摘要 目的：观察辛伐他汀治疗脂肪肝对患者肝功能及睡眠质量的影响。方法：选取2016年4月至2018年4月福建医科大学孟超肝胆医院肝内科收治的非酒精性脂肪肝患者60例作为研究对象，随機分为观察组和对照组，每组30例。对照组低脂饮食，适当运动，观察组在对照组的基础上服用辛伐他汀治疗。比较2组患者血脂变化、肝功能变化、睡眠质量变化。结果：2组患者治疗初始血脂各项指标之间无统计学意义(P>0.05)，治疗后观察组患者的TC、LDL-C、TG均显著低于对照组，HDL-C高于对照组(P0.05)，治疗后观察组患者的ALT、AST、γ-GGT、TBiL均显著低于对照组(P0.05)。结论：辛伐他汀能够有效调节血脂，改善脂肪肝患者肝功能的同时不影响患者睡眠质量。

    关键词 辛伐他汀；脂肪肝；肝功能；睡眠质量

    Abstract Objective：To observe the effect of simvastatin on liver function and sleep quality in patients with fatty liver.Methods：A Total of 60 patients with non-alcoholic fatty liver admitted to the Department of Hepatology of our hospital from April 2016 to April 2018were studied as the research objects.They were randomly divided into simvastatin group and control group with 30 patients in each group.The control group was fed a low-fat diet and exercised properly.The simvastatin group was treated with simvastatin on the basis of the control group.The changes of blood lipid ......