治疗组与对照组的堵管发生率分别为7.5%和20.0%、住院时间分别为(12.6±4.2)d和(16.4±7.6)d，观察组在各方面显著优于对照组，两组间的比较差异具有统计学意义(P<0.05)。 结论 注射用糜蛋白酶能够有效预防鼻肠管堵塞，避免鼻肠管堵塞引起的不良反应，改善患者的预后情况，提高患者的生活质量。
[关键词] 注射用糜蛋白酶；鼻肠管堵塞；预后情况；肠内营养
[中图分类号] R472 [文献标识码] A [文章编号] 2095-0616(2017)20-155-03
Clinical study of Chymotrypsin for Injection in preventing obstruction of nasal intestinal tube
LI Na LIANG Yi FANG Yanxia LUO Hongzhi CHEN Hong
The People's Hospital of Zhongshan City，Zhongshan 528403，China
[Abstract] Objective To analyze the clinical effect of Chymotrypsin for Injection in preventing obstruction of nasal tube. Methods 80 cases of patients undergoing enteral nutrition with indwelling nasal tube after abdominal surgery from March 2015 to August 2016 were randomly selected.The patients were divided into treatment group and control group，40 cases in each group.The patients of treatment group were treated with drip injection of nutrient solution，with warm water injection 50mL，flushed tube， and then with Chymotrypsin for Injection 4000 units plus 0.9% physiological saline 50ml sealed tube，1 times every other day.The patients of control group were treated with drip injection of nutrient solution，after injection，with warm water injection 50mL，flushed tube.The incidence of blocked tube，hospitalization time，incidence of malnutrition and serum albumin index were observed between the two groups. Results In treatment group and control group，the plugging rate of were 7.5% and 20%，the hospitalization were(12.6±4.2)d and (16.4±7.6)d，all indexes of observation group were significantly better than those of control group，the differences were statistically significant between the two groups(P<0.05). Conclusion Chymotrypsin for Injection can effectively prevent the obstruction of the nasal duct and avoid the adverse reactions caused by the obstruction of the nasal duct，improve the prognosis of the patients and improve the quality of life of the patients.
[Key words] Chymotrypsin for Injection； Obstruction of nasal intestinal tube； Prognosis； Enteral nutrition
近年來肠内营养在胃肠道手术后、胰腺炎、及危重患者中的应用越来越广泛。而鼻肠管由于置管简单、创伤小的优点，越来越受到外科医生的欢迎[1]。但是因鼻肠管管径细、管道长的特点，其最常见的机械性并发症是管道堵塞，而一旦导管堵塞，将耗费护理人员大量的时间和精力将导管疏通，有部分患者被迫拔管，改用肠外营养[2]。本研究选择普外科腹部手术后留置鼻肠管进行肠内营养的患者作为研究对象，比较评估两种不同冲管方法对管道堵塞的预防效果。期望通过此项技术的开展，降, 百拇医药(李娜 梁义 方艳霞 雒洪志 陈宏)
[关键词] 注射用糜蛋白酶；鼻肠管堵塞；预后情况；肠内营养
[中图分类号] R472 [文献标识码] A [文章编号] 2095-0616(2017)20-155-03
Clinical study of Chymotrypsin for Injection in preventing obstruction of nasal intestinal tube
LI Na LIANG Yi FANG Yanxia LUO Hongzhi CHEN Hong
The People's Hospital of Zhongshan City，Zhongshan 528403，China
[Abstract] Objective To analyze the clinical effect of Chymotrypsin for Injection in preventing obstruction of nasal tube. Methods 80 cases of patients undergoing enteral nutrition with indwelling nasal tube after abdominal surgery from March 2015 to August 2016 were randomly selected.The patients were divided into treatment group and control group，40 cases in each group.The patients of treatment group were treated with drip injection of nutrient solution，with warm water injection 50mL，flushed tube， and then with Chymotrypsin for Injection 4000 units plus 0.9% physiological saline 50ml sealed tube，1 times every other day.The patients of control group were treated with drip injection of nutrient solution，after injection，with warm water injection 50mL，flushed tube.The incidence of blocked tube，hospitalization time，incidence of malnutrition and serum albumin index were observed between the two groups. Results In treatment group and control group，the plugging rate of were 7.5% and 20%，the hospitalization were(12.6±4.2)d and (16.4±7.6)d，all indexes of observation group were significantly better than those of control group，the differences were statistically significant between the two groups(P<0.05). Conclusion Chymotrypsin for Injection can effectively prevent the obstruction of the nasal duct and avoid the adverse reactions caused by the obstruction of the nasal duct，improve the prognosis of the patients and improve the quality of life of the patients.
[Key words] Chymotrypsin for Injection； Obstruction of nasal intestinal tube； Prognosis； Enteral nutrition
近年來肠内营养在胃肠道手术后、胰腺炎、及危重患者中的应用越来越广泛。而鼻肠管由于置管简单、创伤小的优点，越来越受到外科医生的欢迎[1]。但是因鼻肠管管径细、管道长的特点，其最常见的机械性并发症是管道堵塞，而一旦导管堵塞，将耗费护理人员大量的时间和精力将导管疏通，有部分患者被迫拔管，改用肠外营养[2]。本研究选择普外科腹部手术后留置鼻肠管进行肠内营养的患者作为研究对象，比较评估两种不同冲管方法对管道堵塞的预防效果。期望通过此项技术的开展，降, 百拇医药(李娜 梁义 方艳霞 雒洪志 陈宏)