[摘要]目的探讨磁共振(MRI)扩散峰度成像(DKI)在乳腺良恶性病变鉴别诊断中的应用价值。方法选取我院普外科诊治的乳腺病变病人110例，经穿刺活检或手术病理证实。110例病人共137个病灶，良性病灶53个(40例)，恶性病灶84个(70例)。病人进行乳腺常规MRI和DKI检查，记录病灶的平均峰度系数(MK)、横向峰度系数(AK)、径向峰度系数(RK)、平均扩散系数(MD)、径向扩散系数(RD)、各向异性系数(FA)，采用受试者工作特征(ROC)曲线评价上述指标对乳腺良恶性疾病鉴别诊断的效能。结果恶性病灶MK、AK、RK、FA均显著高于良性病灶，MD值显著低于良性病灶(t=3.35～15.51，Plt;0.05)。以穿刺活检或术后病理为金标准，对DKI检查参数MK、AK、RK、MD、RD、FA值做鉴别乳腺良恶性疾病的ROC曲线分析，MK、AK、MD的ROC曲线下面积gt;0.8，灵敏度和特异度均gt;85%。结论DKI指标MK、AK、MD对乳腺良恶性病变的鉴别诊断有一定指导意义。

    [关键词]乳腺肿瘤;磁共振成像;诊断，鉴别

    [中图分类号]R445.2[文献标志码]A[文章编号] 2096-5532(2018)06-0652-04

    VALUE OF MAGNETIC RESONANCE DIFFUSION KURTOSIS IMAGING IN DIFFERENTIAL DIAGNOSIS OF BENIGN AND MALIGNANT BREAST LESIONS ZHENG Hua， FU Kong ""(Department of Radiology， The Second Affiliated Hospital of Hainan Medical University， "Haikou， 570311， China)

    [ABSTRACT]ObjectiveTo explore the value of magnetic resonance diffusion kurtosis imaging (DKI) in differential diagnosis of benign and malignant breast lesions. MethodsA total of 110 patients with breast diseases confirmed by aspiration biopsy or surgical"pathology were selected from the Department of General Surgery in our hospital. The 110 patients had 137 lesions ......