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    (Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi Guizhou 563099,China)

    基础医学研究

    OatpandMrpmRNAexpressionoflivertransportersinspontaneouslyhypertensiverats

    YueYun,WuYuting,FuShu,QianZhiqiang,LiYeli,YangDanli

    (Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi Guizhou 563099,China)

    ObjectiveTo investigate the effects of spontaneous hypertension on the mRNA expression of organic anion transporting polypeptides (Oatps) and multidrug resistance-associated proteins (Mrps) of hepatic tissue in spontaneously hypertensive rats (SHR).MethodsFourteen weeks old male SHR were the SHR group (SHR,n=10).The same aged male homologous Kyoto rats (WKY) were the WKY group (WKY,n=10).Rats were routine fed for 12 weeks.The mRNA expression of the major uptake transporter Oatp1a1,Oatp1a4,Oatp1a5 and Oatp1b2 as well as the main efflux transporters Mrp1,Mrp2,Mrp3 and Mrp4 were detected by Real time RT-PCR.The weight change of rats in each group were recorded every two weeks.Blood pressure change was detected in rats with Scientific CODA Kent system.ResultsCompared with the WKY group ......