【摘 要】目的：探讨顺尔宁联合双水平气道正压通气(BiPAP)呼吸机治疗重症肺炎合并呼吸衰竭的临床疗效。方法：选取160例重症肺炎合并呼吸衰竭患者为研究对象，按照随机数字表法分为2组，顺尔宁联合BiPAP呼吸机治疗组(联合组)80例，单用BiPAP呼吸机组(呼吸机组)80例；比较2组患者入院时及治疗后临床症状，血清炎症因子、好转率等方面差异。结果：两组治疗前后，TNF-α、IL-6、CRP值差异有统计学意义(P<0.05)，且联合组TNF-α、IL-6、CRP值明显低于呼吸机组(P<0.05)。联合组好转率显著优于呼吸机组(95.00%/75.00%)，差异有统计学意义(P<0.05)。结论：顺尔宁联合双水平气道正压通气(BiPAP)呼吸机治疗重症肺炎合并呼吸衰竭有较好的临床疗效。

    【关键词】顺尔宁；双水平气道正压通气；重症肺炎；呼吸衰竭

    [Abstract]Objective： To evaluate the clinical efficacy of montelukast sodium tablets combined with BiPAP respirator in treatment of severe pneumonia with acute respiratory failure. Methods： A total of 160patients with severe pneumonia with acute respiratory failure were chosen and were divided into the two group according to the Random number table.montelukast sodium tablets combined with BiPAP respirator group(joint group) ......